Bcl-2 Family - Apoptosis

Cat.No. Product Name Information

BCC4098 Marinopyrrole A Maritoclax (Marinopyrrole A) is a novel and specific Mcl-1 inhibitor with an IC50 value of 10.1 μM, and shows >8 fold selectivity than BCL-xl (IC50 > 80 μM).

BCC2236 Sabutoclax Sabutoclax is a potent and effective Bcl-2 Family (Bcl-2, Bcl-XL, Mcl-1, Bfl-1) inhibitor with IC50s of 0.32 μM, 0.31 μM, 0.20 μM, and 0.62 μM, respectively.

BCC3614 ABT-199 Venetoclax (ABT-199; GDC-0199) is a highly potent, selective and orally bioavailable Bcl-2 inhibitor with a Ki of less than 0.01 nM. Venetoclax induces autophagy. ABT-199

BCC2395 Bax inhibitor peptide, negative control Negative control peptide for Bax inhibitor peptide V5

BCC2235 BM-1074 BM-1074

BCC6508 A-1210477 A-1210477 is a potent and selective inhibitor of MCL-1 with a Ki of 0.45 nM.

BCC2392 Bax channel blocker BAI1 is a direct allosteric inhibitor of BAX.

BCC2396 iMAC2 iMAC2

BCC2397 Muristerone A Stimulates Bcl-XL mRNA transcription; antiapoptotic

BCC5567 UMI-77 UMI-77 is a selective Mcl-1 inhibitor, which shows high binding affinity to Mcl-1 (IC50=0.31 μM). UMI-77 binds to the BH3 binding groove of Mcl-1 with Ki of 490 nM, showing selectivity over other members of anti-apoptotic Bcl-2 members. UMI-77

BCC2394 Bax inhibitor peptide V5 Bax inhibitor peptide V5 (BIP-V5) is a Bax-mediated apoptosis inhibitor, used for cancer treatment.

BCC2393 Bax inhibitor peptide P5

BCC3593 HA14-1 HA14-1 is a Bcl-2/Bcl-XL antagonist. HA14-1 binds the designated pocket on Bcl-2 with the IC50 of ≈9 μM in competing with the Bcl-2 binding of Flu-BakBH3, and inhibits its function. HA14-1

BCC5585 (+)-Apogossypol (+)-Apogossypol is a pan-BCL-2 antagonist. (+)-Apogossypol binds to Mcl-1, Bcl-2 and Bcl-xL with EC50s of 2.6, 2.8 and 3.69 µM, respectively.

BCC5405 Mcl1-IN-1 Mcl1-IN-1 is an inhibitor of myeloid cell factor 1 (Mcl-1) (IC50=2.4 µM).

BCC2234 Obatoclax mesylate (GX15-070) Obatoclax Mesylate (GX15-070 Mesylate), a BH3 mimetic, is a pan-BCL-2 family proteins inhibitor with a Ki of 220 nM for BCL-2. Obatoclax Mesylate induces autophagy-dependent cell death and targets cyclin D1 for proteasomal degradation. Obatoclax Mesylate has anti-cancer and broad-spectrum antiparasitic activity. Obatoclax mesylate (GX15-070)

BCC3613 ABT-737 ABT-737 is a selective and BH3 mimetic Bcl-2, Bcl-xL and Bcl-w inhibitor with EC50s of 30.3 nM, 78.7 nM, and 197.8 nM, respectively. ABT-737

BCC2257 TW-37 TW-37 is a potent Bcl-2 inhibitor with Ki values of 260, 290 and 1110 nM for Mcl-1, Bcl-2 and Bcl-xL, respectively. TW-37

BCC2237 Apogossypolone (ApoG2)

BCC1375 Gossypolone Downregulates Bcl-2 and Mcl-1; pro-apoptotic

BCC1272 ABT-263 (Navitoclax) Navitoclax (ABT-263) is a potent and orally active Bcl-2 family protein inhibitor that binds to multiple anti-apoptotic Bcl-2 family proteins, such as Bcl-xL, Bcl-2 and Bcl-w, with a Ki of less than 1 nM.

BCC6398 Radotinib(IY-5511)

Products for Bcl-2 Family