Bcl-2 Family
Bcl-2 family proteins are a group of proteins homologous to the Bcl-2 protein and characterized by containing at least one of four conserved Bcl-2 homology (BH) domains (BH1, BH2, BH3 and BH4). Bcl-2 family proteins, consisting of pro-apoptotic and anti-apoptotic molecules, can be classified into the following three subfamilies according to sequence homology within four BH domains: (1) a subfamily shares sequence homology within all four BH domains, such as Bcl-2, Bcl-XL and Bcl-w which are anti-apoptotic; (2) a subfamily shares sequence homology within BH1, BH2 and BH4, such as Bax and Bak which are pro-apoptotic; (3) a subfamily shares sequence homology only within BH3, such as Bik and Bid which are pro-apoptotic.
Products for Bcl-2 Family
- Cat.No. Product Name Information
- BCC1272 ABT-263 (Navitoclax)Potent Bcl-2 family inhibitor, inhibits Bcl-2, Bcl-xL, and Bcl-w
- BCC1375 AT-101Downregulates Bcl-2 and Mcl-1; pro-apoptotic
- BCC2234 Obatoclax mesylate (GX15-070)Potent Bcl-2 inhibitor
- BCC2235 BM-1074Bcl-2/Bcl-xL inhibitor,potent and selective
- BCC2236 Sabutoclaxpan-Bcl-2 inhibitor
- BCC2237 Apogossypolone (ApoG2)Bcl-2 inhibitor,nonpeptidic small molecule
- BCC2257 TW-37Bcl-2 inhibitor; induces apoptosis
- BCC2392 Bax channel blockerInhibitor of Bax-mediated mitochondrial cytochrome c release
- BCC2393 Bax inhibitor peptide P5Bax inhibitor
- BCC2394 Bax inhibitor peptide V5Inhibitor of Bax-mediated apoptosis
- BCC2395 Bax inhibitor peptide, negative controlNegative control peptide for Bax inhibitor peptide V5
- BCC2396 iMAC2MAC inhibitor
- BCC2397 Muristerone AStimulates Bcl-XL mRNA transcription; antiapoptotic
- BCC3593 HA14-1Bcl-2 inhibitor. Induces apoptosis
- BCC3613 ABT-737Bcl-2 inhibitor
- BCC3614 ABT-199Bcl-2 inhibitor,potent and selective
- BCC4098 Marinopyrrole AMcl-1 inhibitor; proapoptotic
- BCC5405 Mcl1-IN-1Myeloid cell factor 1 inhibitor
- BCC5567 UMI-77Mcl-1 inhibitor, novel
- BCC5585 (+)-Apogossypol
- BCC6398 Radotinib(IY-5511)Bcl-Abl tyrosine kinase inhibitor
- BCC6508 A-1210477MCL-1 inhibitor