iMAC2MAC inhibitor CAS# 335166-36-4 |
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Quality Control & MSDS
3D structure
Package In Stock
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| Cas No. | 335166-36-4 | SDF | Download SDF |
| PubChem ID | 9869276 | Appearance | Powder |
| Formula | C19H20Br2FN3 | M.Wt | 469.2 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | Limited solubility | ||
| Chemical Name | 3,6-dibromo-9-(2-fluoro-3-piperazin-1-ylpropyl)carbazole | ||
| SMILES | C1CN(CCN1)CC(CN2C3=C(C=C(C=C3)Br)C4=C2C=CC(=C4)Br)F | ||
| Standard InChIKey | BSTYITXHUQTYBA-UHFFFAOYSA-N | ||
| Standard InChI | InChI=1S/C19H20Br2FN3/c20-13-1-3-18-16(9-13)17-10-14(21)2-4-19(17)25(18)12-15(22)11-24-7-5-23-6-8-24/h1-4,9-10,15,23H,5-8,11-12H2 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
iMAC2 Dilution Calculator
iMAC2 Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.1313 mL | 10.6564 mL | 21.3129 mL | 42.6257 mL | 53.2822 mL |
| 5 mM | 0.4263 mL | 2.1313 mL | 4.2626 mL | 8.5251 mL | 10.6564 mL |
| 10 mM | 0.2131 mL | 1.0656 mL | 2.1313 mL | 4.2626 mL | 5.3282 mL |
| 50 mM | 0.0426 mL | 0.2131 mL | 0.4263 mL | 0.8525 mL | 1.0656 mL |
| 100 mM | 0.0213 mL | 0.1066 mL | 0.2131 mL | 0.4263 mL | 0.5328 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Inhibitor of mitochondrial apoptosis-induced channel (MAC) (IC50 = 28 nM). Reduces STS-induced apoptosis in FL5.12 cells by over 50%. Inhibits release of cytochrome c by Bid-induced Bax activation (IC50 = 0.68 μM).
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Implantable cardiac defibrillators and sudden death in recent onset nonischemic cardiomyopathy: results from IMAC2.[Pubmed:22939035]
J Card Fail. 2012 Sep;18(9):675-81.
BACKGROUND: Given the potential for recovery in recent onset nonischemic cardiomyopathy (ROCM), the timing and need for implantable cardioverter-defibrillator (ICDs) remains controversial. We examined the utilization of ICDs and the impact on survival for subjects with ROCM. METHODS AND RESULTS: An National Heart, Lung, and Blood Institute sponsored registry enrolled 373 subjects with ROCM, all with a left ventricular ejection fraction (LVEF)
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