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Miconazole nitrate

CAS# 22832-87-7

Miconazole nitrate

Catalog No. BCC9047----Order now to get a substantial discount!

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Quality Control of Miconazole nitrate

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Chemical structure

Miconazole nitrate

3D structure

Chemical Properties of Miconazole nitrate

Cas No. 22832-87-7 SDF Download SDF
PubChem ID 68553 Appearance Powder
Formula C18H15Cl4N3O4 M.Wt 479
Type of Compound N/A Storage Desiccate at -20°C
Synonyms R18134 nitrate
Solubility DMSO : 50 mg/mL (104.35 mM; Need ultrasonic)
H2O : < 0.1 mg/mL (insoluble)
Chemical Name 1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]imidazole;nitric acid
SMILES C1=CC(=C(C=C1Cl)Cl)COC(CN2C=CN=C2)C3=C(C=C(C=C3)Cl)Cl.[N+](=O)(O)[O-]
Standard InChIKey MCCACAIVAXEFAL-UHFFFAOYSA-N
Standard InChI InChI=1S/C18H14Cl4N2O.HNO3/c19-13-2-1-12(16(21)7-13)10-25-18(9-24-6-5-23-11-24)15-4-3-14(20)8-17(15)22;2-1(3)4/h1-8,11,18H,9-10H2;(H,2,3,4)
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Biological Activity of Miconazole nitrate

DescriptionAntifungal agent. Inhibits lanosterol demethylase and induces formation of reactive oxygen species. Enhances the generation of mature oligodendrocytes from progenitor cells in vitro and promotes myelination in vivo. Attenuates disease severity in a mouse model of multiple sclerosis. Brain penetrant.

Miconazole nitrate Dilution Calculator

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Miconazole nitrate Molarity Calculator

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Preparing Stock Solutions of Miconazole nitrate

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.0877 mL 10.4384 mL 20.8768 mL 41.7537 mL 52.1921 mL
5 mM 0.4175 mL 2.0877 mL 4.1754 mL 8.3507 mL 10.4384 mL
10 mM 0.2088 mL 1.0438 mL 2.0877 mL 4.1754 mL 5.2192 mL
50 mM 0.0418 mL 0.2088 mL 0.4175 mL 0.8351 mL 1.0438 mL
100 mM 0.0209 mL 0.1044 mL 0.2088 mL 0.4175 mL 0.5219 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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Background on Miconazole nitrate

Miconazole Nitrate is an imidazole antifungal agent. Target: Antifungal Miconazole is an imidazole antifungal agent, developed by Janssen Pharmaceutica, commonly applied topically to the skin or to mucous membranes to cure fungal infections. It works by inhibiting the synthesis of ergosterol, a critical component of fungal cell membranes. It can also be used against certain species of Leishmania protozoa which are a type of unicellular parasite that also contain ergosterol in their cell membranes. In addition to its antifungal and antiparasitic actions, it also has some antibacterial properties. Miconazole is also used in Ektachrome film developing in the final rinse of the Kodak E-6 process and similar Fuji CR-56 process, replacing formaldehyde. Fuji Hunt also includes miconazole as a final rinse additive in their formulation of the C-41RA rapid access color negative developing process. From Wikipedia.

References:
[1]. http://en.wikipedia.org/wiki/Miconazole

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References on Miconazole nitrate

Effect of miconazole on intracellular Ca2+ levels and proliferation in human osteosarcoma cells.[Pubmed:15826876]

Life Sci. 2005 Mar 18;76(18):2091-101.

The effect of miconazole, an anti-fungal drug, on cytoplasmic free Ca2+ concentrations ([Ca2+]i) in human osteosarcoma cells (MG63) was explored by using the Ca2+-sensitive dye fura-2. Miconazole acted in a concentration-dependent manner with an EC50 of 75 microM. The Ca2+ signal comprised a gradual rise and a sustained elevation. Removal of extracellular Ca2+ reduced 50% of the signal. In Ca2+-free medium, the [Ca2+]i rise induced by 1 microM thapsigargin (an endoplasmic reticulum Ca2+ pump inhibitor) was completely inhibited by pretreatment with 20 microM miconazole. Pretreatment with thapsigargin partly inhibited miconazole-induced Ca2+ release. The miconazole-induced Ca2+ release was not changed by inhibition of phospholipase C with 2 microM U73122. By using tetrazolium as a fluorescent probe, it was shown that 10-100 microM miconazole decreased cell proliferation rate in a concentration-dependent manner. Collectively, this study shows that miconazole induces [Ca2+]i rises in human osteosarcoma cells via releasing Ca2+ mainly from the endoplasmic reticulum in a manner independent of phospholipase C activity, and by causing Ca2+ influx. Furthermore, miconazole may be cytotoxic to the cells at higher concentrations.

Description

Miconazole nitrate (R18134 nitrate) is an imidazole antifungal agent. Miconazole nitrate also has antibacterial effects.

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