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Monomethylsulochrin

CAS# 10056-14-1

Monomethylsulochrin

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Monomethylsulochrin: 5mg $828 In Stock
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Quality Control of Monomethylsulochrin

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Chemical structure

Monomethylsulochrin

3D structure

Chemical Properties of Monomethylsulochrin

Cas No. 10056-14-1 SDF Download SDF
PubChem ID 23872041 Appearance Powder
Formula C18H18O7 M.Wt 346.33
Type of Compound Phenols Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name methyl 5-hydroxy-2-(2-hydroxy-6-methoxy-4-methylbenzoyl)-3-methoxybenzoate
SMILES CC1=CC(=C(C(=C1)OC)C(=O)C2=C(C=C(C=C2C(=O)OC)O)OC)O
Standard InChIKey XJOBKBUGVMLSEJ-UHFFFAOYSA-N
Standard InChI InChI=1S/C18H18O7/c1-9-5-12(20)16(13(6-9)23-2)17(21)15-11(18(22)25-4)7-10(19)8-14(15)24-3/h5-8,19-20H,1-4H3
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Monomethylsulochrin

The cultures of a marine-derived fungus Aspergillus sp. B-F-2.

Biological Activity of Monomethylsulochrin

Description1. Monomethylsulochrin shows antimicrobial activity against Escherichia coli, Pseudomonas aeruginosa, Bacillus subtilis and Staphylococcus aureus. 2. Monomethylsulochrin shows moderately inhibitory effects on the human bacterial pathogen Helicobacter pylori with the MIC value of 28.9+/-0.1 microM.
TargetsAntifection

Monomethylsulochrin Dilution Calculator

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Monomethylsulochrin Molarity Calculator

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Preparing Stock Solutions of Monomethylsulochrin

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.8874 mL 14.4371 mL 28.8742 mL 57.7484 mL 72.1855 mL
5 mM 0.5775 mL 2.8874 mL 5.7748 mL 11.5497 mL 14.4371 mL
10 mM 0.2887 mL 1.4437 mL 2.8874 mL 5.7748 mL 7.2185 mL
50 mM 0.0577 mL 0.2887 mL 0.5775 mL 1.155 mL 1.4437 mL
100 mM 0.0289 mL 0.1444 mL 0.2887 mL 0.5775 mL 0.7219 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Monomethylsulochrin

A new diphenyl ether from marine-derived fungus Aspergillus sp. B-F-2.[Pubmed:16915822]

J Antibiot (Tokyo). 2006 Jun;59(6):362-5.

A new diphenyl ether dimethyl 2,3'-dimethylosoate (1) together with three known compounds Monomethylsulochrin (2), emodin (3), and questin (4) were isolated through bioassay-guided fractionations from the culture of a marine-derived fungus Aspergillus sp. B-F-2. The structures of these compounds were determined by spectroscopic methods. Cytotoxicities of compounds 1 and 2 against K562 cell line were preliminarily evaluated by the MTT method and flow cytometry.

Benzophenones from Guignardia sp. IFB-E028, an endophyte on Hopea hainanensis.[Pubmed:20087992]

Chem Biodivers. 2010 Jan;7(1):216-20.

The first natural S-containing benzophenone dimer, named guignasulfide (3), was isolated from the culture of Guignardia sp. IFB-E028, an endophytic fungus residing in healthy leaves of Hopea hainanensis. Its structure was determined through correlative analyses of its MS, 1D- and 2D-NMR spectroscopic data. Two other known benzophenone derivatives, Monomethylsulochrin and rhizoctonic acid (1 and 2, resp.) were also isolated. Guignasulfide (3) was more active against the human liver cancer cell line HepG2 (IC(50) value: 5.2+/-0.4 microM) than metabolites 1 and 2 (IC(50) values: 63.5+/-0.6 and 60.2+/-0.5 microM); compounds 1-3 showed also moderately inhibitory effects on the human bacterial pathogen Helicobacter pylori with MIC values of 28.9+/-0.1, 60.2+/-0.4, and 42.9+/-0.5 microM, respectively.

Chemical constituents of Aspergillus sp EJC08 isolated as endophyte from Bauhinia guianensis and their antimicrobial activity.[Pubmed:24141408]

An Acad Bras Cienc. 2013;85(4):1247-53.

The present work reports the isolation of five compounds from Aspergillus sp EJC08 isolated as endophytic from Bauhinia guianensis, a tipical plant of the Amazon. The compounds ergosterol (1), ergosterol peroxide (2), mevalolactone (3), Monomethylsulochrin (4) and trypacidin A (5) were isolated by chromatographic procedures and identified by spectral methods of 1D and 2D NMR and MS. Compounds 3, 4 and 5 were tested against Escherichia coli, Pseudomonas aeruginosa, Bacillus subtilis and Staphylococcus aureus and showed good activity.

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