Pedunsaponin A

CAS# 250613-27-5

Pedunsaponin A

Catalog No. BCN8192----Order now to get a substantial discount!

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Quality Control of Pedunsaponin A

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Chemical structure

Pedunsaponin A

3D structure

Chemical Properties of Pedunsaponin A

Cas No. 250613-27-5 SDF Download SDF
PubChem ID 101223684 Appearance Powder
Formula C42H66O15 M.Wt 811.0
Type of Compound Triterpenoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (2S,3S,4S,5R,6R)-6-[[(3S,4R,4aR,6aR,6bS,7R,8aS,12aS,14aR,14bR)-7-hydroxy-4-(hydroxymethyl)-4,6a,6b,8a,11,11,14b-heptamethyl-8-oxo-2,3,4a,5,6,7,9,10,12,12a,14,14a-dodecahydro-1H-picen-3-yl]oxy]-3,5-dihydroxy-4-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxane-2-carboxylic acid
SMILES CC1(CCC2(C(C1)C3=CCC4C5(CCC(C(C5CCC4(C3(C(C2=O)O)C)C)(C)CO)OC6C(C(C(C(O6)C(=O)O)O)OC7C(C(C(C(O7)CO)O)O)O)O)C)C)C
Standard InChIKey QAZTYSZGLJXCHN-PFVMXIPDSA-N
Standard InChI InChI=1S/C42H66O15/c1-37(2)14-15-38(3)20(16-37)19-8-9-23-39(4)12-11-24(40(5,18-44)22(39)10-13-41(23,6)42(19,7)33(51)32(38)50)55-36-29(49)30(28(48)31(57-36)34(52)53)56-35-27(47)26(46)25(45)21(17-43)54-35/h8,20-31,33,35-36,43-49,51H,9-18H2,1-7H3,(H,52,53)/t20-,21+,22+,23+,24-,25+,26-,27+,28-,29+,30-,31-,33-,35-,36+,38-,39-,40-,41+,42-/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Pedunsaponin A

The herbs of Pueraria peduncularis

Biological Activity of Pedunsaponin A

Description1. Pedunsaponin A , a novel molluscicidal compound, exhibits strong toxicity against Pomacea canaliculata. 2. Pedunsaponin A has significant toxic effects on different organs of the snail.

Pedunsaponin A Dilution Calculator

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Pedunsaponin A Molarity Calculator

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Preparing Stock Solutions of Pedunsaponin A

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.233 mL 6.1652 mL 12.3305 mL 24.6609 mL 30.8261 mL
5 mM 0.2466 mL 1.233 mL 2.4661 mL 4.9322 mL 6.1652 mL
10 mM 0.1233 mL 0.6165 mL 1.233 mL 2.4661 mL 3.0826 mL
50 mM 0.0247 mL 0.1233 mL 0.2466 mL 0.4932 mL 0.6165 mL
100 mM 0.0123 mL 0.0617 mL 0.1233 mL 0.2466 mL 0.3083 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Pedunsaponin A

Histopathological effects of Pedunsaponin A on Pomacea canaliculata.[Pubmed:29891366]

Pestic Biochem Physiol. 2018 Jun;148:151-158.

Pedunsaponin A, a novel molluscicidal compound isolated from Pueraria peduncularis, exhibits strong toxicity against Pomacea canaliculata. To determine the mechanisms of Pedunsaponin A toxicity, its effects on the organs and hemocytes of P. canaliculata were examined in this study. The results showed that Pedunsaponin A had significant toxic effects on different organs of the snail, including the lungs, gills, mantle, siphon tube, ventricle, pericardial cavity, hepatopancreas, kidneys, and the major symptom of this toxicity was the loss of cilia in the lungs and gills. Additionally, in further studies on the effects of Pedunsaponin A treatment, we found that the hemocyte count was changed and hemocyte morphology was damaged, which was primarily reflected by cytoplasm leakage, nuclei deformation, and significant reductions in the number of ribosomes and granulocyte mitochondria. Based on these results and considering that blood vessels are distributed in the lungs and gills, we hypothesized that Pedunsaponin A would first destroy the cilia, which disrupt physiological activities such as respiration, excretion and feeding, and then enter the hemolymph through blood vessels, disrupt the normal function of the hemocytes and destroy the snail immune system, eventually resulting in the death of the snail.

Active saponins from root of Pueraria peduncularis (Grah. ex Benth.) Benth. and their molluscicidal effects on Pomacea canaliculata.[Pubmed:27608163]

Pest Manag Sci. 2017 Jun;73(6):1143-1147.

BACKGROUND: Pueraria peduncularis (Grah. ex Benth.) Benth., which belongs to the Leguminosae family, exhibits resistance to many crop pests in agricultural production. Pomacea canaliculata is an important invasive snail in rice fields and causes severe yield losses. To evaluate the toxicity of P. peduncularis to P. canaliculata, in this study the molluscicidal activity of root extracts of P. peduncularis was tested against P. canaliculata; the active compounds were isolated, and the structures of these compounds were analysed using nuclear magnetic resonance (NMR) analysis and mass spectral analysis. RESULTS: Our results showed that the molluscicidal activity of the root crude extract differed between P. canaliculata with different shell diameters after treatment for 72 h. The median lethal concentration (LC50 ) was 5.511 mg L(-1) against snails of 1.5 +/- 0.2 cm diameter and 12.383 mg L(-1) against snails of 2.5 +/- 0.2 cm diameter. Furthermore, two active ingredients isolated from root methanol extracts were identified as Pedunsaponin A and pedunsaponin C. Both Pedunsaponin A and pedunsaponin C showed strong molluscicidal activities, with LC50 values of 3.893 and 4.252 mg L(-1) , respectively, against snails with shell diameters of 1.5 +/- 0.2 cm after treatment for 72 h. CONCLUSION: Pueraria peduncularis extracts exhibit high molluscicidal activity and have great potential value for exploring a molluscicide to control Pomacea canaliculata. (c) 2016 Society of Chemical Industry.

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