Soyasaponin BbCAS# 51330-27-9 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 51330-27-9 | SDF | Download SDF |
| PubChem ID | 122097 | Appearance | White powder |
| Formula | C48H78O18 | M.Wt | 943.12 |
| Type of Compound | Triterpenoids | Storage | Desiccate at -20°C |
| Synonyms | Soyasaponin B-I; Soyasaponin I | ||
| Solubility | Soluble in methan | ||
| Chemical Name | (2S,3S,4S,5R,6R)-6-[[(3S,4S,4aR,6aR,6bS,8aR,9R,12aS,14aR,14bR)-9-hydroxy-4-(hydroxymethyl)-4,6a,6b,8a,11,11,14b-heptamethyl-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-yl]oxy]-5-[(2S,3R,4S,5R,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxy-3,4-dihydroxyoxane-2-carboxylic acid | ||
| SMILES | CC1C(C(C(C(O1)OC2C(C(C(OC2OC3C(C(C(OC3OC4CCC5(C(C4(C)CO)CCC6(C5CC=C7C6(CCC8(C7CC(CC8O)(C)C)C)C)C)C)C(=O)O)O)O)CO)O)O)O)O)O | ||
| Standard InChIKey | PTDAHAWQAGSZDD-IOVCITQVSA-N | ||
| Standard InChI | InChI=1S/C48H78O18/c1-21-29(52)31(54)35(58)40(61-21)65-37-32(55)30(53)24(19-49)62-41(37)66-38-34(57)33(56)36(39(59)60)64-42(38)63-28-12-13-45(5)25(46(28,6)20-50)11-14-48(8)26(45)10-9-22-23-17-43(2,3)18-27(51)44(23,4)15-16-47(22,48)7/h9,21,23-38,40-42,49-58H,10-20H2,1-8H3,(H,59,60)/t21-,23-,24+,25+,26+,27+,28-,29-,30-,31+,32-,33-,34-,35+,36-,37+,38+,40-,41-,42+,44+,45-,46+,47+,48+/m0/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | Soyasaponin Bb can suppress Eca-9706 cell growth, reverse effects on over expression of c-met, VEGF, and induce cell apoptosis through inhibiting HDAC1-NF-kappaB and activating PETEN and caspase-3 signaling pathways. |
| Targets | Caspase | VEGFR | HDAC | c-Met | NF-kB |
| In vitro | Apoptosis effects on human esophageal cancer cells by soyasaponin Bb and its machanism.[Pubmed: 20726234]Wei Sheng Yan Jiu. 2010 Jul;39(4):444-6.To explore the effect and potential mechanism of apoptosis in the Eca-9706 cells induced by Soyasaponin Bb.
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| Structure Identification | Anal Sci. 2015;31(2):85-9.Simple and rapid separation of soyasaponin Bb from a soy extract.[Pubmed: 25746805]A simple method to separate Soyasaponin Bb from a soy extract is presented. |
Soyasaponin Bb Dilution Calculator
Soyasaponin Bb Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 1.0603 mL | 5.3016 mL | 10.6031 mL | 21.2062 mL | 26.5078 mL |
| 5 mM | 0.2121 mL | 1.0603 mL | 2.1206 mL | 4.2412 mL | 5.3016 mL |
| 10 mM | 0.106 mL | 0.5302 mL | 1.0603 mL | 2.1206 mL | 2.6508 mL |
| 50 mM | 0.0212 mL | 0.106 mL | 0.2121 mL | 0.4241 mL | 0.5302 mL |
| 100 mM | 0.0106 mL | 0.053 mL | 0.106 mL | 0.2121 mL | 0.2651 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Simple and rapid separation of soyasaponin Bb from a soy extract.[Pubmed:25746805]
Anal Sci. 2015;31(2):85-9.
A simple method to separate Soyasaponin Bb from a soy extract is presented. This method is based on the difference in the solubility of Soyasaponin Bb and Ba and other components into 3:7 and 1:1 (v/v) acetone-water mixed solvents. The crude soyasaponin consisting of soyasaponins Aa, Ab, Ba, and Bb at the 10 wt% level and other components was examined as the soy extract. A 10 mg quantity of the crude soyasaponin was mixed with 1 mL of the 3:7 acetone-water containing 0.1 mol/L HCl, and the supernatant was removed to obtain a precipitate, which was found to contain mainly soyasaponins Bb and Ba. The precipitate was mixed with 0.4 mL of the 1:1 acetone-water containing 0.1 mol/L HCl; the supernatant was transferred, and was mixed with 0.6 mL of water to obtain a precipitate, which was found to contain mainly Soyasaponin Bb. The yield was ca. 30%, which may be much higher than that by the conventional preparative chromatographic approach. The separation method is rapid and easy to carry out, and is useful for the preparation of a Soyasaponin Bb sample.
[Apoptosis effects on human esophageal cancer cells by soyasaponin Bb and its machanism].[Pubmed:20726234]
Wei Sheng Yan Jiu. 2010 Jul;39(4):444-6.
OBJECTIVE: To explore the effect and potential mechanism of apoptosis in the Eca-9706 cells induced by Soyasaponin Bb. METHODS: Different concentrations of Soyasaponin Bb were on the Eca-9706 cell. Cell growth suppression rate was detected by MTT. Apoptotic rate was detected by TUNEL. The expression changes of HDAC1, NF-kappaB, PTEN, cyclin D1, c-met, VEGF or caspase-3 in the SSBb were detected by immunohistochemistry and immunoblotting. RESULTS: Compared with the control group, the growth-inhibition rate and apoptotic rate were increased, the expressions of PTEN, caspase 3 were increased, the expressions of c-met, VEGF, HDAC1, NF-kappaB and cyclin D1 were decreased. CONCLUSION: SSBb can suppress Eca-9706 cell growth. SSBb can exhibit reverse effects on over expression of c-met, VEGF in Eca-9706 cells. Eca-9706 cell apoptosis can be induced by SSBb through inhibiting HDAC1-NF-kappaB and activating PETEN and caspase-3 signaling pathways.
