Pinocembrin

CAS# 480-39-7

Pinocembrin

Catalog No. BCN5556----Order now to get a substantial discount!

Product Name & Size Price Stock
Pinocembrin: 5mg $23 In Stock
Pinocembrin: 10mg Please Inquire In Stock
Pinocembrin: 20mg Please Inquire Please Inquire
Pinocembrin: 50mg Please Inquire Please Inquire
Pinocembrin: 100mg Please Inquire Please Inquire
Pinocembrin: 200mg Please Inquire Please Inquire
Pinocembrin: 500mg Please Inquire Please Inquire
Pinocembrin: 1000mg Please Inquire Please Inquire
Related Products

Quality Control of Pinocembrin

Number of papers citing our products

Chemical structure

Pinocembrin

3D structure

Chemical Properties of Pinocembrin

Cas No. 480-39-7 SDF Download SDF
PubChem ID 68071 Appearance White powder
Formula C15H12O4 M.Wt 256.3
Type of Compound Flavonoids Storage Desiccate at -20°C
Synonyms Dihydrochrysin; 5,7-Dihydroxyflavanone; Galangin flavanone
Solubility Soluble in ethanol and methan
Chemical Name (2S)-5,7-dihydroxy-2-phenyl-2,3-dihydrochromen-4-one
SMILES C1C(OC2=CC(=CC(=C2C1=O)O)O)C3=CC=CC=C3
Standard InChIKey URFCJEUYXNAHFI-ZDUSSCGKSA-N
Standard InChI InChI=1S/C15H12O4/c16-10-6-11(17)15-12(18)8-13(19-14(15)7-10)9-4-2-1-3-5-9/h1-7,13,16-17H,8H2/t13-/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Pinocembrin

1 Glycyrrhiza sp. 2 Lippia sp. 3 Pinus sp. 4 Populus sp.

Biological Activity of Pinocembrin

DescriptionPinocembrin is a major flavonoid molecule incorporated as multifunctional in the pharmaceutical industry. Its vast range of pharmacological activities has been well researched including antimicrobial, neuroprotective, anti-inflammatory, antioxidant, and anticancer activities. Pinocembrin inhibited LPS-induced inflammatory mediators production by suppressing PI3K/Akt/NF-κB signaling pathway, it also inhibited TGF-β1-induced epithelial-mesenchymal transition (EMT) and metastasis of Y-79 cells by inactivating the αvβ3 integrin/FAK/p38α signaling pathway.
TargetsTNF-α | IL Receptor | NF-kB | NO | PGE | NO | COX | PI3K | Akt | Nrf2 | HO-1 | ERK | Beta Amyloid | TGF-β/Smad | FAK | p38MAPK | MMP(e.g.TIMP) | Antifection
In vitro

Pinocembrin inhibits lipopolysaccharide-induced inflammatory mediators production in BV2 microglial cells through suppression of PI3K/Akt/NF-κB pathway.[Pubmed: 26049009]

Eur J Pharmacol. 2015 Jun 3;761:211-216.

Pinocembrin, one of the primary flavonoids from Pinus heartwood and Eucalyptus, has been reported to have anti-inflammatory and antioxidant activity.
METHODS AND RESULTS:
This study was designed to evaluate the inhibitory effects of Pinocembrin on inflammatory mediators production in LPS-stimulated BV2 microglial cells. The results showed that Pinocembrin dose-dependently inhibited LPS-induced inflammatory mediators TNF-α, IL-1β, NO and PGE2 production. Pinocembrin also inhibited LPS-induced iNOS and COX-2 expression. Moreover, Pinocembrin inhibited LPS-induced PI3K, Akt phosphorylation, and NF-κB activation, which were required for inflammatory mediators production. Furthermore, treatment of Pinocembrin induced nuclear translocation of Nrf2 and expression of HO-1.
CONCLUSIONS:
In conclusion, our data indicated that Pinocembrin inhibited LPS-induced inflammatory mediators production by suppressing PI3K/Akt/NF-κB signaling pathway.

Pinocembrin: An antifungal compound secreted by leaf glands of eastern cottonwood.[Reference: WebLink]

Phytopathology, 1982, 72(7):877-80.

Pinocembrin: An antifungal compound secreted by leaf glands of eastern cottonwood

In vivo

Pinocembrin attenuates hippocampal inflammation, oxidative perturbations and apoptosis in a rat model of global cerebral ischemia reperfusion.[Pubmed: 25560584]

Pharmacol Rep. 2015 Feb;67(1):115-22.

Pinocembrin is a major flavonoid molecule isolated from honey and propolis. It has versatile pharmacological and biological activities including antimicrobial, anti-inflammatory, antioxidant, and anticancer activities as well as neuroprotective effects against cerebral ischemic injury. The purpose of the current study was to determine the possible mechanisms of neuroprotection elicited by Pinocembrin with specific emphasis on chronic prophylactic use before the induction of global cerebral ischemia reperfusion.
METHODS AND RESULTS:
Global cerebral ischemia-reperfusion (I/R) was induced by bilateral carotid artery occlusion for 15min followed by 60min reperfusion period. Animals were randomly allocated into 3 groups (n=28): Sham operated, I/R control and rats treated with Pinocembrin (10mg/kg, po) daily for 7 days then I/R was induced 1h after the last dose of Pinocembrin. After reperfusion rats were killed by decapitation, brains were removed and both hippocampi separated and the following biochemical parameters were estimated; lactate dehydrogenase activity, oxidative stress markers (lipid peroxides, nitric oxide and reduced glutathione), inflammatory markers (myeloperoxidase, tumor necrosis factor-alpha, nuclear factor kappa-B, interleukin-6 and interleukin-10), apoptotic biomarkers (caspase 3 and cytochrome C), neurotransmitters (glutamate, gamma aminobutyric acid) and infarct size were assessed. Pinocembrin ameliorated damage induced by I/R through suppressing oxidative stress, inflammatory and apoptotic markers as well as mitigating glutamate and lactate dehydrogenase activity. One of the more significant findings to emerge from this study is that Pinocembrin normalized the infarct size elevated by I/R.
CONCLUSIONS:
Pinocembrin showed a neuroprotective effects through antioxidant, anti-inflammatory and antiapoptotic mechanisms.

Pinocembrin protects the brain against ischemia-reperfusion injury and reverses the autophagy dysfunction in the penumbra area.[Pubmed: 25271424]

Molecules. 2014 Sep 30;19(10):15786-98.

The aim of this study was to investigate the effects of Pinocembrin on brain ischemia/reperfusion (I/R) injury and the potential involvement of autophagy activity changes in the penumbra area in the mechanisms of Pinocembrin activity.
METHODS AND RESULTS:
Focal cerebral I/R model was induced by middle cerebral artery occlusion (MCAO) for 2 h followed by 24 h reperfusion. Pinocembrin was administered intravenously at different doses (1, 3, and 10 mg/kg, respectively) at the onset of reperfusion. Neurological function, brain infarction and brain swelling ratio were evaluated. Terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) method and immunohistochemical analysis (Caspase-3) were used to evaluate apoptosis in the penumbra cortex. Two key proteins of autophagy, LC3B and Beclin1, were detected by western blot. The results showed that Pinocembrin-treatment could significantly reduce neurological deficit scores, infarct volume, cerebral edema and improve pathological lesion in the I/R rats. Pinocembrin-treatment could also reduce the number of TUNEL-positive and Caspase-3-positive neurons, and upregulate the expression of LC3B and Beclin1 in penumbra area.
CONCLUSIONS:
These results suggested that Pinocembrin could protect the brain against I/R injury, and the possible mechanisms might be attributed to inhibition of apoptosis and reversed autophagy activity in penumbra area.

Protocol of Pinocembrin

Cell Research

Pinocembrin suppresses TGF-β1-induced epithelial-mesenchymal transition and metastasis of human Y-79 retinoblastoma cells through inactivating αvβ3 integrin/FAK/p38α signaling pathway.[Pubmed: 25949790]

Cell Biosci. 2014 Aug 12;4:41.

Pinocembrin is the most abundant flavonoid in propolis. In this study, we investigated the antimetastatic effect of Pinocembrin on TGF-β1-induced epithelial-mesenchymal transition (EMT) and metastasis of human Y-79 retinoblastoma cells.
METHODS AND RESULTS:
Firstly, the results showed that Pinocembrin significantly suppresses the TGF-β1-induced abilities of the invasion and migration of Y-79 cells under non-cytotoxic concentration. Pinocembrin decreased TGF-β1-induced expression of vimentin, N-cadherin, αv and β3 integrin in Y-79 cells. Molecular data also showed Pinocembrin inhibits the activation of focal adhesion kinase (FAK) and p38α signal involved in the downregulation of enzyme activities, protein and messenger RNA levels of matrix metalloproteinase-2/9 (MMP-2/-9) induced by TGF-β1. Next, Pinocembrin also strongly inhibited the degradation of inhibitor of kappaBα (IκBα) and the nuclear levels of nuclear factor kappa B (NF-κB). Also, a dose-dependent inhibition on the binding ability of NF-κB was further observed under Pinocembrin treatment.
CONCLUSIONS:
Presented results indicated that Pinocembrin inhibits TGF-β1-induced epithelial-mesenchymal transition (EMT) and metastasis of Y-79 cells by inactivating the αvβ3 integrin/FAK/p38α signaling pathway. Thus, our findings point to the anticancer potential of Pinocembrin against retinoblastoma cells.

Animal Research

Pinocembrin improves cognition and protects the neurovascular unit in Alzheimer related deficits.[Pubmed: 24468471]

Neurobiol Aging. 2014 Jun;35(6):1275-85.

Amyloid-β (Aβ) peptides accumulate in the brain and initiate a cascade of pathologic events in Alzheimer's disease. The receptor for advanced glycation end products (RAGE) has been implicated to mediate Aβ-induced perturbations in the neurovascular unit (NVU). We demonstrated that Pinocembrin exhibits neuroprotection through inhibition of the Aβ and/or RAGE pathway, but the therapeutic role and mechanism involved are not ascertained.
METHODS AND RESULTS:
Here, we report that a 3-month treatment with Pinocembrin prevents the cognition decline in APP/PS1 transgenic mice without altering Aβ burden and oxidative stress. Instead, Pinocembrin is effective in conferring neurovascular protection through maintenance of neuropil ultrastructure, reduction of glial activation and levels of inflammatory mediators, preservation of microvascular function, improving the cholinergic system by conserving the ERK-CREB-BDNF pathway, and modulation of RAGE-mediated transduction. Furthermore, in an in vitro model, Pinocembrin provides the NVU protection against fibrillar Aβ₁₋₄₂, accompanied by regulation of neurovascular RAGE pathways.
CONCLUSIONS:
Our findings indicate that Pinocembrin improves cognition, at least in part, attributable to the NVU protection, and highlights Pinocembrin as a potential therapeutic strategy for the prevention and/or treatment of Alzheimer's disease.

Pinocembrin Dilution Calculator

Concentration (start)
x
Volume (start)
=
Concentration (final)
x
Volume (final)
 
 
 
C1
V1
C2
V2

calculate

Pinocembrin Molarity Calculator

Mass
=
Concentration
x
Volume
x
MW*
 
 
 
g/mol

calculate

Preparing Stock Solutions of Pinocembrin

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.9017 mL 19.5084 mL 39.0168 mL 78.0336 mL 97.5419 mL
5 mM 0.7803 mL 3.9017 mL 7.8034 mL 15.6067 mL 19.5084 mL
10 mM 0.3902 mL 1.9508 mL 3.9017 mL 7.8034 mL 9.7542 mL
50 mM 0.078 mL 0.3902 mL 0.7803 mL 1.5607 mL 1.9508 mL
100 mM 0.039 mL 0.1951 mL 0.3902 mL 0.7803 mL 0.9754 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Organizitions Citing Our Products recently

 
 
 

Calcutta University

University of Minnesota

University of Maryland School of Medicine

University of Illinois at Chicago

The Ohio State University

University of Zurich

Harvard University

Colorado State University

Auburn University

Yale University

Worcester Polytechnic Institute

Washington State University

Stanford University

University of Leipzig

Universidade da Beira Interior

The Institute of Cancer Research

Heidelberg University

University of Amsterdam

University of Auckland
TsingHua University
TsingHua University
The University of Michigan
The University of Michigan
Miami University
Miami University
DRURY University
DRURY University
Jilin University
Jilin University
Fudan University
Fudan University
Wuhan University
Wuhan University
Sun Yat-sen University
Sun Yat-sen University
Universite de Paris
Universite de Paris
Deemed University
Deemed University
Auckland University
Auckland University
The University of Tokyo
The University of Tokyo
Korea University
Korea University
Featured Products
  • Pinostrobin

    Catalog No.:BCN5555
    CAS No.:480-37-5
  • Linarin

    Catalog No.:BCN5554
    CAS No.:480-36-4
  • Eugenin

    Catalog No.:BCN2921
    CAS No.:480-34-2
  • Mellein

    Catalog No.:BCN4785
    CAS No.:480-33-1
  • Orobol

    Catalog No.:BCN5553
    CAS No.:480-23-9
  • Aromadendrin

    Catalog No.:BCN5552
    CAS No.:480-20-6
  • Isorhamnetin

    Catalog No.:BCN5551
    CAS No.:480-19-3
  • Taxifolin

    Catalog No.:BCN5550
    CAS No.:480-18-2
  • Morin

    Catalog No.:BCN1028
    CAS No.:480-16-0
  • Izalpinine

    Catalog No.:BCN3682
    CAS No.:480-14-8
  • Oroxylin A

    Catalog No.:BCN5363
    CAS No.:480-11-5
  • Astragalin

    Catalog No.:BCN5549
    CAS No.:480-10-4
New Products
 

References on Pinocembrin

Pinocembrin attenuates hippocampal inflammation, oxidative perturbations and apoptosis in a rat model of global cerebral ischemia reperfusion.[Pubmed:25560584]

Pharmacol Rep. 2015 Feb;67(1):115-22.

BACKGROUND: Pinocembrin is a major flavonoid molecule isolated from honey and propolis. It has versatile pharmacological and biological activities including antimicrobial, anti-inflammatory, antioxidant, and anticancer activities as well as neuroprotective effects against cerebral ischemic injury. The purpose of the current study was to determine the possible mechanisms of neuroprotection elicited by Pinocembrin with specific emphasis on chronic prophylactic use before the induction of global cerebral ischemia reperfusion. METHODS: Global cerebral ischemia-reperfusion (I/R) was induced by bilateral carotid artery occlusion for 15min followed by 60min reperfusion period. Animals were randomly allocated into 3 groups (n=28): Sham operated, I/R control and rats treated with Pinocembrin (10mg/kg, po) daily for 7 days then I/R was induced 1h after the last dose of Pinocembrin. After reperfusion rats were killed by decapitation, brains were removed and both hippocampi separated and the following biochemical parameters were estimated; lactate dehydrogenase activity, oxidative stress markers (lipid peroxides, nitric oxide and reduced glutathione), inflammatory markers (myeloperoxidase, tumor necrosis factor-alpha, nuclear factor kappa-B, interleukin-6 and interleukin-10), apoptotic biomarkers (caspase 3 and cytochrome C), neurotransmitters (glutamate, gamma aminobutyric acid) and infarct size were assessed. RESULTS: Pinocembrin ameliorated damage induced by I/R through suppressing oxidative stress, inflammatory and apoptotic markers as well as mitigating glutamate and lactate dehydrogenase activity. One of the more significant findings to emerge from this study is that Pinocembrin normalized the infarct size elevated by I/R. CONCLUSIONS: Pinocembrin showed a neuroprotective effects through antioxidant, anti-inflammatory and antiapoptotic mechanisms.

Pinocembrin suppresses TGF-beta1-induced epithelial-mesenchymal transition and metastasis of human Y-79 retinoblastoma cells through inactivating alphavbeta3 integrin/FAK/p38alpha signaling pathway.[Pubmed:25949790]

Cell Biosci. 2014 Aug 12;4:41.

BACKGROUND: Pinocembrin is the most abundant flavonoid in propolis. In this study, we investigated the antimetastatic effect of Pinocembrin on TGF-beta1-induced epithelial-mesenchymal transition (EMT) and metastasis of human Y-79 retinoblastoma cells. RESULTS: Firstly, the results showed that Pinocembrin significantly suppresses the TGF-beta1-induced abilities of the invasion and migration of Y-79 cells under non-cytotoxic concentration. Pinocembrin decreased TGF-beta1-induced expression of vimentin, N-cadherin, alphav and beta3 integrin in Y-79 cells. Molecular data also showed Pinocembrin inhibits the activation of focal adhesion kinase (FAK) and p38alpha signal involved in the downregulation of enzyme activities, protein and messenger RNA levels of matrix metalloproteinase-2/9 (MMP-2/-9) induced by TGF-beta1. Next, Pinocembrin also strongly inhibited the degradation of inhibitor of kappaBalpha (IkappaBalpha) and the nuclear levels of nuclear factor kappa B (NF-kappaB). Also, a dose-dependent inhibition on the binding ability of NF-kappaB was further observed under Pinocembrin treatment. CONCLUSIONS: Presented results indicated that Pinocembrin inhibits TGF-beta1-induced epithelial-mesenchymal transition (EMT) and metastasis of Y-79 cells by inactivating the alphavbeta3 integrin/FAK/p38alpha signaling pathway. Thus, our findings point to the anticancer potential of Pinocembrin against retinoblastoma cells.

Pinocembrin inhibits lipopolysaccharide-induced inflammatory mediators production in BV2 microglial cells through suppression of PI3K/Akt/NF-kappaB pathway.[Pubmed:26049009]

Eur J Pharmacol. 2015 Aug 15;761:211-6.

Pinocembrin, one of the primary flavonoids from Pinus heartwood and Eucalyptus, has been reported to have anti-inflammatory and antioxidant activity. This study was designed to evaluate the inhibitory effects of Pinocembrin on inflammatory mediators production in LPS-stimulated BV2 microglial cells. The results showed that Pinocembrin dose-dependently inhibited LPS-induced inflammatory mediators TNF-alpha, IL-1beta, NO and PGE2 production. Pinocembrin also inhibited LPS-induced iNOS and COX-2 expression. Moreover, Pinocembrin inhibited LPS-induced PI3K, Akt phosphorylation, and NF-kappaB activation, which were required for inflammatory mediators production. Furthermore, treatment of Pinocembrin induced nuclear translocation of Nrf2 and expression of HO-1. In conclusion, our data indicated that Pinocembrin inhibited LPS-induced inflammatory mediators production by suppressing PI3K/Akt/NF-kappaB signaling pathway.

Pinocembrin protects the brain against ischemia-reperfusion injury and reverses the autophagy dysfunction in the penumbra area.[Pubmed:25271424]

Molecules. 2014 Sep 30;19(10):15786-98.

The aim of this study was to investigate the effects of Pinocembrin on brain ischemia/reperfusion (I/R) injury and the potential involvement of autophagy activity changes in the penumbra area in the mechanisms of Pinocembrin activity. Focal cerebral I/R model was induced by middle cerebral artery occlusion (MCAO) for 2 h followed by 24 h reperfusion. Pinocembrin was administered intravenously at different doses (1, 3, and 10 mg/kg, respectively) at the onset of reperfusion. Neurological function, brain infarction and brain swelling ratio were evaluated. Terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) method and immunohistochemical analysis (Caspase-3) were used to evaluate apoptosis in the penumbra cortex. Two key proteins of autophagy, LC3B and Beclin1, were detected by western blot. The results showed that Pinocembrin-treatment could significantly reduce neurological deficit scores, infarct volume, cerebral edema and improve pathological lesion in the I/R rats. Pinocembrin-treatment could also reduce the number of TUNEL-positive and Caspase-3-positive neurons, and upregulate the expression of LC3B and Beclin1 in penumbra area. These results suggested that Pinocembrin could protect the brain against I/R injury, and the possible mechanisms might be attributed to inhibition of apoptosis and reversed autophagy activity in penumbra area.

Pinocembrin improves cognition and protects the neurovascular unit in Alzheimer related deficits.[Pubmed:24468471]

Neurobiol Aging. 2014 Jun;35(6):1275-85.

Amyloid-beta (Abeta) peptides accumulate in the brain and initiate a cascade of pathologic events in Alzheimer's disease. The receptor for advanced glycation end products (RAGE) has been implicated to mediate Abeta-induced perturbations in the neurovascular unit (NVU). We demonstrated that Pinocembrin exhibits neuroprotection through inhibition of the Abeta and/or RAGE pathway, but the therapeutic role and mechanism involved are not ascertained. Here, we report that a 3-month treatment with Pinocembrin prevents the cognition decline in APP/PS1 transgenic mice without altering Abeta burden and oxidative stress. Instead, Pinocembrin is effective in conferring neurovascular protection through maintenance of neuropil ultrastructure, reduction of glial activation and levels of inflammatory mediators, preservation of microvascular function, improving the cholinergic system by conserving the ERK-CREB-BDNF pathway, and modulation of RAGE-mediated transduction. Furthermore, in an in vitro model, Pinocembrin provides the NVU protection against fibrillar Abeta(1)(-)(4)(2), accompanied by regulation of neurovascular RAGE pathways. Our findings indicate that Pinocembrin improves cognition, at least in part, attributable to the NVU protection, and highlights Pinocembrin as a potential therapeutic strategy for the prevention and/or treatment of Alzheimer's disease.

Keywords:

Pinocembrin,480-39-7,Dihydrochrysin; 5,7-Dihydroxyflavanone; Galangin flavanone,Natural Products, buy Pinocembrin , Pinocembrin supplier , purchase Pinocembrin , Pinocembrin cost , Pinocembrin manufacturer , order Pinocembrin , high purity Pinocembrin

Online Inquiry for:

      Fill out the information below

      • Size:Qty: - +

      * Required Fields

                                      Result: