S-Sulfo-L-cysteine sodium saltGroup I agonist CAS# 7381-67-1 |
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Quality Control & MSDS
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| Cas No. | 7381-67-1 | SDF | Download SDF |
| PubChem ID | 23675751 | Appearance | Powder |
| Formula | C3H6NO5S2Na | M.Wt | 223.19 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | Soluble to 100 mM in water | ||
| Chemical Name | sodium;(2R)-2-amino-3-sulfosulfanylpropanoate | ||
| SMILES | C(C(C(=O)[O-])N)SS(=O)(=O)O.[Na+] | ||
| Standard InChIKey | DQFVBELGDROGDO-DKWTVANSSA-M | ||
| Standard InChI | InChI=1S/C3H7NO5S2.Na/c4-2(3(5)6)1-10-11(7,8)9;/h2H,1,4H2,(H,5,6)(H,7,8,9);/q;+1/p-1/t2-;/m0./s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | EAA receptor agonist. Agonist at mGlu1α and mGlu5a subtypes expressed in clonal RGT cell lines. |
S-Sulfo-L-cysteine sodium salt Dilution Calculator
S-Sulfo-L-cysteine sodium salt Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 4.4805 mL | 22.4024 mL | 44.8049 mL | 89.6097 mL | 112.0122 mL |
| 5 mM | 0.8961 mL | 4.4805 mL | 8.961 mL | 17.9219 mL | 22.4024 mL |
| 10 mM | 0.448 mL | 2.2402 mL | 4.4805 mL | 8.961 mL | 11.2012 mL |
| 50 mM | 0.0896 mL | 0.448 mL | 0.8961 mL | 1.7922 mL | 2.2402 mL |
| 100 mM | 0.0448 mL | 0.224 mL | 0.448 mL | 0.8961 mL | 1.1201 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Sulphur-containing amino acids are agonists for group 1 metabotropic receptors expressed in clonal RGT cell lines.[Pubmed:9681926]
Neuropharmacology. 1998;37(3):277-87.
Comparison of the pharmacological effects of a range of sulphur-containing amino acids on human mGluR1alpha and mGluR5a has been undertaken. cDNAs of each mGluR were transfected into a Syrian hamster tumour cell line AV12-664 that was previously transfected with the rat glutamate-aspartate transporter protein (GLAST). The L-isomers of cysteine sulphinic acid (CSA), homocysteine sulphinic acid (HCSA), cysteic acid (CA) and serine-O-sulphate (SOS) stimulated PI hydrolysis in human mGluR1alpha and mGluR5a cells with full agonist effects. D-CSA, the only active D-isomer, was a partial agonist for mGluR5a whereas L-sulphocysteine (S-CYS) showed weak agonist-like effects at high concentrations on both mGluR1alpha and mGluR5a. L-Homocysteic acid was inactive on both mGluR1alpha and mGluR5a cells. Treatment of mGluR cultures with glutamate pyruvate transaminase did not alter the potencies of the S-amino acids on PI hydrolysis responses. Inhibitor constants (Ki) obtained for L-HCSA, L-CSA, L-CA and L-SOS in [3H]glutamate receptor binding studies with mGluR1alpha cells indicated that L-HCSA, L-CSA, L-CA and L-SOS can bind specifically to mGluR1 with L-HCSA showing the highest affinity. These results confirm that certain endogenously produced S-amino acids may interact directly with group 1 mGluRs.
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