SR 8278CAS# 1254944-66-5 |
- PA-824
Catalog No.:BCC1106
CAS No.:187235-37-6
- Clofazimine
Catalog No.:BCC4651
CAS No.:2030-63-9
- 5-hydroxypyrazine-2-carboxylic acid
Catalog No.:BCC1311
CAS No.:34604-60-9
- Nitazoxanide
Catalog No.:BCC3824
CAS No.:55981-09-4
- Sodium 4-Aminosalicylate
Catalog No.:BCC4609
CAS No.:6018-19-5
- Rifapentine
Catalog No.:BCC4937
CAS No.:61379-65-5
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
Cas No. | 1254944-66-5 | SDF | Download SDF |
PubChem ID | 53393127 | Appearance | Powder |
Formula | C18H19NO3S2 | M.Wt | 361.48 |
Type of Compound | N/A | Storage | Desiccate at -20°C |
Solubility | Soluble to 100 mM in DMSO and to 50 mM in ethanol | ||
Chemical Name | ethyl 2-(5-methylsulfanylthiophene-2-carbonyl)-3,4-dihydro-1H-isoquinoline-3-carboxylate | ||
SMILES | CCOC(=O)C1CC2=CC=CC=C2CN1C(=O)C3=CC=C(S3)SC | ||
Standard InChIKey | UIEBLUZPSFAFOC-UHFFFAOYSA-N | ||
Standard InChI | InChI=1S/C18H19NO3S2/c1-3-22-18(21)14-10-12-6-4-5-7-13(12)11-19(14)17(20)15-8-9-16(23-2)24-15/h4-9,14H,3,10-11H2,1-2H3 | ||
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. |
Description | Rev-Erbα antagonist; inhibits Rev-Erbα transcriptional repression (EC50 = 0.47 μM). Blocks activity of Rev-Erbα agonist GSK 4112 in HEK293 cells. Increases expression of glucose-regulating genes, G6Pase and PEPCK in HepG2 cells. |
SR 8278 Dilution Calculator
SR 8278 Molarity Calculator
1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
1 mM | 2.7664 mL | 13.832 mL | 27.664 mL | 55.3281 mL | 69.1601 mL |
5 mM | 0.5533 mL | 2.7664 mL | 5.5328 mL | 11.0656 mL | 13.832 mL |
10 mM | 0.2766 mL | 1.3832 mL | 2.7664 mL | 5.5328 mL | 6.916 mL |
50 mM | 0.0553 mL | 0.2766 mL | 0.5533 mL | 1.1066 mL | 1.3832 mL |
100 mM | 0.0277 mL | 0.1383 mL | 0.2766 mL | 0.5533 mL | 0.6916 mL |
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. |
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
- Sibutramine hydrochloride monohydrate
Catalog No.:BCC5251
CAS No.:125494-59-9
- Saclofen
Catalog No.:BCC6580
CAS No.:125464-42-8
- LY2874455
Catalog No.:BCC1723
CAS No.:1254473-64-7
- RQ-00203078
Catalog No.:BCC6419
CAS No.:1254205-52-1
- Acetate gossypol
Catalog No.:BCN5354
CAS No.:12542-36-8
- TCN 238
Catalog No.:BCC7901
CAS No.:125404-04-8
- Cedrelone
Catalog No.:BCN6135
CAS No.:1254-85-9
- 6-Acetonyl-N-methyl-dihydrodecarine
Catalog No.:BCN6134
CAS No.:1253740-09-8
- AbK
Catalog No.:BCC8011
CAS No.:1253643-88-7
- NMS-E973
Catalog No.:BCC5335
CAS No.:1253584-84-7
- Antiquorin
Catalog No.:BCN7163
CAS No.:125356-08-3
- N-Debenzoyl-N-(tert-butoxycarbonyl)taxol
Catalog No.:BCN1592
CAS No.:125354-16-7
- Testosterone phenylpropionate
Catalog No.:BCC9171
CAS No.:1255-49-8
- Dracorhodin perchlorate
Catalog No.:BCN2628
CAS No.:125536-25-6
- 3',5,5',7-Tetrahydroxy-4',6-dimethoxyflavone
Catalog No.:BCN6136
CAS No.:125537-92-0
- LY 233053
Catalog No.:BCC5771
CAS No.:125546-04-5
- PF-4708671
Catalog No.:BCC5031
CAS No.:1255517-76-0
- UNC0638
Catalog No.:BCC1135
CAS No.:1255580-76-7
- MnTMPyP Pentachloride
Catalog No.:BCC6532
CAS No.:125565-45-9
- Rotigotine hydrochloride
Catalog No.:BCC1908
CAS No.:125572-93-2
- [Leu31,Pro34]-Neuropeptide Y (porcine)
Catalog No.:BCC5716
CAS No.:125580-28-1
- TRX818
Catalog No.:BCC6458
CAS No.:1256037-58-7
- AI-10-49
Catalog No.:BCC3973
CAS No.:1256094-72-0
- RuBi-Nicotine
Catalog No.:BCC7793
CAS No.:1256362-30-7
Identification of SR8278, a synthetic antagonist of the nuclear heme receptor REV-ERB.[Pubmed:21043485]
ACS Chem Biol. 2011 Feb 18;6(2):131-4.
REV-ERBalpha is a member of the nuclear receptor superfamily that functions as a receptor for the porphoryin heme. REV-ERBalpha suppresses transcription of its target genes in a heme-dependent manner. Recently, the first nonporphyrin synthetic ligand for REV-ERBalpha, GSK4112, was designed, and it mimics the action of heme acting as agonist. Here, we report the identification of the first REV-ERB antagonist, SR8278. SR8278 is structurally similar to the agonist but blocks the ability of the GSK4112 to enhance REV-ERBalpha-dependent repression in a cotransfection assay. Additionally, whereas GSK4112 suppresses the expression of REV-ERBalpha target genes involved in gluconeogenesis, SR8278 stimulates the expression of these genes. Thus, SR8278 represents a unique chemical tool for probing REV-ERB function and may serve as a point for initiation of further optimization to develop REV-ERB antagonists with the ability to explore circadian and metabolic functions.