SavininCAS# 493-95-8 |
Quality Control & MSDS
3D structure
Package In Stock
Number of papers citing our products
| Cas No. | 493-95-8 | SDF | Download SDF |
| PubChem ID | 5281867 | Appearance | Powder |
| Formula | C20H16O6 | M.Wt | 352.3 |
| Type of Compound | Lignans | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | (3E,4R)-4-(1,3-benzodioxol-5-ylmethyl)-3-(1,3-benzodioxol-5-ylmethylidene)oxolan-2-one | ||
| SMILES | C1C(C(=CC2=CC3=C(C=C2)OCO3)C(=O)O1)CC4=CC5=C(C=C4)OCO5 | ||
| Standard InChIKey | CMJGAYUQSLJSCR-ULIPXBITSA-N | ||
| Standard InChI | InChI=1S/C20H16O6/c21-20-15(6-13-2-4-17-19(8-13)26-11-24-17)14(9-22-20)5-12-1-3-16-18(7-12)25-10-23-16/h1-4,6-8,14H,5,9-11H2/b15-6+/t14-/m0/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 1. Savinin has antiinflammatory effect, can significantly inhibit tumor necrosis factor (TNF)-a production in lipopolysaccharide (LPS)-stimulated RAW264.7 cells, and T cell proliferation elicited by concanavalin (Con A), without displaying cytotoxicity. 2. Savinin exhibits potent spermicidal activity and significant insecticidal activity. |
| Targets | TNF-α |
Savinin Dilution Calculator
Savinin Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.8385 mL | 14.1924 mL | 28.3849 mL | 56.7698 mL | 70.9622 mL |
| 5 mM | 0.5677 mL | 2.8385 mL | 5.677 mL | 11.354 mL | 14.1924 mL |
| 10 mM | 0.2838 mL | 1.4192 mL | 2.8385 mL | 5.677 mL | 7.0962 mL |
| 50 mM | 0.0568 mL | 0.2838 mL | 0.5677 mL | 1.1354 mL | 1.4192 mL |
| 100 mM | 0.0284 mL | 0.1419 mL | 0.2838 mL | 0.5677 mL | 0.7096 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
- α-D-Glucose
Catalog No.:BCC9197
CAS No.:492-62-6
- Kynurenic acid
Catalog No.:BCN2228
CAS No.:492-27-3
- Butin
Catalog No.:BCN4630
CAS No.:492-14-8
- Plathymenin
Catalog No.:BCN6810
CAS No.:492-12-6
- (+)-Sparteine
Catalog No.:BCC9249
CAS No.:492-08-0
- Thermopsidine
Catalog No.:BCN7923
CAS No.:492-02-4
- TCS PIM-1 1
Catalog No.:BCC2447
CAS No.:491871-58-0
- Hemokinin 1 (human)
Catalog No.:BCC5923
CAS No.:491851-53-7
- Biochanin A
Catalog No.:BCN1224
CAS No.:491-80-5
- Iridin
Catalog No.:BCN6868
CAS No.:491-74-7
- Chrysoeriol
Catalog No.:BCN5601
CAS No.:491-71-4
- Luteolin
Catalog No.:BCN5600
CAS No.:491-70-3
- Methyl L-pyroglutamate
Catalog No.:BCN7060
CAS No.:4931-66-2
- Nifuratel
Catalog No.:BCC1800
CAS No.:4936-47-4
- Isoammodendrine
Catalog No.:BCN2146
CAS No.:494-15-5
- Nornicotine
Catalog No.:BCN8176
CAS No.:494-97-3
- TC-G 1001
Catalog No.:BCC6316
CAS No.:494191-73-0
- Ginsenoside Rk1
Catalog No.:BCN3552
CAS No.:494753-69-4
- Auraptene
Catalog No.:BCN5603
CAS No.:495-02-3
- Ammijin
Catalog No.:BCN3617
CAS No.:495-30-7
- Nodakenin
Catalog No.:BCN2378
CAS No.:495-31-8
- Nodakenetin
Catalog No.:BCN5604
CAS No.:495-32-9
- Desoxypeganine
Catalog No.:BCN8032
CAS No.:495-59-0
- Tropine isobutyrate
Catalog No.:BCN1923
CAS No.:495-80-7
Savinin, a lignan from Pterocarpus santalinus inhibits tumor necrosis factor-alpha production and T cell proliferation.[Pubmed:11217086]
Biol Pharm Bull. 2001 Feb;24(2):167-71.
Two lignans were isolated from the heartwood of Pterocarpus santalinus by activity-guided fractionation and investigated for their biological properties and molecular mechanism of action. On the basis of their spectroscopic data, these compounds were identified as Savinin (1) and calocedrin (2), dibenzyl butyrolactone-type lignan compounds having an alpha-arylidene gamma-lactone structure. These lignans significantly inhibited tumor necrosis factor (TNF)-a production in lipopolysaccharide (LPS)-stimulated RAW264.7 cells, and T cell proliferation elicited by concanavalin (Con A), without displaying cytotoxicity. The molecular inhibitory mechanism of compound 1 was confirmed to be mediated by the non-polar butyrolactone ring, according to a structure-relationship study with structurally related and unrelated compounds, such as arctigenin (a dibenzyl butyrolactone type lignan), eudesmin (a furofuran type lignan), isolariciresinol (a dibenzylbutane type lignan), and cynaropicrin (a sesquiterpene lactone). The results suggest that Savinin may act as an active principle in the reported biological activities of P. santalinus, such as antiinflammatory effect, by mediation of the butyrolactone ring as a valuable pharmacophore.
Antimicrobial alkaloids from Zanthoxylum tetraspermum and caudatum.[Pubmed:11324918]
Phytochemistry. 2001 Apr;56(8):857-61.
Two benzophenanthrene alkaloids, 8-acetonyldihydronitidine and 8-acetonyldihydroavicine were isolated from Zanthoxylum tetraspermum stem bark along with liriodenine, sesamin, lichexanthone and (+)-piperitol-gamma,gamma-dimethylallylether. The species endemic to Sri Lanka, Z. caudatum, contained sesamin, Savinin, liriodenine, decarine and 8-O-desmethyl-N-nornitidine. 8-Acetonyldihydronitidine and 8-acetonyldihydroavicine showed significant antibacterial activity while the former along with liriodenine was strongly antifungal. Savinin exhibited potent spermicidal activity. Both Savinin and sesamin exhibited significant insecticidal activity.
