Plathymenin

CAS# 492-12-6

Plathymenin

Catalog No. BCN6810----Order now to get a substantial discount!

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Quality Control of Plathymenin

Number of papers citing our products

Chemical structure

Plathymenin

3D structure

Chemical Properties of Plathymenin

Cas No. 492-12-6 SDF Download SDF
PubChem ID 102196479 Appearance Powder
Formula C15H12O6 M.Wt 288.25
Type of Compound Flavonoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name (2S)-2-(3,4-dihydroxyphenyl)-6,7-dihydroxy-2,3-dihydrochromen-4-one
SMILES C1C(OC2=CC(=C(C=C2C1=O)O)O)C3=CC(=C(C=C3)O)O
Standard InChIKey ZIKILYZOICUSQT-AWEZNQCLSA-N
Standard InChI InChI=1S/C15H12O6/c16-9-2-1-7(3-11(9)18)14-5-10(17)8-4-12(19)13(20)6-15(8)21-14/h1-4,6,14,16,18-20H,5H2/t14-/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Plathymenin

The herbs of Spatholobus suberectus

Biological Activity of Plathymenin

TargetsNF-kB | TNF-α | IL Receptor | Tyrosinase | IkB | IKK

Plathymenin Dilution Calculator

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Plathymenin Molarity Calculator

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Preparing Stock Solutions of Plathymenin

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.4692 mL 17.3461 mL 34.6921 mL 69.3842 mL 86.7303 mL
5 mM 0.6938 mL 3.4692 mL 6.9384 mL 13.8768 mL 17.3461 mL
10 mM 0.3469 mL 1.7346 mL 3.4692 mL 6.9384 mL 8.673 mL
50 mM 0.0694 mL 0.3469 mL 0.6938 mL 1.3877 mL 1.7346 mL
100 mM 0.0347 mL 0.1735 mL 0.3469 mL 0.6938 mL 0.8673 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Plathymenin

Bioactive constituents of Spatholobus suberectus in regulating tyrosinase-related proteins and mRNA in HEMn cells.[Pubmed:16782143]

Phytochemistry. 2006 Jun;67(12):1262-70.

Spatholobus suberectus Dunn (Leguminosae) is a traditional Chinese herbal medicine used to treat rheumatism, anemia, menoxenia, and other disorders. The extent to which this herbal medicine is useful to skin cells, however, has not been evaluated. Constituents of the 95% ethanol extracts of the dried vine stems of S. suberectus were therefore isolated and examined for their skin-whitening capacity. A bio-guided phytochemical investigation, involving use of the mushroom tyrosinase inhibitory system, of active fractions of the extracts resulted in the isolation of 12 constituents. The structures of these constituents, which were characterized by various spectroscopic techniques, consisted of one flavone, three isoflavones, five flavanones, two flavanonols, and one chalcone. Of these constituents 3',4',7-trihydroxyflavone (1), eriodictyol (3), Plathymenin (5), dihydroquercetin (6), butin (7), neoisoliquiritigenin (8), dihydrokaempferol (9), liquiritigenin (10), and 6-methoxyeriodictyol (12) represented compounds isolated for the first time from S. suberectus. These constituents were evaluated their ability to inhibit cellular tyrosinase activity and for their melanin inhibitory activity in human epidermal melanocytes (HEMn). Butin (7) was the most efficacious of these constituents and exhibited concentration-dependent effects. Western blot analysis revealed that expression of tyrosinase and tyrosinase-related proteins 1 and 2 (TRP1 and TRP2) was decreased in butin (7)-treated HEMn cells. Additionally, quantitative real-time PCR (qRT-PCR) analysis disclosed that expression of mRNAs for tyrosinase, TRP1 and TRP2 was suppressed by butin (7). It is concluded that butin (7) is the most active of the components of S. suberectus in inhibiting pigmentation and that this inhibition is exerted through inhibition of transcription of the genes encoding tyrosinase, TRP1 and TRP2.

Anti-inflammatory activity of flavonoids in Nepalese propolis is attributed to inhibition of the IL-33 signaling pathway.[Pubmed:25614224]

Int Immunopharmacol. 2015 Mar;25(1):189-98.

Propolis has been used in folk medicine to improve health and prevent inflammatory diseases; however, the components that exhibit its anti-inflammatory activity remain unknown. We herein investigated the effects of flavonoids isolated from Nepalese propolis on the IL-33 signaling pathway to clarify the anti-inflammatory mechanism involved. Of the 8 types of flavonoids isolated from Nepalese propolis, 4 types of compounds, such as 3',4'-dihydroxy-4-methoxydalbergione, 4-methoxydalbergion, cearoin, and chrysin, markedly inhibited the IL-33-induced mRNA expression of inflammatory genes including IL-6, TNFalpha and IL-13 in bone marrow-derived mast cells (BMMC). These four flavonoids also inhibited the IL-33-induced activation of nuclear factor kappaB (NF-kappaB), which was consistent with their inhibitory effects on cytokine expression. The effects of these flavonoids are attributed to inhibition of IL-33-induced activation of IKK, which leads to the degradation of IkappaBalpha and nuclear localization of NF-kappaB. On the other hand, other flavonoids isolated from Nepalese propolis, such as isoliquiritigenin, Plathymenin, 7-hydroxyflavanone, and (+)-medicarpin, had no effect on the IL-33 signaling pathway or cytokine expression. Therefore, these results indicate that 3',4'-dihydroxy-4-methoxydalbergione, 4-methoxydalbergion, cearoin, and chrysin are the substances responsible for the anti-inflammatory activity of Nepalese propolis.

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