Schiarisanrin ACAS# 130252-41-4 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 130252-41-4 | SDF | Download SDF |
| PubChem ID | 145709656.0 | Appearance | Powder |
| Formula | C27H32O8 | M.Wt | 484.5 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | [(1S,12R,13R,14R)-18,19-dimethoxy-13,14-dimethyl-20-oxo-3,6,8-trioxapentacyclo[9.9.1.01,16.04,21.05,9]henicosa-4(21),5(9),10,16,18-pentaen-12-yl] (2S)-2-methylbutanoate | ||
| SMILES | CCC(C)C(=O)OC1C(C(CC2=CC(=C(C(=O)C23COC4=C3C1=CC5=C4OCO5)OC)OC)C)C | ||
| Standard InChIKey | JHTGXHCLRHKLER-ZPNZURAVSA-N | ||
| Standard InChI | InChI=1S/C27H32O8/c1-7-13(2)26(29)35-21-15(4)14(3)8-16-9-18(30-5)23(31-6)25(28)27(16)11-32-24-20(27)17(21)10-19-22(24)34-12-33-19/h9-10,13-15,21H,7-8,11-12H2,1-6H3/t13-,14+,15+,21+,27-/m0/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
Schiarisanrin A Dilution Calculator
Schiarisanrin A Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 2.064 mL | 10.3199 mL | 20.6398 mL | 41.2797 mL | 51.5996 mL |
| 5 mM | 0.4128 mL | 2.064 mL | 4.128 mL | 8.2559 mL | 10.3199 mL |
| 10 mM | 0.2064 mL | 1.032 mL | 2.064 mL | 4.128 mL | 5.16 mL |
| 50 mM | 0.0413 mL | 0.2064 mL | 0.4128 mL | 0.8256 mL | 1.032 mL |
| 100 mM | 0.0206 mL | 0.1032 mL | 0.2064 mL | 0.4128 mL | 0.516 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
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Schizandra arisanensis extract attenuates cytokine-mediated cytotoxicity in insulin-secreting cells.[Pubmed:23239919]
World J Gastroenterol. 2012 Dec 14;18(46):6809-18.
AIM: To explore the bioactivity of an ethanolic extract of Schizandra arisanensis (SA-Et) and isolated constituents against interleukin-1beta and interferon-gamma-mediated beta cell death and abolition of insulin secretion. METHODS: By employing BRIN-BD11 cells, the effects of SA-Et administration on cytokine-mediated cell death and abolition of insulin secretion were evaluated by a viability assay, cell cycle analysis, and insulin assay. The associated gene and protein expressions were also measured. In addition, the bioactivities of several peak compounds collected from the SA-Et were tested against cytokine-mediated beta cell death. RESULTS: Our results revealed that SA-Et dose-dependently ameliorated cytokine-mediated beta cell death and apoptosis. Instead of suppressing inducible nitric oxide synthase/nitric oxide cascade or p38MAPK activity, suppression of stress-activated protein kinase/c-Jun NH2-terminal kinase activity appeared to be the target for SA-Et against the cytokine mix. In addition, SA-Et provided some insulinotropic effects which re-activated the abolished insulin exocytosis in cytokine-treated BRIN-BD11 cells. Finally, Schiarisanrin A and B isolated from the SA-Et showed a dose-dependent protective effect against cytokine-mediated beta cell death. CONCLUSION: This is the first report on SA-Et ameliorating cytokine-mediated beta cell death and dysfunction via anti-apoptotic and insulinotropic actions.
Four New C19 Homolignans, Schiarisanrins A, B, and D and Cytotoxic Schiarisanrin C, from Schizandra arisanensis.[Pubmed:11671710]
J Org Chem. 1997 May 16;62(10):3242-3245.
Four new C(19) homolignans with a 5,4'-butano-2,4-cyclohexadienone-6-spiro-3'-(2',3'-dihydrobenzo[b]furan) skeleton, Schiarisanrin A, schiarisanrin B, schiarisanrin D, and cytotoxic schiarisanrin C, were isolated from Schizandra arisanensis. Their structure and stereochemistry have been established by spectral and single-crystal X-ray analysis. Schiarisanrin C has cytotoxic activity with ED(50) values of 0.36, 7.1, 4.9, and 5.7 &mgr;g/mL, respectively, against KB epidermoid carcinoma of nasopharynx, COLO-205 colon carcinoma, HEPA hepatoma, and HELA cervix tumor cells.
