ScoparoneCAS# 120-08-1 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
Cas No. | 120-08-1 | SDF | Download SDF |
PubChem ID | 8417 | Appearance | Powder |
Formula | C11H10O4 | M.Wt | 206.2 |
Type of Compound | Coumarins | Storage | Desiccate at -20°C |
Synonyms | Aesculetin dimethyl ether; 6,7-Dimethoxycoumarin; 6,7-Dimethylesculetin; Escoparone; Esculetin 6,7-dimethyl ether; O-Methylisoscopoletin; O-Methylscopoletin; Scopoletin methyl ether | ||
Solubility | >8.4mg/mL in DMSO | ||
Chemical Name | 6,7-dimethoxychromen-2-one | ||
SMILES | COC1=C(C=C2C(=C1)C=CC(=O)O2)OC | ||
Standard InChIKey | GUAFOGOEJLSQBT-UHFFFAOYSA-N | ||
Standard InChI | InChI=1S/C11H10O4/c1-13-9-5-7-3-4-11(12)15-8(7)6-10(9)14-2/h3-6H,1-2H3 | ||
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. |
Description | Scoparone is a phytoalexin with antifungal,anticoagulant, antianginal, hypolipidemic, vasorelaxant, immunosuppression, hepatoprotective,anti-allergic,antioxidant, and anti-inflammatory actions, it is used for the traditional treatment of neonatal jaundice. It inhibited the activities of PPARγ, STAT3, NADPH-oxidase 1, and the expression of ERK,NF-kB, JNK,PI3K. It augmented the expression of SOD1 and CAT. |
Targets | NF-kB | ERK | ROS | PI3K | STAT | PPAR | IL Receptor | TNF-α |
In vitro | Scoparone attenuates RANKL-induced osteoclastic differentiation through controlling reactive oxygen species production and scavenging.[Pubmed: 25576385]Exp Cell Res. 2015 Feb 15;331(2):267-77.Scoparone, one of the bioactive components of Artemisia capillaris Thunb, has various biological properties including immunosuppressive, hepatoprotective, anti-allergic, anti-inflammatory, and antioxidant effects.
Scoparone inhibits adipocyte differentiation through down-regulation of peroxisome proliferators-activated receptor γ in 3T3-L1 preadipocytes.[Pubmed: 23790840]Food Chem. 2013 Nov 15;141(2):723-30.This study was performed to investigate the effect of Scoparone on the differentiation of 3T3-L1 preadipocytes. Accumulation of scoparone, a phytoalexin associated with resistance of citrus to Phytophthora citrophthora.[Reference: WebLink]Phytopathology, 1989, 78(12):1678-82.
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In vivo | The effect of scoparone, a coumarin derivative isolated from the Chinese crude drug Artemisiae capillaris flos, on the heart.[Pubmed: 2630096]Chem Pharm Bull (Tokyo). 1989 May;37(5):1297-9.
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Cell Research | Scoparone interferes with STAT3-induced proliferation of vascular smooth muscle cells.[Pubmed: 25744297]Exp Mol Med. 2015 Mar 6;47:e145.Scoparone, which is a major constituent of Artemisia capillaries, has been identified as an anticoagulant, hypolipidemic, vasorelaxant, anti-oxidant and anti-inflammatory drug, and it is used for the traditional treatment of neonatal jaundice.
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Animal Research | Protective effects of scoparone against lipopolysaccharide-induced acute lung injury.[Pubmed: 25151099]Int Immunopharmacol. 2014 Nov;23(1):127-33.
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Scoparone Dilution Calculator
Scoparone Molarity Calculator
1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
1 mM | 4.8497 mL | 24.2483 mL | 48.4966 mL | 96.9932 mL | 121.2415 mL |
5 mM | 0.9699 mL | 4.8497 mL | 9.6993 mL | 19.3986 mL | 24.2483 mL |
10 mM | 0.485 mL | 2.4248 mL | 4.8497 mL | 9.6993 mL | 12.1242 mL |
50 mM | 0.097 mL | 0.485 mL | 0.9699 mL | 1.9399 mL | 2.4248 mL |
100 mM | 0.0485 mL | 0.2425 mL | 0.485 mL | 0.9699 mL | 1.2124 mL |
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. |
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Scoparone inhibits adipocyte differentiation through down-regulation of peroxisome proliferators-activated receptor gamma in 3T3-L1 preadipocytes.[Pubmed:23790840]
Food Chem. 2013 Nov 15;141(2):723-30.
This study was performed to investigate the effect of Scoparone on the differentiation of 3T3-L1 preadipocytes. Scoparone inhibited triglyceride (TG) accumulation in the mature adipocytes, evidenced by Oil-red O staining and intracellular quantification. Real time-PCR analysis showed that Scoparone significantly down-regulated the mRNA expression of key adipogenic transcription factors, PPARgamma, C/EBPalpha, compared with mature adipocytes. Scoparone appeared to reduce mRNA expression of SREBP1c and FAS being related to the late stage of adipogenesis. Furthermore, aP2 and CD36/FAT, as adipocyte-specific genes, were decreased in mature adipocytes by Scoparone treatment. Moreover, Scoparone inhibited the up-regulated expression of PPARgamma target genes by rosiglitazone to near that observed in cells treated with GW9662. The luciferase assay revealed that Scoparone negatively regulates the transcriptional activity of PPARgamma. Chromatin immunoprecipitation assay also showed that participation of Scoparone in the regulation of PPARgamma. Collectively, Scoparone has a PPARgamma antagonic effect and suppresses differentiation through down-regulation of adipogenic genes by PPARgamma inhibition in 3T3-L1 preadipocytes.
Protective effects of scoparone against lipopolysaccharide-induced acute lung injury.[Pubmed:25151099]
Int Immunopharmacol. 2014 Nov;23(1):127-33.
The purpose of this study was to investigate the protective effects and molecular mechanisms of Scoparone on lipopolysaccharide (LPS)-induced acute lung injury in mice. Mice model of acute lung injury (ALI), induced by intranasal instillation of LPS, was used to investigate the protective effects of Scoparone in vivo. The alveolar macrophages were used to investigate the molecular mechanisms of Scoparone in vitro. The results showed that Scoparone treatment remarkably attenuated LPS-induced pulmonary edema, histological severities, myeloperoxidase activity, and TNF-alpha, IL-6 and IL-1beta production in vivo. We also found that Scoparone inhibited LPS-induced TLR4 expression, NF-kappaB activation, TNF-alpha, IL-6 and IL-1beta production in alveolar macrophages in vitro. In conclusion, our results suggest that Scoparone has a protective effect on LPS-induced ALI via suppression of TLR4-mediated NF-kappaB signaling pathways.
Scoparone attenuates RANKL-induced osteoclastic differentiation through controlling reactive oxygen species production and scavenging.[Pubmed:25576385]
Exp Cell Res. 2015 Feb 15;331(2):267-77.
Scoparone, one of the bioactive components of Artemisia capillaris Thunb, has various biological properties including immunosuppressive, hepatoprotective, anti-allergic, anti-inflammatory, and antioxidant effects. This study aims at evaluating the anti-osteoporotic effect of Scoparone and its underlying mechanism in vitro. Scoparone demonstrated potent cellular antioxidant capacity. It was also found that Scoparone inhibited the receptor activator of nuclear factor-kappaB ligand (RANKL)-induced osteoclast differentiation and suppressed cathepsin K and tartrate-resistant acid phosphatase (TRAP) expression via c-jun N-terminal kinase (JNK)/extracellular signal-regulated kinase (ERK)/p38-mediated c-Fos-nuclear factor of activated T cells, cytoplasmic 1 (NFATc1) signaling pathway. During osteoclast differentiation, the production of general reactive oxygen species (ROS) and superoxide anions was dose-dependently attenuated by Scoparone. In addition, Scoparone diminished NADPH (nicotinamide adenine dinucleotide phosphate) oxidase 1 (Nox1) expression and activation via the tumor necrosis factor receptor-associated factor 6 (TRAF6)-cSrc-phosphatidylinositol 3-kinase (PI3k) signaling pathway and prevented the disruption of mitochondrial electron transport chain system. Furthermore, Scoparone augmented the expression of superoxide dismutase 1 (SOD1) and catalase (CAT). The overall results indicate that the inhibitory effect of Scoparone on RANKL-induced osteoclast differentiation is attributed to the suppressive effect on ROS and superoxide anion production by inhibiting Nox1 expression and activation and protecting the mitochondrial electron transport chain system and the scavenging effect of ROS resulting from elevated SOD1 and CAT expression.
Scoparone interferes with STAT3-induced proliferation of vascular smooth muscle cells.[Pubmed:25744297]
Exp Mol Med. 2015 Mar 6;47:e145.
Scoparone, which is a major constituent of Artemisia capillaries, has been identified as an anticoagulant, hypolipidemic, vasorelaxant, anti-oxidant and anti-inflammatory drug, and it is used for the traditional treatment of neonatal jaundice. Therefore, we hypothesized that Scoparone could suppress the proliferation of VSMCs by interfering with STAT3 signaling. We found that the proliferation of these cells was significantly attenuated by Scoparone in a dose-dependent manner. Scoparone markedly reduced the serum-stimulated accumulation of cells in the S phase and concomitantly increased the proportion of cells in the G0/G1 phase, which was consistent with the reduced expression of cyclin D1, phosphorylated Rb and survivin in the VSMCs. Cell adhesion markers, such as MCP-1 and ICAM-1, were significantly reduced by Scoparone. Interestingly, this compound attenuated the increase in cyclin D promoter activity by inhibiting the activities of both the WT and active forms of STAT3. Similarly, the expression of a cell proliferation marker induced by PDGF was decreased by Scoparone with no change in the phosphorylation of JAK2 or Src. On the basis of the immunofluorescence staining results, STAT3 proteins phosphorylated by PDGF were predominantly localized to the nucleus and were markedly reduced in the Scoparone-treated cells. In summary, Scoparone blocks the accumulation of STAT3 transported from the cytosol to the nucleus, leading to the suppression of VSMC proliferation through G1 phase arrest and the inhibition of Rb phosphorylation. This activity occurs independent of the form of STAT3 and upstream of kinases, such as Jak and Src, which are correlated with abnormal vascular remodeling due to the presence of an excess of growth factors following vascular injury. These data provide convincing evidence that Scoparone may be a new preventative agent for the treatment of cardiovascular diseases.