SecurinineCAS# 5610-40-2 |
Quality Control & MSDS
3D structure
Package In Stock
Number of papers citing our products
| Cas No. | 5610-40-2 | SDF | Download SDF |
| PubChem ID | 201912 | Appearance | Light yellow powder |
| Formula | C13H15NO2 | M.Wt | 217.26 |
| Type of Compound | Alkaloids | Storage | Desiccate at -20°C |
| Solubility | DMSO : 2 mg/mL (9.21 mM; Need ultrasonic) | ||
| SMILES | C1CCN2C(C1)C34CC2C=CC3=CC(=O)O4.[N+](=O)(O)[O-] | ||
| Standard InChIKey | GTMBYDCKQUSFCT-DGKOSOBHSA-N | ||
| Standard InChI | InChI=1S/C13H15NO2.HNO3/c15-12-7-9-4-5-10-8-13(9,16-12)11-3-1-2-6-14(10)11;2-1(3)4/h4-5,7,10-11H,1-3,6,8H2;(H,2,3,4)/t10-,11+,13?;/m0./s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
| Description | 1. Securinine induces apoptosis in human leukemia HL-60 cells. 2. Securinine is a promising new monocytic differentiation inducing agent for Acute Myeloid Leukemia (AML) . 3. Securinine, a GABAA receptor antagonist, enhances macrophage clearance of phase II C. burnetii: comparison with TLR agonists. 4. Securinine shows antifungal activity against some plant pathogenic fungi. |
| Targets | TLR | IL Receptor | GABA Receptor |
Securinine Dilution Calculator
Securinine Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 4.6028 mL | 23.0139 mL | 46.0278 mL | 92.0556 mL | 115.0695 mL |
| 5 mM | 0.9206 mL | 4.6028 mL | 9.2056 mL | 18.4111 mL | 23.0139 mL |
| 10 mM | 0.4603 mL | 2.3014 mL | 4.6028 mL | 9.2056 mL | 11.507 mL |
| 50 mM | 0.0921 mL | 0.4603 mL | 0.9206 mL | 1.8411 mL | 2.3014 mL |
| 100 mM | 0.046 mL | 0.2301 mL | 0.4603 mL | 0.9206 mL | 1.1507 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
- Ionomycin calcium salt
Catalog No.:BCC5805
CAS No.:56092-82-1
- Ionomycin free acid
Catalog No.:BCC7261
CAS No.:56092-81-0
- 3-Methoxyshancigusin I
Catalog No.:BCC9002
CAS No.:
- PRIMA-1
Catalog No.:BCC2413
CAS No.:5608-24-2
- Hispidin
Catalog No.:BCN3567
CAS No.:56070-89-4
- Sucralose
Catalog No.:BCC4725
CAS No.:56038-13-2
- Eburicoic acid
Catalog No.:BCN2556
CAS No.:560-66-7
- 9-Hydroxy-4-androstene-3,17-dione
Catalog No.:BCC8802
CAS No.:560-62-3
- Chlorhexidine acetate
Catalog No.:BCC8912
CAS No.:56-95-1
- Histamine 2HCl
Catalog No.:BCC4530
CAS No.:56-92-8
- (H-Cys-OH)2
Catalog No.:BCC2915
CAS No.:56-89-3
- L-lysine
Catalog No.:BCN7157
CAS No.:56-87-1
- Parisaponin I
Catalog No.:BCN2835
CAS No.:561007-63-4
- Asperglaucide
Catalog No.:BCN5748
CAS No.:56121-42-7
- 4-O-Methylhelichrysetin
Catalog No.:BCN3986
CAS No.:56121-44-9
- Valrubicin
Catalog No.:BCC5219
CAS No.:56124-62-0
- H-Sar-OtBu.HCl
Catalog No.:BCC3336
CAS No.:5616-81-9
- Acarbose
Catalog No.:BCC1190
CAS No.:56180-94-0
- CGP 13501
Catalog No.:BCC7097
CAS No.:56189-68-5
- Terpinine-4-ol
Catalog No.:BCN8250
CAS No.:562-74-3
- Torsemide
Catalog No.:BCC4871
CAS No.:56211-40-6
- Methyl lycernuate A
Catalog No.:BCN5749
CAS No.:56218-46-3
- Porson
Catalog No.:BCN5750
CAS No.:56222-03-8
- Cyclo(Tyr-Gly)
Catalog No.:BCN2414
CAS No.:5625-49-0
Securinine induced apoptosis in human leukemia HL-60 cells.[Pubmed:10452105]
Zhongguo Yao Li Xue Bao. 1999 Mar;20(3):267-70.
AIM: To study whether Securinine might induce apoptosis in human leukemia HL-60 cells. METHODS: Inhibition of proliferation was measured using MTT assay. The amount of apoptotic cells was measured by flow cytometry. DNA fragmentation was visualized by DNA agarose gel electrophoresis and the cellular changes were observed by electron microscope. RESULTS: Securinine 5-80 mg.L-1 elicited typical apoptosis morphological changes and DNA fragmentation in a concentration-dependent manner in HL-60 cells. Securinine inhibited HL-60 cell proliferation in a time- and concentration-dependent manner. The IC50 and 95% confidence limits were 27 (15-47) mg.L-1 after 12-h treatment with Securinine. CONCLUSION: Securinine induced apoptosis in HL-60 cells.
Antifungal Activity of Securinine against Some Plant Pathogenic Fungi.[Pubmed:23990741]
Mycobiology. 2008 Jun;36(2):99-101.
The alkaloid Securinine was assessed against spore germination of some plant pathogenic and saprophytic fungi (Alternaria alternata, Alternaria brassicae, Alternaria brassicicola, Curvularia lunata, Curvularia maculans, Curvularia pallenscens, Colletotrichum musae, Colletotrichum sp., Erysiphe pisi, Helminthosporium echinoclova, Helminthosporium spiciferum, Heterosporium sp.). Spore germinations of all the tested fungi were inhibited. Alternaria brassicicola, C. lunata, C. pallenscens and H. spiciferum were highly sensitive as complete inhibition of spore germination was observed at very low concentrations (200 ppm).
Securinine, a myeloid differentiation agent with therapeutic potential for AML.[Pubmed:21731671]
PLoS One. 2011;6(6):e21203.
As the defining feature of Acute Myeloid Leukemia (AML) is a maturation arrest, a highly desirable therapeutic strategy is to induce leukemic cell maturation. This therapeutic strategy has the potential of avoiding the significant side effects that occur with the traditional AML therapeutics. We identified a natural compound Securinine, as a leukemia differentiation-inducing agent. Securinine is a plant-derived alkaloid that has previously been used clinically as a therapeutic for primarily neurological related diseases. Securinine induces monocytic differentiation of a wide range of myeloid leukemia cell lines as well as primary leukemic patient samples. Securinine's clinical potential for AML can be seen from its ability to induce significant growth arrest in cell lines and patient samples as well as its activity in significantly impairing the growth of AML tumors in nude mice. In addition, Securinine can synergize with currently employed agents such as ATRA and decitabine to induce differentiation. This study has revealed Securinine induces differentiation through the activation of DNA damage signaling. Securinine is a promising new monocytic differentiation inducing agent for AML that has seen previous clinical use for non-related disorders.
