Sodium 4-amiropparaty Hyalrate

Sodium 4-amiropparaty Hyalrate

Insights into metabolism and sodium chloride adaptability of carbaryl degrading halotolerant Pseudomonas sp. strain C7.[Pubmed:28374062]

Arch Microbiol. 2017 Aug;199(6):907-916.

Pseudomonas sp. strain C7 isolated from sediment of Thane creek near Mumbai, India, showed the ability to grow on glucose and carbaryl in the presence of 7.5 and 3.5% of NaCl, respectively. It also showed good growth in the absence of NaCl indicating the strain to be halotolerant. Increasing salt concentration impacted the growth on carbaryl; however, the specific activity of various enzymes involved in the metabolism remained unaffected. Among various enzymes, 1-naphthol 2-hydroxylase was found to be sensitive to chloride as compared to carbaryl hydrolase and gentisate 1,2-dioxygenase. The intracellular concentration of Cl(-) ions remained constant (6-8 mM) for cells grown on carbaryl either in the presence or absence of NaCl. Thus the ability to adapt to the increasing concentration of NaCl is probably by employing chloride efflux pump and/or increase in the concentration of osmolytes as mechanism for halotolerance. The halotolerant nature of the strain will be beneficial to remediate carbaryl from saline agriculture fields, ecosystems and wastewaters.

Pharmacodynamic properties and bioequivalence of dalteparin sodium subcutaneous injection in healthy Chinese male subjects.[Pubmed:28375032]

Xenobiotica. 2018 Apr;48(4):376-381.

1. Dalteparin sodium (DS) is a low molecular weight heparin that is widely used in the treatment of thromboembolism. The purpose of this study was to compare the pharmacodynamic properties and bioequivalence of the two formulations of DS with subcutaneous injection in healthy Chinese male subjects. 2. In this randomized, open-label, two-period crossover study, a total of 24 male subjects were recruited to receive single subcutaneous doses of test and reference DS injection in two different sequences (12 subjects each) with a seven-day washout period. Plasma samples were obtained at different time points after administration of the injection and measured by chromogenic substrate assay. The pharmacodynamic parameters including Emax, AUEC0-T, AUEC0-infinity and Tmax were analyzed to evaluate the bioequivalence of two DS formulations. 3. The relative bioequivalence was 107.7 +/- 15.5 and 106.6 +/- 29.8 for Anti-Xa and Anti-IIa, two major active metabolites of DS, respectively. The 90% confidence intervals (CIs) of the geometric mean ratio (test/reference) of Emax, AUEC0-T and AUEC0-infinity were 98.71-104.40%, 101.95-112.13% and 102.38-112.10% for Anti-Xa, and 100.88-110.42%, 95.76-112.62% and 92.24-111.32% for Anti-IIa, respectively, and all of the 90% CIs were within 80-125%. The T1/2 of reference and test were 2.88 +/- 1.21 h and 2.76 +/- 0.97 h for Anti-Xa, 1.87 +/- 0.62 h and 1.96 +/- 1.52 h for Anti-IIa. 4. Based on the pharmacodynamic parameters and FDA Guidance on DS and regulatory criteria for bioequivalence, the test and reference formulations were bioequivalent in healthy Chinese male subjects.

Improved Lithium-Ion and Sodium-Ion Storage Properties from Few-Layered WS2 Nanosheets Embedded in a Mesoporous CMK-3 Matrix.[Pubmed:28374501]

Chemistry. 2017 May 23;23(29):7074-7080.

An integrated WS2 @CMK-3 nanocomposite has been prepared by a one-step hydrothermal method and then used as the anode material for lithium-ion and sodium-ion batteries. Ultrathin WS2 nanosheets have been successfully embedded into the ordered mesoporous carbon (CMK-3) framework. Owing to the few-layered nanostructure of WS2 , as well as the high electronic conductivity and the volume confinement effect of CMK-3, the material shows larger discharge capacity, better rate capability, and improved cycle stability than pristine WS2 . When tested in lithium-ion batteries, the material delivers a reversible capacity of 720 mA h g(-1) after 100 cycles at a current density of 100 mA g(-1) . A large discharge capacity of 307 mA h g(-1) is obtained at a current density of 2 A g(-1) . When used in sodium-ion batteries, the material exhibits a capacity of 333 mA h g(-1) at 100 mA g(-1) without capacity fading after 70 cycles. A discharge capacity of 230 mA h g(-1) is obtained at 2 A g(-1) . This excellent performance demonstrates that the WS2 @CMK-3 nanocomposite has great potential as a high-performance anode material for next-generation rechargeable batteries.

The Influence of Sodium Fluoride on the Growth of Ameloblasts and Kidney Proximal Tubular Cells.[Pubmed:28374673]

Folia Biol (Praha). 2017;63(1):31-34.

Fluoride has toxic potential particularly for teeth, bones, and kidney. This study was aimed to investigate the NaF exposure effects on the growth of ameloblasts and kidney proximal tubular cells. Adult male healthy rats were used as experiment models, divided into control and NaF-induced groups. The expression of amelogenin, Bcl-2, and caspase-3 were significantly different in the control and NaF-induced group (P < 0.05). There was no correlation among these proteins in the control group but significant correlation in the NaF-induced group (r = 0.694). There was a significant correlation in proximal tubular cells, as seen from the increase of caspase-3 in the NaF-induced group (r = 0.715).

Aminohippurate sodium is a diagnostic agent useful in medical tests involving the kidney used in the measurement of renal plasma flow.

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