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Sodium 4-amiropparaty Hyalrate

CAS# 94-16-6

Sodium 4-amiropparaty Hyalrate

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Chemical structure

Sodium 4-amiropparaty Hyalrate

3D structure

Chemical Properties of Sodium 4-amiropparaty Hyalrate

Cas No. 94-16-6 SDF Download SDF
PubChem ID 443971 Appearance Powder
Formula C9H9N2NaO3 M.Wt 216.17
Type of Compound N/A Storage Desiccate at -20°C
Synonyms Sodium p-aminohippurate; p-Aminohippuric acid sodium salt
Solubility H2O : 100 mg/mL (462.60 mM; Need ultrasonic)
DMSO : ≥ 46 mg/mL (212.80 mM)
*"≥" means soluble, but saturation unknown.
Chemical Name sodium;2-[(4-aminobenzoyl)amino]acetate
SMILES C1=CC(=CC=C1C(=O)NCC(=O)[O-])N.[Na+]
Standard InChIKey UNZMYCAEMNVPHX-UHFFFAOYSA-M
Standard InChI InChI=1S/C9H10N2O3.Na/c10-7-3-1-6(2-4-7)9(14)11-5-8(12)13;/h1-4H,5,10H2,(H,11,14)(H,12,13);/q;+1/p-1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Biological Activity of Sodium 4-amiropparaty Hyalrate

DescriptionAminohippurate sodium is a diagnostic agent useful in medical tests involving the kidney used in the measurement of renal plasma flow.

References:
[1]. Naidoo V, et al. Diclofenac toxicity in Gyps vulture is associated with decreased uric acid excretion and not renal portal vasoconstriction. Comp Biochem Physiol C Toxicol Pharmacol. 2009 Apr;149(3):269-74.

Sodium 4-amiropparaty Hyalrate Dilution Calculator

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Sodium 4-amiropparaty Hyalrate Molarity Calculator

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Preparing Stock Solutions of Sodium 4-amiropparaty Hyalrate

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 4.626 mL 23.1299 mL 46.2599 mL 92.5198 mL 115.6497 mL
5 mM 0.9252 mL 4.626 mL 9.252 mL 18.504 mL 23.1299 mL
10 mM 0.4626 mL 2.313 mL 4.626 mL 9.252 mL 11.565 mL
50 mM 0.0925 mL 0.4626 mL 0.9252 mL 1.8504 mL 2.313 mL
100 mM 0.0463 mL 0.2313 mL 0.4626 mL 0.9252 mL 1.1565 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Sodium 4-amiropparaty Hyalrate

Insights into metabolism and sodium chloride adaptability of carbaryl degrading halotolerant Pseudomonas sp. strain C7.[Pubmed:28374062]

Arch Microbiol. 2017 Aug;199(6):907-916.

Pseudomonas sp. strain C7 isolated from sediment of Thane creek near Mumbai, India, showed the ability to grow on glucose and carbaryl in the presence of 7.5 and 3.5% of NaCl, respectively. It also showed good growth in the absence of NaCl indicating the strain to be halotolerant. Increasing salt concentration impacted the growth on carbaryl; however, the specific activity of various enzymes involved in the metabolism remained unaffected. Among various enzymes, 1-naphthol 2-hydroxylase was found to be sensitive to chloride as compared to carbaryl hydrolase and gentisate 1,2-dioxygenase. The intracellular concentration of Cl(-) ions remained constant (6-8 mM) for cells grown on carbaryl either in the presence or absence of NaCl. Thus the ability to adapt to the increasing concentration of NaCl is probably by employing chloride efflux pump and/or increase in the concentration of osmolytes as mechanism for halotolerance. The halotolerant nature of the strain will be beneficial to remediate carbaryl from saline agriculture fields, ecosystems and wastewaters.

Pharmacodynamic properties and bioequivalence of dalteparin sodium subcutaneous injection in healthy Chinese male subjects.[Pubmed:28375032]

Xenobiotica. 2018 Apr;48(4):376-381.

1. Dalteparin sodium (DS) is a low molecular weight heparin that is widely used in the treatment of thromboembolism. The purpose of this study was to compare the pharmacodynamic properties and bioequivalence of the two formulations of DS with subcutaneous injection in healthy Chinese male subjects. 2. In this randomized, open-label, two-period crossover study, a total of 24 male subjects were recruited to receive single subcutaneous doses of test and reference DS injection in two different sequences (12 subjects each) with a seven-day washout period. Plasma samples were obtained at different time points after administration of the injection and measured by chromogenic substrate assay. The pharmacodynamic parameters including Emax, AUEC0-T, AUEC0-infinity and Tmax were analyzed to evaluate the bioequivalence of two DS formulations. 3. The relative bioequivalence was 107.7 +/- 15.5 and 106.6 +/- 29.8 for Anti-Xa and Anti-IIa, two major active metabolites of DS, respectively. The 90% confidence intervals (CIs) of the geometric mean ratio (test/reference) of Emax, AUEC0-T and AUEC0-infinity were 98.71-104.40%, 101.95-112.13% and 102.38-112.10% for Anti-Xa, and 100.88-110.42%, 95.76-112.62% and 92.24-111.32% for Anti-IIa, respectively, and all of the 90% CIs were within 80-125%. The T1/2 of reference and test were 2.88 +/- 1.21 h and 2.76 +/- 0.97 h for Anti-Xa, 1.87 +/- 0.62 h and 1.96 +/- 1.52 h for Anti-IIa. 4. Based on the pharmacodynamic parameters and FDA Guidance on DS and regulatory criteria for bioequivalence, the test and reference formulations were bioequivalent in healthy Chinese male subjects.

Improved Lithium-Ion and Sodium-Ion Storage Properties from Few-Layered WS2 Nanosheets Embedded in a Mesoporous CMK-3 Matrix.[Pubmed:28374501]

Chemistry. 2017 May 23;23(29):7074-7080.

An integrated WS2 @CMK-3 nanocomposite has been prepared by a one-step hydrothermal method and then used as the anode material for lithium-ion and sodium-ion batteries. Ultrathin WS2 nanosheets have been successfully embedded into the ordered mesoporous carbon (CMK-3) framework. Owing to the few-layered nanostructure of WS2 , as well as the high electronic conductivity and the volume confinement effect of CMK-3, the material shows larger discharge capacity, better rate capability, and improved cycle stability than pristine WS2 . When tested in lithium-ion batteries, the material delivers a reversible capacity of 720 mA h g(-1) after 100 cycles at a current density of 100 mA g(-1) . A large discharge capacity of 307 mA h g(-1) is obtained at a current density of 2 A g(-1) . When used in sodium-ion batteries, the material exhibits a capacity of 333 mA h g(-1) at 100 mA g(-1) without capacity fading after 70 cycles. A discharge capacity of 230 mA h g(-1) is obtained at 2 A g(-1) . This excellent performance demonstrates that the WS2 @CMK-3 nanocomposite has great potential as a high-performance anode material for next-generation rechargeable batteries.

The Influence of Sodium Fluoride on the Growth of Ameloblasts and Kidney Proximal Tubular Cells.[Pubmed:28374673]

Folia Biol (Praha). 2017;63(1):31-34.

Fluoride has toxic potential particularly for teeth, bones, and kidney. This study was aimed to investigate the NaF exposure effects on the growth of ameloblasts and kidney proximal tubular cells. Adult male healthy rats were used as experiment models, divided into control and NaF-induced groups. The expression of amelogenin, Bcl-2, and caspase-3 were significantly different in the control and NaF-induced group (P < 0.05). There was no correlation among these proteins in the control group but significant correlation in the NaF-induced group (r = 0.694). There was a significant correlation in proximal tubular cells, as seen from the increase of caspase-3 in the NaF-induced group (r = 0.715).

Description

Aminohippurate sodium is a diagnostic agent useful in medical tests involving the kidney used in the measurement of renal plasma flow.

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