Sophoraflavanone HCAS# 136997-68-7 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
Cas No. | 136997-68-7 | SDF | Download SDF |
PubChem ID | 134715105 | Appearance | Powder |
Formula | C34H30O9 | M.Wt | 582.60 |
Type of Compound | Flavonoids | Storage | Desiccate at -20°C |
Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
Chemical Name | 2-[(2R,3R)-3-(3,5-dihydroxyphenyl)-6-hydroxy-2-(4-hydroxyphenyl)-2,3-dihydro-1-benzofuran-5-yl]-5,7-dihydroxy-8-(3-methylbut-2-enyl)-2,3-dihydrochromen-4-one | ||
SMILES | CC(=CCC1=C(C=C(C2=C1OC(CC2=O)C3=C(C=C4C(=C3)C(C(O4)C5=CC=C(C=C5)O)C6=CC(=CC(=C6)O)O)O)O)O)C | ||
Standard InChIKey | LERWTIGGXDMTNB-MXNXAHDOSA-N | ||
Standard InChI | InChI=1S/C34H30O9/c1-16(2)3-8-22-25(38)13-27(40)32-28(41)15-29(43-34(22)32)23-12-24-30(14-26(23)39)42-33(17-4-6-19(35)7-5-17)31(24)18-9-20(36)11-21(37)10-18/h3-7,9-14,29,31,33,35-40H,8,15H2,1-2H3/t29?,31-,33+/m1/s1 | ||
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
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About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
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Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. |
Description | Sophoraflavanone H is a natural product from Sophora moorcroftiana. |
Structure Identification | Chemical & Pharmaceutical Bulletin, 2008, 39(6):1568-72.Studies on the Constituents of Sophora Species. Part XXIV. Sophoraflavanones H, I and J, Flavonostilbenes from Sophora moorcroftiana.[Reference: WebLink]
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Sophoraflavanone H Dilution Calculator
Sophoraflavanone H Molarity Calculator
1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
1 mM | 1.7164 mL | 8.5822 mL | 17.1644 mL | 34.3289 mL | 42.9111 mL |
5 mM | 0.3433 mL | 1.7164 mL | 3.4329 mL | 6.8658 mL | 8.5822 mL |
10 mM | 0.1716 mL | 0.8582 mL | 1.7164 mL | 3.4329 mL | 4.2911 mL |
50 mM | 0.0343 mL | 0.1716 mL | 0.3433 mL | 0.6866 mL | 0.8582 mL |
100 mM | 0.0172 mL | 0.0858 mL | 0.1716 mL | 0.3433 mL | 0.4291 mL |
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. |
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Flavonoids as inhibitors of MRP1-like efflux activity in human erythrocytes. A structure-activity relationship study.[Pubmed:12812360]
Oncol Res. 2003;13(11):463-9.
The potency of flavonoids (isoflavones, flavones, and flavanones) to inhibit efflux of 2',7'-bis-(carboxypropyl)-5(6)-carboxyfluorescein (BCPCF) from human erythrocytes was investigated. Structure-activity relationship analysis showed that the strongest inhibitors were found among flavanones bearing a hydrophobic prenyl, geranyl, or lavandulyl group at position 8 (and hydroxyl groups at 5 and 7) in ring A. A prenyl group at position 5' or stilbene at positions 4'-5' in ring B further seemed to increase inhibitor potency. The most efficient flavanones, euchrestaflavanone A and Sophoraflavanone H, were approximately 20 times more efficient than genistein, and induced 50% inhibition of BCPCF efflux (IC50) at 3 microM (60 min, 37 degrees C). This is comparable to IC50 of benzbromarone (4 microM) and lower than IC50 of indomethacin (10 microM), both known MRP1 (ABCC1) inhibitors. It is suggested that BCPCF efflux is mainly due to MRP1 activity. Our results indicate that flavonoid molecular structure provides a promising base for development of potent MRP1 inhibitors.