Tanshinlactone

CAS# 105351-70-0

Tanshinlactone

2D Structure

Catalog No. BCN5867----Order now to get a substantial discount!

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Tanshinlactone: 5mg $748 In Stock
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Quality Control of Tanshinlactone

3D structure

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Tanshinlactone

Number of papers citing our products

Chemical Properties of Tanshinlactone

Cas No. 105351-70-0 SDF Download SDF
PubChem ID 5321617 Appearance Powder
Formula C17H12O3 M.Wt 264.3
Type of Compound Diterpenoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
SMILES CC1=CC=CC2=C1C=CC3=C2C(=O)OC4=C3OC=C4C
Standard InChIKey VDYMGLBSIBHGCP-UHFFFAOYSA-N
Standard InChI InChI=1S/C17H12O3/c1-9-4-3-5-12-11(9)6-7-13-14(12)17(18)20-15-10(2)8-19-16(13)15/h3-8H,1-2H3
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Tanshinlactone

The roots of Salvia miltiorrhiza

Biological Activity of Tanshinlactone

DescriptionStandard reference
In vitro

Two new abietane diterpenoids from Salvia yunnanensis.[Pubmed: 16450305]

Planta Med. 2006 Jan;72(1):84-6.


METHODS AND RESULTS:
Two new abietane diterpenoids, yunnannin A ( 1) and danshenol C ( 2), were isolated from SALVIA YUNNANENSIS together with ten known diterpenoids, danshenol A ( 3), przewalskin ( 4), tanshinone IIA, tanshinone I, crypotanshinone, 1,2-dihydrotanshinone, Tanshinlactone, 5,6-dehydrosugiol, 12-hydroxy-6,7-seco-8,11,3-abietatriene-6,7-dial and phytol. Their structures were established based on spectroscopic data, chemical reactions and comparison with literature data. Compounds 1 - 3 were tested for their antitumor activity in T-24, QGY, K562, Me180 and BIU87 cell lines.
CONCLUSIONS:
Compound 3 showed inhibited growth of K562 (IC 50 = 0.53 μg/mL), T-24 (IC 50 = 7.94 μg/mL), QGY (IC 50 = 4.65 μg/mL) and Me180 (IC 50 = 6.89 μg/mL) cell lines while compound 2 was inactive. Compound 1 showed moderate inhibitory activity on QGY (IC 50 = 16.75 μg/mL) and Me180 (IC 50 = 5.84 μg/mL) cells.

Tanshinlactone Dilution Calculator

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Tanshinlactone Molarity Calculator

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Preparing Stock Solutions of Tanshinlactone

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.7836 mL 18.9179 mL 37.8358 mL 75.6716 mL 94.5895 mL
5 mM 0.7567 mL 3.7836 mL 7.5672 mL 15.1343 mL 18.9179 mL
10 mM 0.3784 mL 1.8918 mL 3.7836 mL 7.5672 mL 9.4589 mL
50 mM 0.0757 mL 0.3784 mL 0.7567 mL 1.5134 mL 1.8918 mL
100 mM 0.0378 mL 0.1892 mL 0.3784 mL 0.7567 mL 0.9459 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Tanshinlactone

Two new abietane diterpenoids from Salvia yunnanensis.[Pubmed:16450305]

Planta Med. 2006 Jan;72(1):84-6.

Two new abietane diterpenoids, yunnannin A and danshenol C, were isolated from Salvia yunnanensis together with ten known diterpenoids, danshenol A, przewalskin, tanshinone IIA, tanshinone I, crypotanshinone, 1,2-dihydrotanshinone, Tanshinlactone, 5,6-dehydrosugiol, 12-hydroxy-6,7-seco-8,11,3-abietatriene-6,7-dial and phytol. Their structures were established based on spectroscopic data, chemical reactions and comparison with literature data. Compounds were tested for their antitumor activity in T-24, QGY, K562, Me180 and BIU87 cell lines. Compound showed inhibited growth of K562 (IC50=0.53 microg/mL), T-24 (IC50=7.94 microg/mL), QGY (IC50=4.65 microg/mL) and Me180 (IC50=6.89 microg/mL) cell lines while compound was inactive. Compound showed moderate inhibitory activity on QGY (IC50=16.75 microg/mL) and Me180 (IC50=5.84 microg/mL) cells.

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