Aloeresin D

CAS# 105317-67-7

Aloeresin D

Catalog No. BCN2850----Order now to get a substantial discount!

Product Name & Size Price Stock
Aloeresin D: 5mg $104 In Stock
Aloeresin D: 10mg Please Inquire In Stock
Aloeresin D: 20mg Please Inquire Please Inquire
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Quality Control of Aloeresin D

Number of papers citing our products

Chemical structure

Aloeresin D

3D structure

Chemical Properties of Aloeresin D

Cas No. 105317-67-7 SDF Download SDF
PubChem ID 14211225 Appearance Powder
Formula C29H32O11 M.Wt 556.56
Type of Compound Flavonoids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
Chemical Name [(2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-2-[2-[(2R)-2-hydroxypropyl]-7-methoxy-5-methyl-4-oxochromen-8-yl]oxan-3-yl] (E)-3-(4-hydroxyphenyl)prop-2-enoate
SMILES CC1=CC(=C(C2=C1C(=O)C=C(O2)CC(C)O)C3C(C(C(C(O3)CO)O)O)OC(=O)C=CC4=CC=C(C=C4)O)OC
Standard InChIKey OUGNWRCWQLUXHX-ACWXGELRSA-N
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Aloeresin D

The herbs of Aloe arborescens Mill.

Biological Activity of Aloeresin D

TargetsBACE | Beta Amyloid

Aloeresin D Dilution Calculator

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Aloeresin D Molarity Calculator

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Preparing Stock Solutions of Aloeresin D

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.7968 mL 8.9838 mL 17.9675 mL 35.935 mL 44.9188 mL
5 mM 0.3594 mL 1.7968 mL 3.5935 mL 7.187 mL 8.9838 mL
10 mM 0.1797 mL 0.8984 mL 1.7968 mL 3.5935 mL 4.4919 mL
50 mM 0.0359 mL 0.1797 mL 0.3594 mL 0.7187 mL 0.8984 mL
100 mM 0.018 mL 0.0898 mL 0.1797 mL 0.3594 mL 0.4492 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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References on Aloeresin D

BACE1 (beta-secretase) inhibitory chromone glycosides from Aloe vera and Aloe nobilis.[Pubmed:18543151]

Planta Med. 2008 Apr;74(5):540-5.

Four new chromone glycosides allo-Aloeresin D (2) , C-2'-decoumaroyl-aloeresin G (8), 2'-O-coumaroyl-(S)-aloesinol (9), 2'-O-[ P-methoxy-(E)-cinnamoyl]-(S)-aloesinol (10) and nine known chromone glycosides ( 1, 3 - 7, 11 - 13) were isolated from two Aloe spp. plants, A. vera and A. nobilis. Among them, 1 and 8 showed significant inhibitory activity against BACE1 (beta-secretase) with IC (50) values of 39.0 and 20.5 x 10 (-6) M, as well as inhibition of Abeta (1-42) production by 7.4 and 12.3 %, respectively, in B103 neuroblastoma cells at 30 ppm. The preliminary structure-activity relationships of ALOE chromone glucosides were also discussed.

Description

Aloeresin D is a chromone glycoside isolated from Aloe vera, inhibits β-Secretase (BACE1) activity, with an IC50 of 39 μM.

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