Vindoline

CAS# 2182-14-1

Vindoline

2D Structure

Catalog No. BCN4933----Order now to get a substantial discount!

Product Name & Size Price Stock
Vindoline: 5mg $6 In Stock
Vindoline: 10mg Please Inquire In Stock
Vindoline: 20mg Please Inquire Please Inquire
Vindoline: 50mg Please Inquire Please Inquire
Vindoline: 100mg Please Inquire Please Inquire
Vindoline: 200mg Please Inquire Please Inquire
Vindoline: 500mg Please Inquire Please Inquire
Vindoline: 1000mg Please Inquire Please Inquire

Quality Control of Vindoline

3D structure

Package In Stock

Vindoline

Number of papers citing our products

Chemical Properties of Vindoline

Cas No. 2182-14-1 SDF Download SDF
PubChem ID 11953805 Appearance Powder
Formula C25H32N2O6 M.Wt 456.5
Type of Compound Alkaloids Storage Desiccate at -20°C
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
SMILES CCC12C=CCN3C1C4(CC3)C(C(C2OC(=O)C)(C(=O)OC)O)N(C5=C4C=CC(=C5)OC)C
Standard InChIKey CXBGOBGJHGGWIE-MXXIQHGTSA-N
Standard InChI InChI=1S/C25H32N2O6/c1-6-23-10-7-12-27-13-11-24(19(23)27)17-9-8-16(31-4)14-18(17)26(3)20(24)25(30,22(29)32-5)21(23)33-15(2)28/h7-10,14,19-21,30H,6,11-13H2,1-5H3/t19-,20+,21+,23+,24+,25?/m0/s1
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Source of Vindoline

The herbs of Catharanthus roseus (L.) G. Don

Biological Activity of Vindoline

DescriptionVindoline is a chemical precursor to vinblastine and exhibits antimitotic activity by inhibiting microtubule assembly, it also has anti-ulcer activity. Vindoline can enhance the glucose-stimulated insulin secretion (GSIS) in MIN6 cells with the EC50 value of 50.2uM; it has relaxant effects in isolated rat renal arteries, it can dilate renal arteries in vitro through one or more pathways including inhibition of calcium entry,TEA+-sensitive potassium channel or protein kinase pathways in vascular smooth muscle cells.
TargetsAntifection | Calcium Channel | Potassium Channel
In vitro

Synthesis and glucose-stimulate insulin secretion (GSIS) evaluation of vindoline derivatives.[Pubmed: 28162858 ]

Bioorg Med Chem Lett. 2017 Mar 1;27(5):1316-1318.

It is demonstrated that natural product Vindoline can enhance the glucose-stimulated insulin secretion (GSIS) in MIN6 cells with the EC50 value of 50.2μM. In order to improve the activities, a series of Vindoline derivatives are synthesized and evaluated in MIN6 cells.
CONCLUSIONS:
Compounds 4, 8, 17 and 24 show about 4.5 times more effective stimulation insulin secretion ability (EC50: 10.4, 14.2, 11.0 and 12.7μM, respectively) than Vindoline.

Relaxant effect of vindoline in isolated rat renal arteries.[Reference: WebLink]

Chinese Pharmacological Bulletin, 2012, 28(8):1096 -100.

To explore the underlying relaxation mechanisms of Vindoline in isolated rat renal arteries.
METHODS AND RESULTS:
: Rings were quickly isolated and suspended in a Multi Myograph System and changes of isometric tension were recorded in the absence or presence of different receptor inhibitors or ion channel blockers. Vindoline produced a dose-dependent relaxation in rings with or without endothelia contracted by phenylephrine or KCl. Treatment with TEA + or Ro-34-0432 slightly blunt the relaxation induced by Vindoline, whereas gliclamide, BaCl 2 or Y-27632 failed to affect this relaxant effect. Vindoline reduced the contraction evoked by CaCl 2 in Ca-free 60 mmol·L -1 K + Kreb's solution, as well as in (-)-Bay K8644 in 15 mmol·L -1 K + solution. In addition, Vindoline caused the parallel relaxation in rings with or without endothelia.
CONCLUSIONS:
The current results suggest that Vindoline dilates renal arteries in vitro through one or more pathways including inhibition of calcium entry, TEA + sensitive potassium channel or protein kinase pathways in vascular smooth muscle cells.

In vivo

Vincamine and Vindoline from Catharanthus roseus linn. Protects the Gastric Mucosa of Gastric Ulcer in Rats[Reference: WebLink]

Pharmacologia, 2013, 4(2013):243-8.

Currently, natural products have been shown to present interesting biological and pharmacological activities and are used as chemotherapeutic agents. Plants have historically been used in treating cancer and are recognized for their ability to produce secondary metabolites. The current study was designed to evaluate the antiulcer activity of total extract as well as several fractions from Cantharanthus roseous Linn. (Family; Apocyanaceae) leaves. The bioassay guided chloroform fraction of the ethanol extract yielded two major compounds which have shown a promising antiulcer activity.
METHODS AND RESULTS:
C. roseus leaves were evaluated against Cold Restraint Ulcer (CRU), Aspirin (AS), Alcohol (AL) and Pyloric ligation (PL) induced gastric ulcer models in rats. Potential anti-ulcer activity was observed. Potential anti-ulcer activity was observed against CRU (75.18%), AS (50.00%), AL (65.00%) and PL (50.00%) induced ulcer models. The standard drug omeprazole (10 mg kg-1, p.o.) showed 77.34% protection against CRU, 57.08% against AS and 69.42% against PL induced ulcer model. Sucralfate, another standard drug (500 mg kg-1, p.o.) showed 62.72% protection in AL induced ulcer model. Ethanol extract of C. roseus leaves significantly reduced free acidity (17.78%), total acidity (8.05%) and up regulated mucin secretion by 25.11%, respectively. Phytochemical investigations of chloroform fraction yielded vincamine and Vindoline . Further, Fr-CHCl3 and its compounds vincamine and Vindoline significantly showing protection against CRU 81.08 and 81.20%, respectively, confirming their anti-ulcer activity.
METHODS AND RESULTS:
The anti-ulcerogenic activity of the chloroform fraction might be due to its anti-secretory activity. This study is the first of its kind to show significant anti-ulcer effect of C. roseus. Therefore, it could act as a potent therapeutic agent against peptic ulcer disease.

Protocol of Vindoline

Animal Research

Natural product vindoline stimulates insulin secretion and efficiently ameliorates glucose homeostasis in diabetic murine models.[Pubmed: 24012527]

J Ethnopharmacol. 2013 Oct 28;150(1):285-97.

To systematically investigate the potential anti-diabetic effects and the underlying anti-diabetic mechanisms of Vindoline, one of the alkaloids in Catharanthus roseus.
METHODS AND RESULTS:
The regulation of Vindoline against the glucose-stimulated insulin secretion (GSIS) was examined in insulinoma MIN6 cells and primary pancreatic islets. Insulin concentration was detected by Elisa assay. Diabetic models of db/db mice and type 2 diabetic rats induced by high-fat diet combining with streptozotocin (STZ/HFD-induced type 2 diabetic rats) were used to evaluate the anti-diabetic effect of Vindoline in vivo. Daily oral treatment with Vindoline (20mg/kg) to diabetic mice/rats for 4 weeks, body weight and blood glucose were determined every week, oral glucose tolerance test (OGTT) was performed after 4 weeks. Vindoline enhanced GSIS in both glucose- and dose-dependent manners (EC50 = 50 μM). It was determined that Vindoline acted as a Kv2.1 inhibitor able to reduce the voltage-dependent outward potassium currents finally enhancing insulin secretion. It protected β-cells from the cytokines-induced apoptosis following its inhibitory role in Kv2.1. Moreover, Vindoline (20mg/kg) treatment significantly improved glucose homeostasis in db/db mice and STZ/HFD-induced type 2 diabetic rats, as reflected by its functions in increasing plasma insulin concentration, protecting the pancreatic β-cells from damage, decreasing fasting blood glucose and glycated hemoglobin (HbA1c), improving OGTT and reducing plasma triglyceride (TG).
CONCLUSIONS:
Our findings suggested that Vindoline might contribute to the anti-diabetic effects of Catharanthus roseus, and this natural product may find its more applications in the improvement of β-cell dysfunction and further the potential treatment of type 2 diabetes.

Vindoline Dilution Calculator

Concentration (start)
x
Volume (start)
=
Concentration (final)
x
Volume (final)
 
 
 
C1
V1
C2
V2

calculate

Vindoline Molarity Calculator

Mass
=
Concentration
x
Volume
x
MW*
 
 
 
g/mol

calculate

Preparing Stock Solutions of Vindoline

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.1906 mL 10.9529 mL 21.9058 mL 43.8116 mL 54.7645 mL
5 mM 0.4381 mL 2.1906 mL 4.3812 mL 8.7623 mL 10.9529 mL
10 mM 0.2191 mL 1.0953 mL 2.1906 mL 4.3812 mL 5.4765 mL
50 mM 0.0438 mL 0.2191 mL 0.4381 mL 0.8762 mL 1.0953 mL
100 mM 0.0219 mL 0.1095 mL 0.2191 mL 0.4381 mL 0.5476 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Organizitions Citing Our Products recently

 
 
 

Calcutta University

University of Minnesota

University of Maryland School of Medicine

University of Illinois at Chicago

The Ohio State University

University of Zurich

Harvard University

Colorado State University

Auburn University

Yale University

Worcester Polytechnic Institute

Washington State University

Stanford University

University of Leipzig

Universidade da Beira Interior

The Institute of Cancer Research

Heidelberg University

University of Amsterdam

University of Auckland
TsingHua University
TsingHua University
The University of Michigan
The University of Michigan
Miami University
Miami University
DRURY University
DRURY University
Jilin University
Jilin University
Fudan University
Fudan University
Wuhan University
Wuhan University
Sun Yat-sen University
Sun Yat-sen University
Universite de Paris
Universite de Paris
Deemed University
Deemed University
Auckland University
Auckland University
The University of Tokyo
The University of Tokyo
Korea University
Korea University
Featured Products
New Products
 

References on Vindoline

Synthesis and glucose-stimulate insulin secretion (GSIS) evaluation of vindoline derivatives.[Pubmed:28162858]

Bioorg Med Chem Lett. 2017 Mar 1;27(5):1316-1318.

It is demonstrated that natural product Vindoline can enhance the glucose-stimulated insulin secretion (GSIS) in MIN6 cells with the EC50 value of 50.2muM. In order to improve the activities, a series of Vindoline derivatives are synthesized and evaluated in MIN6 cells. Compounds 4, 8, 17 and 24 show about 4.5 times more effective stimulation insulin secretion ability (EC50: 10.4, 14.2, 11.0 and 12.7muM, respectively) than Vindoline.

Natural product vindoline stimulates insulin secretion and efficiently ameliorates glucose homeostasis in diabetic murine models.[Pubmed:24012527]

J Ethnopharmacol. 2013 Oct 28;150(1):285-97.

ETHNOPHARMACOLOGICAL RELEVANCE: Catharanthus roseus (L). Don (Catharanthus roseus) is a traditional anti-diabetic herb widely used in many countries, and the alkaloids of Catharanthus roseus are considered to possess hypoglycemic ability. AIM OF THE STUDY: To systematically investigate the potential anti-diabetic effects and the underlying anti-diabetic mechanisms of Vindoline, one of the alkaloids in Catharanthus roseus. MATERIALS AND METHODS: The regulation of Vindoline against the glucose-stimulated insulin secretion (GSIS) was examined in insulinoma MIN6 cells and primary pancreatic islets. Insulin concentration was detected by Elisa assay. Diabetic models of db/db mice and type 2 diabetic rats induced by high-fat diet combining with streptozotocin (STZ/HFD-induced type 2 diabetic rats) were used to evaluate the anti-diabetic effect of Vindoline in vivo. Daily oral treatment with Vindoline (20mg/kg) to diabetic mice/rats for 4 weeks, body weight and blood glucose were determined every week, oral glucose tolerance test (OGTT) was performed after 4 weeks. RESULTS: Vindoline enhanced GSIS in both glucose- and dose-dependent manners (EC50 = 50 muM). It was determined that Vindoline acted as a Kv2.1 inhibitor able to reduce the voltage-dependent outward potassium currents finally enhancing insulin secretion. It protected beta-cells from the cytokines-induced apoptosis following its inhibitory role in Kv2.1. Moreover, Vindoline (20mg/kg) treatment significantly improved glucose homeostasis in db/db mice and STZ/HFD-induced type 2 diabetic rats, as reflected by its functions in increasing plasma insulin concentration, protecting the pancreatic beta-cells from damage, decreasing fasting blood glucose and glycated hemoglobin (HbA1c), improving OGTT and reducing plasma triglyceride (TG). CONCLUSION: Our findings suggested that Vindoline might contribute to the anti-diabetic effects of Catharanthus roseus, and this natural product may find its more applications in the improvement of beta-cell dysfunction and further the potential treatment of type 2 diabetes.

Description

Vindoline, a vinca alkaloid extracted from the leaves of Catharanthus roseus, weakly inhibits tubulin self-assembly.

Keywords:

Vindoline,2182-14-1,Natural Products, buy Vindoline , Vindoline supplier , purchase Vindoline , Vindoline cost , Vindoline manufacturer , order Vindoline , high purity Vindoline

Online Inquiry for:

      Fill out the information below

      • Size:Qty: - +

      * Required Fields

                                      Result: