p53
p53 (TP53) is a transcription factor whose protein levels and post-translational modification state alter in response to cellular stress (e.g. hypoxia, DNA and spindle damage). Activation of p53 occurs by several mechanisms including phosphorylation by ATM, ATR, Chk1 and MAPKs.
Products for p53
- Cat.No. Product Name Information/Activity
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BCC2241
Pifithrin-α (PFTα)
Pifithrin-α hydrobromide is a p53 inhibitor which blocks its transcriptional activity and prevents cells from apoptosis. Pifithrin-α hydrobromide is also an aryl hydrocarbon receptor (AhR) agonist.
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BCC2407
Cyclic Pifithrin-α hydrobromide
Pifithrin-β hydrobromide (PFT β hydrobromide) is a potent p53 inhibitor with an IC50 of 23 μM.
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BCC2412
Pifithrin-μ
Pifithrin-μ is an inhibitor of p53 and HSP70, with antitumor and neuroprotective activity.
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BCC2408
HLI 373
Hdm2 inhibitor; activates p53-dependent transcription
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BCC2410
NSC 146109 hydrochloride
NSC 146109 hydrochloride is a small-molecule p53 activator that target MDMX and could be of value in treating breast cancer. NSC 146109 hydrochloride is a pseudourea derivative, promotes breast cancer cells to undergo apoptosis through activating p53 and inducing expression of proapoptotic genes[1].
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BCC2242
NSC 319726
NSC319726 (ZMC1) is a mutant p53R175 reactivator; inhibits growth of fibroblasts expressing the p53R175 mutation (IC50 = 8 nM); shows no inhibition for p53 wild-type cells.
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BCC2255
NSC 66811
MDM2 inhibitor. Disrupts MDM2-p53 interaction
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BCC2238
RITA (NSC 652287)
RITA is an inhibitor of p53-HDM-2 interaction, binds to p53dN, with a Kd of 1.5 nM, and also induces DNA-DNA cross-links.
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BCC2416
SJ 172550
SJ-172550 is a small molecule inhibitor of MDMX; competes for the wild type p53 peptide binding to MDMX with an EC50 of 5 μM.
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BCC2239
Tenovin-1
Tenovin-1 is an inhibitor of sirtuin 1 and sirtuin 2, an activator of p53 and may have potential in the management of cancer.
