Arrhythmia Research
An arrhythmia (also known as cardiac dysrhythmia) is defined as an irregular heartbeat, and results from abnormal electrical activity in the heart. There are various different types of arrhythmia, often resulting in a heartbeat that is too fast (tachycardia) or too slow (bradycardia). Atrial and ventricular fibrillation, which are the most common cardiac arrhythmias, account for 10-20% of all deaths among adults in the Western world. The incidence of atrial fibrillation increases with age; it not only affects cardiac function, but also increases the risk of stroke and may worsen heart failure.
Arrhythmia Research Products Targets
- Voltage-gated Sodium (NaV) Channel (30)
- Voltage-gated Potassium (KV) Channel (38)
- Voltage-gated Calcium Channel (CaV) (38)
- Epithelial Sodium Channel (3)
- STIM-Orai Channel (4)
- Ryanodine Receptor (6)
- IP3 Receptor (2)
- Acid-Sensing Ion Channel (3)
- Calcium-Activated Potassium (KCa) Channel (19)
- Inward Rectifier Potassium (Kir) Channel (21)
- HCN Channel (4)
- Adrenergic β3 Receptor (12)
- Adrenergic β2 Receptor (6)
- Adrenergic β1 Receptor (7)
Products for Arrhythmia Research - Page 6
- Cat.No. Product Name Information/Activity
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BCC1083
Cilnidipine
Cilnidipine(FRC8653) is a dual L- and N-type calcium channel blocker and displays antihypertensive, sympatholytic and neuroprotective activity.
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BCC5700
ω-Conotoxin GVIA
106375-28-4
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BCC5699
ω-Conotoxin MVIIC
147794-23-8
-
BCC4901
Diltiazem HCl
Diltiazem hydrochloride is a Ca2+ influx inhibitor (slow channel blocker or calcium antagonist).
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BCC7767
Efonidipine hydrochloride monoethanolate
Efonidipine hydrochloride monoethanolate (NZ-105 hydrochloride monoethanolate) is a dual T-type and L-type calcium channel blocker (CCB).
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BCC4402
Felodipine
Felodipine is a long-acting 1,4-dihydropyridine calcium channel blocker.
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BCC4398
Flunarizine 2HCl
Flunarizine is a selective calcium entry blocker.
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BCC8041
Huwentoxin XVI
Potent and reversible N-type Ca<sup>2+</sup> channel blocker
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BCC3797
Isradipine (Dynacirc)
Isradipine(Dynacirc) is a calcium channel blocker with an IC50 of 34±8 μM.
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BCC7561
L-651,582
Carboxyamidotriazole (L-651582) is a cytostatic inhibitor of nonvoltage-operated calcium channels and calcium channel-mediated signaling pathways. Carboxyamidotriazole shows anti-tumor, anti-inflammatory and antiangiogenic effects.


