Arrhythmia Research
An arrhythmia (also known as cardiac dysrhythmia) is defined as an irregular heartbeat, and results from abnormal electrical activity in the heart. There are various different types of arrhythmia, often resulting in a heartbeat that is too fast (tachycardia) or too slow (bradycardia). Atrial and ventricular fibrillation, which are the most common cardiac arrhythmias, account for 10-20% of all deaths among adults in the Western world. The incidence of atrial fibrillation increases with age; it not only affects cardiac function, but also increases the risk of stroke and may worsen heart failure.
Arrhythmia Research Products Targets
- Voltage-gated Sodium (NaV) Channel (30)
- Voltage-gated Potassium (KV) Channel (38)
- Voltage-gated Calcium Channel (CaV) (38)
- Epithelial Sodium Channel (3)
- STIM-Orai Channel (4)
- Ryanodine Receptor (6)
- IP3 Receptor (2)
- Acid-Sensing Ion Channel (3)
- Calcium-Activated Potassium (KCa) Channel (19)
- Inward Rectifier Potassium (Kir) Channel (21)
- HCN Channel (4)
- Adrenergic β3 Receptor (12)
- Adrenergic β2 Receptor (6)
- Adrenergic β1 Receptor (7)
Products for Arrhythmia Research - Page 15
- Cat.No. Product Name Information/Activity
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BCC1683
KN-93
CaM kinase II inhibitor; also K<sup>+</sup> channel blocker (K<sub>V</sub>),KN-93 is a novel membrane-permeant synthetic inhibitor of purified neuronal <b>CaMK-II</b>, with K<sub>i</sub> of 370 nM.
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BCC7231
Linopirdine dihydrochloride
113168-57-3
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BCC7709
Margatoxin
Margatoxin, an alpha-KTx scorpion toxin, is a high affinity inhibitor of Kv1.3 (Kd=11.7 pM). Margatoxin inhibits the Kv1.2 (Kd=6.4 pM) and Kv1.1 (Kd=4.2 nM). Margatoxin, a 39 amino-acid-long peptide, is isolated from the venom of the scorpion Centruroides margaritatus and widely used in ion channel research.
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BCC7927
Psora 4
Potent K<sub>V</sub>1.3 channel blocker
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BCC6044
RuBi-4AP
851956-02-0
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BCC5990
ShK-Dap22
220384-25-8
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BCC7554
Tetraethylammonium chloride
Non-selective K<sup>+</sup> channel blocker
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BCC7784
UK 78282 hydrochloride
136647-02-4
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BCC7232
XE 991 dihydrochloride
XE 991 dihydrochloride, a Kv7 (KCNQ) channels blocker, potently inhibits Kv7.1 (KCNQ1), Kv7.2 (KCNQ2), Kv7.2 + Kv7.3 (KCNQ3) channel, and M-current with IC50s of 0.75 µM, 0.71 µM, 0.6 μM, and 0.98 µM, respectively.
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BCC4907
Fluticasone propionate
Fluticasone propionate is a high affinity, selective GR (glucocorticoid receptor) agonist which is derived from fluticasone used to treat asthma and allergic rhinitis.


