Arrhythmia Research

An arrhythmia (also known as cardiac dysrhythmia) is defined as an irregular heartbeat, and results from abnormal electrical activity in the heart. There are various different types of arrhythmia, often resulting in a heartbeat that is too fast (tachycardia) or too slow (bradycardia). Atrial and ventricular fibrillation, which are the most common cardiac arrhythmias, account for 10-20% of all deaths among adults in the Western world. The incidence of atrial fibrillation increases with age; it not only affects cardiac function, but also increases the risk of stroke and may worsen heart failure.

Arrhythmia Research Products Targets

Products for Arrhythmia Research - Page 14

  1. Cat.No. Product Name Information/Activity
  2. BCC7691 Astemizole Astemizole (R 43512), a second-generation antihistamine drug to diminish allergic symptoms with a long duration of action, is a histamine H1-receptor antagonist, with an IC50 of 4 nM. Astemizole also shows potent hERG K+ channel blocking activity with an IC50 of 0.9 nM. Astemizole has antipruritic effects. Astemizole chemical structure
  3. BCC5456 BAPTA-AM BAPTA-AM is a well-known membrane permeable Ca2+ chelator. BAPTA-AM inhibits hERG channels, hKv1.3 and hKv1.5 channels in HEK 293 cells with IC50s of 1.3 μM, 1.45 μM and 1.23 μM, respectively. BAPTA-AM chemical structure
  4. BCC7055 Chromanol 293B 163163-23-3 Chromanol 293B chemical structure
  5. BCC7080 (-)-[3R,4S]-Chromanol 293B 163163-24-4 (-)-[3R,4S]-Chromanol 293B chemical structure
  6. BCC7048 CP 339818 hydrochloride 478341-55-8 CP 339818 hydrochloride chemical structure
  7. BCC3770 Dofetilide Dofetilide(Tikosyn) is a class III antiarrhythmic agent. Dofetilide chemical structure
  8. BCC7398 DPO-1 43077-30-1 DPO-1 chemical structure
  9. BCC7182 E-4031 dihydrochloride E-4031 is a class III antiarrhythmic agent which selectively blocks hERG potassium channel. E-4031 dihydrochloride chemical structure
  10. BCC7806 JNJ 303 JNJ 303 is a potent IKs blocker with an IC50 value of 64 nM. JNJ 303 does not have any effects on other cardiac channels at concentrations of 3.3 μM for INa, Ica, Ito, and IKr. JNJ 303 induces QT-prolongations and causes unprovoked torsades de pointes (TdP). JNJ 303 chemical structure
  11. BCC1682 KN-92 phosphate KN-92 phosphate is an inactive derivative of KN-93. KN-92 phosphate chemical structure

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