Depression Research

Major depressive disorder, often referred to as major depression, is a heterogenous condition with complex and diverse neurobiological etiologies. Depression is characterized by a triad of symptoms: low or depressed mood, anhedonia and low energy or fatigue. Approximately 15% of the population in developed countries has been affected by depression in their lifetime and the chance of developing depression is twice as high in women. 40-50% of depressive causes are inheritable (genes as yet unidentified) and the remaining 50-60% of causes are caused by environmental stressors.

Depression Research Products Targets

Products for Depression Research - Page 47

  1. Cat.No. Product Name Information/Activity
  2. BCC6154 VU 0285683 327056-22-4 VU 0285683 chemical structure
  3. BCC4595 VU 0357121 VU0357121 is a novel positive and highly selective allosteric modulator (PAM) of mGlu5R with EC50 of 33 nM. VU 0357121 chemical structure
  4. BCC6141 VU 0360172 hydrochloride 1309976-62-2 VU 0360172 hydrochloride chemical structure
  5. BCC6159 VU 0360223 1274859-33-4 VU 0360223 chemical structure
  6. BCC7649 VU 1545 890764-63-3 VU 1545 chemical structure
  7. BCC7936 VU 29 890764-36-0 VU 29 chemical structure
  8. BCC6969 (2R,4R)-APDC (2R,4R)-APDC is a selective group II metabotropic glutamate receptors (mGluRs) agonist. (2R,4R)-APDC has anticonvulsant and neuroprotective effects. (2R,4R)-APDC chemical structure
  9. BCC6609 L-CCG-l 117857-93-9 L-CCG-l chemical structure
  10. BCC5691 DCG IV DCG-IV is a potent agonist of group II mGluRs with EC50s of 0.35 and 0.09 μM for mGlu2R and mGlu3R, reapectively. DCG-IV is also a competitive antagonist at group I (IC50: mGlu1/5R=389/630 μM) and III receptors (IC50: mGlu4/6/7/8R= 22.5/39.6/40.1/32 μM). DCG-IV has anticonvulsive and neuroprotective effects. DCG IV chemical structure
  11. BCC7614 LY 354740 Eglumegad (LY354740) is a highly potent and selective group II (mGlu2/3) receptor agonist with IC50s of 5 and 24 nM on transfected human mGlu2 and mGlu3 receptors, respectively. LY 354740 chemical structure

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