Depression Research

Major depressive disorder, often referred to as major depression, is a heterogenous condition with complex and diverse neurobiological etiologies. Depression is characterized by a triad of symptoms: low or depressed mood, anhedonia and low energy or fatigue. Approximately 15% of the population in developed countries has been affected by depression in their lifetime and the chance of developing depression is twice as high in women. 40-50% of depressive causes are inheritable (genes as yet unidentified) and the remaining 50-60% of causes are caused by environmental stressors.

Depression Research Products Targets

Products for Depression Research - Page 60

  1. Cat.No. Product Name Information/Activity
  2. BCC7442 WAY 213613 WAY-213613 is a potent, selective nonsubstrate reuptake inhibitor of GLT-1/EAAT2 with IC50 of 85 nM EAAT2. It displays 59- and 44-fold selectivity over EAAT1 and EAAT3 (IC50s are 5 and 3.8 μM, respectively). WAY-213613 shows no activity at ionotropic and metabotropic glutamate receptors. It is a potential tool for the elucidation of EAAT2 function. WAY 213613 chemical structure
  3. BCC7168 ALX 5407 hydrochloride Selective non-transportable GlyT1 inhibitor ALX 5407 hydrochloride chemical structure
  4. BCC7069 N-Arachidonylglycine 179113-91-8 N-Arachidonylglycine chemical structure
  5. BCC7677 LY 2365109 hydrochloride 868265-28-5 LY 2365109 hydrochloride chemical structure
  6. BCC7845 Org 24598 lithium salt 722456-08-8 Org 24598 lithium salt chemical structure
  7. BCC6288 Org 25543 hydrochloride Potent and selective GlyT2 inhibitor Org 25543 hydrochloride chemical structure
  8. BCN2744 Sarcosine Sarcosine is a glycine transporter type 1 (GlyT) inhibitor and an N-methyl-D-aspartate (NMDA) receptor co-agonist at the glycine binding site. Sarcosine chemical structure
  9. BCC2291 Cilostazol Cilostazol (OPC 13013) is a potent and selective inhibitor of phosphodiesterase (PDE) 3A, the isoform of PDE 3 in the cardiovascular system, with an IC50 of 0.2 μM. Cilostazol chemical structure
  10. BCC6271 Decynium 22 977-96-8 Decynium 22 chemical structure
  11. BCC6660 Dilazep dihydrochloride Dilazep dihydrochloride is an inhibitor of adenosine uptake. Dilazep dihydrochloride has cerebral and coronary vasodilating action through enhancement of effect of adenosine. Dilazep dihydrochloride also inhibits the ischemic damage, platelet aggregation, and membrane transport of nucleosides. Dilazep dihydrochloride chemical structure

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