Arthritis Research

Arthritis is an inflammatory disease of the joints, including the synovium, cartilage, bone, and supporting tissues. It is the leading cause of disability in the US and there are over 100 different types of the disease. The most common types of arthritis are osteoarthritis, rheumatoid arthritis and gout.

Arthritis Research Products Targets

Products for Arthritis Research - Page 18

Cat.No. Product Name Information/Activity
BCC1636 Hydroxyfasudil hydrochloride Hydroxyfasudil hydrochloride is a ROCK inhibitor, with IC50s of 0.73 and 0.72 μM for ROCK1 and ROCK2, respectively.
BCC6116 SB 772077B dihydrochloride SB-772077B dihydrochloride is an aminofurazan-based Rho kinase (ROCK) inhibitor with IC50s of 5.6 nM and 6 nM toward ROCK1 and ROCK2, respevtively.
BCC4302 SR-3677 SR-3677 is a potent and selective ROCK-II inhibitor with an IC50 of ~3 nM.
BCC1905 ROCK inhibitor ROCK-IN-2 (Azaindole 1; TC-S 7001) is an orally active and ATP-competitive ROCK inhibitor with IC50s of 0.6 and 1.1 nM for human ROCK-1 and ROCK-2, respectively.
BCC6689 L-NIO dihydrochloride L-NIO dihydrochloride is a potent, non-selective and NADPH-dependent nitric oxide synthase (NOS) inhibitor, with Kis of 1.7, 3.9, 3.9 μM for neuronal (nNOS), endothelial (eNOS), and inducible (iNOS), respectively. L-NIO dihydrochloride induces a consistentfocal ischemic infarctin rats.
BCC6795 Aminoguanidine hydrochloride Aminoguanidine hydrochloride is a diamine oxidase and NO synthase inhibitor, reduces levels of advanced glycation end products (AGEs) through interacting with 3-deoxyglucosone, is an investigational drug for the treatment of diabetic nephropathy.
BCC6823 AMT hydrochloride 21463-31-0
BCC6092 AR-C 102222 253771-21-0
BCC7506 BYK 191023 dihydrochloride Potent and selective inhibitor of iNOS
BCC6824 EIT hydrobromide 1071-37-0