Chemokine Receptors
Chemokine receptors are cytokine receptors found on the surface of certain cells that interact with a type of cytokine called a chemokine. There have been 20 distinct chemokine receptors discovered in humans. Each has a 7-transmembrane (7TM) structure and couples to G-protein for signal transduction within a cell, making them members of a large protein family of G protein-coupled receptors. Following interaction with their specific chemokine ligands, chemokine receptors trigger a flux in intracellular calcium (Ca2+) ions (calcium signaling). This causes cell responses, including the onset of a process known as chemotaxis that traffics the cell to a desired location within the organism. Chemokine receptors are divided into different families, CXC chemokine receptors, CC chemokine receptors, CX3C chemokine receptors and XC chemokine receptors that correspond to the 4 distinct subfamilies of chemokines they bind. Four families of chemokine receptors differ in spacing of cysteine residues near N-terminal of the receptor.
Products for Chemokine Receptors
- Cat.No. Product Name Information
- BCC5909 DAPTAChemokine receptor 5 (CCR5) antagonist
- BCC5936 SB 265610Potent CXCR2 antagonist
- BCC5940 BX 513 hydrochlorideSelective CCR1 antagonist
- BCC6029 BX 471Potent, selective CCR1 antagonist
- BCC6047 C 021 dihydrochloridePotent CCR4 antagonist
- BCC6056 SB 328437Potent and selective CCR3 antagonist
- BCC6057 Teijin compound 1Potent CCR2b antagonist
- BCC6129 SB 297006Potent and selective CCR3 antagonist
- BCC6234 IT1t dihydrochloridePotent CXCR4 antagonist
- BCC6366 CTCE 9908CXCR4 antagonist; induces mitotic catastrophe in ovarian cancer cells
- BCC7260 RS 102895 hydrochlorideCCR2b chemokine receptor antagonist
- BCC7413 ZK 756326Selective, non-peptide CCR8 agonist
- BCC7422 J 113863Potent CCR1 chemokine receptor antagonist
- BCC7572 BMS CCR2 22High affinity, potent CCR2 antagonist
- BCC7910 TC 14012CXCR4 antagonist; ACKR3 (CXCR7) agonist
- BCC7917 FC 131CXCR4 antagonist