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IT1t dihydrochloride

CXCR4 antagonist, potent CAS# 1092776-63-0

IT1t dihydrochloride

Catalog No. BCC6234----Order now to get a substantial discount!

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IT1t dihydrochloride: 5mg $104 In Stock
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Quality Control of IT1t dihydrochloride

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Chemical structure

IT1t dihydrochloride

3D structure

Chemical Properties of IT1t dihydrochloride

Cas No. 1092776-63-0 SDF Download SDF
PubChem ID 25178351 Appearance Powder
Formula C21H36Cl2N4S2 M.Wt 479.57
Type of Compound N/A Storage Desiccate at -20°C
Solubility DMSO : ≥ 30 mg/mL (62.56 mM)
*"≥" means soluble, but saturation unknown.
Chemical Name (6,6-dimethyl-5H-imidazo[2,1-b][1,3]thiazol-3-yl)methyl N,N'-dicyclohexylcarbamimidothioate;dihydrochloride
SMILES CC1(CN2C(=CSC2=N1)CSC(=NC3CCCCC3)NC4CCCCC4)C.Cl.Cl
Standard InChIKey HFXJOXOIINQOEB-UHFFFAOYSA-N
Standard InChI InChI=1S/C21H34N4S2.2ClH/c1-21(2)15-25-18(14-27-20(25)24-21)13-26-19(22-16-9-5-3-6-10-16)23-17-11-7-4-8-12-17;;/h14,16-17H,3-13,15H2,1-2H3,(H,22,23);2*1H
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months.
Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it.
About Packaging 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial.
2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial.
3. Try to avoid loss or contamination during the experiment.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request.

Biological Activity of IT1t dihydrochloride

DescriptionPotent CXCR4 antagonist (IC50 = 1.1 nM in calcium mobilization assays). Orally available. Blocks interaction with the HIV envelope protein, gp120 (IC50 = 7 nM, inhibition of X4-tropic HIV-1IIIB attachment).

IT1t dihydrochloride Dilution Calculator

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IT1t dihydrochloride Molarity Calculator

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Preparing Stock Solutions of IT1t dihydrochloride

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.0852 mL 10.426 mL 20.852 mL 41.704 mL 52.13 mL
5 mM 0.417 mL 2.0852 mL 4.1704 mL 8.3408 mL 10.426 mL
10 mM 0.2085 mL 1.0426 mL 2.0852 mL 4.1704 mL 5.213 mL
50 mM 0.0417 mL 0.2085 mL 0.417 mL 0.8341 mL 1.0426 mL
100 mM 0.0209 mL 0.1043 mL 0.2085 mL 0.417 mL 0.5213 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

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Background on IT1t dihydrochloride

IT1t dihydrochloride is a potent antagonist of CXCR4 with IC50 value of 8.0 nM [1].

C-X-C chemokine receptor type 4 (CXCR4) is an α-chemokine receptor for chemokine CXCL12. CXCR4 functions as a coreceptor for human immunodeficiency virus (HIV) envelope protein gp-120 and mediates infection of T-cells by HIV [1].

IT1t dihydrochloride is a potent CXCR4 antagonist. In binding assays, IT1t exhibited IC50 values of 8.0 and 11.0 nM for human and rat CXCR4, respectively. In Ca2+ mobilization assays, IT1t exhibited IC50 value of 1.1 nM. In the HIV attachment assay, IT1t inhibited HIV attachment with IC50 and IC90 values of 7 and 100 nM, respectively and inhibited both CXCR4/CXCL12 and CXCR4/gp120 interactions. IT1t exhibited 32% oral bioavailability.

References:
[1].  Thoma G, Streiff MB, Kovarik J, et al. Orally bioavailable isothioureas block function of the chemokine receptor CXCR4 in vitro and in vivo. J Med Chem, 2008, 51(24): 7915-7920.

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References on IT1t dihydrochloride

Orally bioavailable isothioureas block function of the chemokine receptor CXCR4 in vitro and in vivo.[Pubmed:19053768]

J Med Chem. 2008 Dec 25;51(24):7915-20.

The interaction of the chemokine receptor CXCR4 with its ligand CXCL12 is involved in many biological processes such as hematopoesis, migration of immune cells, as well as in cancer metastasis. CXCR4 also mediates the infection of T-cells with X4-tropic HIV functioning as a coreceptor for the viral envelope protein gp120. Here, we describe highly potent, selective CXCR4 inhibitors that block CXCR4/CXCL12 interactions in vitro and in vivo as well as the infection of target cells by X4-tropic HIV.

Description

IT1t dihydrochloride is a potent CXCR4 antagonist; inhibits CXCL12/CXCR4 interaction with an IC50 of 2.1 nM.

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