Products with Antagonists bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN6166 | alpha-Yohimbine |
| 1. Alpha-Yohimbine is strong selective 2-adrenoceptor antagonist. 2. Alpha-Yohimbine possess aphrodisiac effect. 3. Alpha-Yohimbine is a 5-HT1A receptor agonist. | |
| BCN6268 | Yohimbine Hydrochloride |
| Yohimbine hydrochloride is an alpha 2-adrenoreceptor antagonist, blocking the pre- and postsynaptic alpha-2 adrenoreceptors and causing an increased release of noradrenaline and dopamine.It is an antagonist to xylazine hydrochloride-ketamine hydrochloride immobilization of white-tailed deer. Yohimbine has been used as a mydriatic and in the treatment of impotence. It is also alleged to be an aphrodisiac. | |
| BCN6310 | Tetrahydropalmatine |
| Tetrahydropalmatine, a plant alkaloid used as an ingredient in dietary supplement products, is a potent and selective D1 receptor antagonist. Tetrahydropalmatine shows a promyogenic effect by upregulation of p38MAPK, Akt resulting in enhanced MyoD activation, it can effectively protect endothelial cells against γ-irradiation injury. Tetrahydropalmatine has a potential as a therapeutic candidate to prevent fibrosis and improve muscle regeneration and repair and applied to the prevention of endothelial cell dysfunctions associated with ionizing irradiation-induced lung injury. | |
| BCN6408 | Futoenone |
| 1. Futoenone and a series of its derivatives have shown inhibitory activities against matrix metalloproteinases, the molecular modelings of these compounds indicate the preferred binding of the P2′ site of the enzymes. 2. Neolignan derivative compounds of the 2,4-diaryl-1,3-dithiolane and futoenone variety exhibit both platelet activating factor receptor(PAF)and 5-lipoxygenase antagonist activity. | |
| BCN6573 | 6-Deoxyjacareubin |
| 1. 6-Deoxyjacareubin, 1,5-dihydroxyxanthone, and 5-hydroxy-1-methoxyxanthoneis are antifungal against Cladosporium cucumerinum, while they show differing degrees of inhibition of monoamine oxidase A and B. 2. 6-Deoxyjacareubin shows strong platelet activating factor (PAF) receptor binding inhibitory effects using rabbit platelets with IC50 values of 29.0 microM, suggests that xanthones can represent a new class of natural PAF receptor antagonists. 3. 6-Deoxyjacareubin possesses significant antioxidant activities. 4. 6-Deoxyjacareubin exhibits the cytotoxic activities against HL-60, SMMC-7721, A-549, MCF-7, and SW-480 cell lines. | |
