Products with Antagonists bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN3949 | Coumestrol |
| 1. Coumestrol suppresses the accumulation of HIF-1α via suppression of SPHK1 pathway in hypoxic PC-3 cells. 2. Coumestrol is a novel inducer of mitochondrial biogenesis through the activation of Sirt1. 3. Coumestrol can function by inhibiting oncogenic disease, at least in part, through CKII inhibition-mediated cellular senescence. 4. Coumestrol treatment is effective in preventing neuronal loss in all times of administration as well as able to rescue the Na+, K+ -ATPase activity, suggesting its potential benefits for either prevention or therapeutics use against cerebral ischemia in males. | |
| BCN4376 | Stigmasterol |
| Stigmasterol is used as a precursor in the manufacture of synthetic progesterone, it is an antagonist of the bile acid nuclear receptor FXR, which has anti-inflammatory, thyroid inhibitory, cholesterol-lowering, antiperoxidative and hypoglycemic effects; it has indicated that stigmasterol may be useful in prevention of certain cancers, including ovarian, prostate, breast, and colon cancers. Stigmasterol inhibits the NF-kappaB pathway. | |
| BCN4815 | (-)-Variabilin |
| 1. Variabilin, a novel inhibitor of human platelet aggregation, it is a potent RGD (Arg-Gly-Asp)-containing antagonist of the fibrinogen receptor glycoprotein IIb-IIIa (GPIIb-IIIa; αIIbβ3) and the vitronectin receptor αvβ3. 2. Variabilin is an inhibitor of human secretory and cytosolic phospholipase A2 (PLA2) activities that controls eicosanoid production in vitro and in vivo, inhibits neutrophil degranulation and superoxide generation in vitro and shows anti-inflammatory activity after topical or p.o. administration to mice. 3. Variabilin is an antimicrobial furanosesterterpene. 4. Variabilin is an important chemotaxonomic marker for the family Irciniidae. | |
| BCN4925 | Agrimonolide |
| 1. Agrimonolide exerts anti-inflammatory activity, at least in part, via suppressing LPS-induced activation of JAK-STATs and p38 MAPKs signaling pathway. 2. Agrimonolide is a potential α1 adrenergic receptor antagonist . 3. Agrimonolide and desmethylagrimonolide can effectively increase insulin-mediated glycogen level in heptocytes, they may play an important role in regulating glucose metabolism in insulin-resistance HepG2 cells and could be developed as a promising natural material for diabetes prevention and treatment. | |
| BCN5022 | Fargesin |
| Fargesin has anti-inflammatory, anti-cancer, antihypertensive , and anti-bone-resorbing effects, it is widely used in the treatment of managing rhinitis, inflammation, histamine, sinusitis, and headache. Fargesin improves lipid and glucose metabolism in 3T3-L1 adipocytes and high-fat diet-induced obese mice by activating Akt and AMPK in WAT. It as a potential β1 adrenergic receptor antagonist protects the hearts against ischemia/reperfusion injury in rats via attenuating oxidative stress and apoptosis. | |
