Products with Antagonists bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN1665 | Marmin |
| 1. Marmin can inhibit contraction of the guinea-pig tracheal smooth muscle, especially by interfering histamine receptor, inhibiting the histamine release from mast, inhibiting intracellular Ca2+ release from the intracellular store and the Ca2+ influx through voltage-dependent Ca2+ channels. 2. Marmin, skimmianine, aegeline, aurapten, zeorin, and dustanin are potential to develop as antihistamine agents, especially as histamine H1 receptor antagonists by interacting with amino acid residues, Asp107, Lys179, Lys191, Asn198, and Trp428 of histamine H1 receptor. 3. S-trans-Marmin shows potent antibacterial, fungicidal, and algicidal properties. 4. Marmin shows a cell-growth inhibitory effect against L1210 and K562 in vitro. 5. Marmin and nobiletin have anti-ulcer effects, which are ascribed primarily to the maintenance of the mucosal barrier integrity and inhibition of gastric motor activity and secondarily due to the prevention of the effects of endogenous acetylcholine and histamine. | |
| BCN1833 | Delaminomycin A |
| 1. Delaminomycin A is an immunomodulator. 2. Delaminomycin A is active against gram-positive bacteria. 3. Delaminomycin A is a cell adhesion inhibitor and extracellular matrix receptor antagonist. | |
| BCN1840 | Janolusimide |
| 1. Janolusimide is a neurotoxin and atropine antagonist. | |
| BCN2157 | Lobelin |
| 1. Inhalation challenge with capsaicin and rapid intravenous injection of Lobelin and alinamin indicated that peripheral c-fiber receptors were involved in the induction of coughing. | |
| BCN2228 | Kynurenic acid |
| Kynurenic acid, a natural metabolite of tryptophan via the kynurenine pathway, is a broad-spectrum excitatory amino acid antagonist; It proved to be an antagonist at NMDA, kainate and AMPA receptors.Kynurenic acid is the endogenous α7 nicotinic acetylcholine receptor antagonist, it has an immunomodulating effect, it can modulate amyloid-β-induced inflammation in BV-2 microglial cells. | |
