Products with Antagonists bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN5639 | Atropine |
| Atropine is a competitive antagonist of the muscarinic acetylcholine receptors (acetylcholine being the main neurotransmitter used by the parasympathetic nervous system), used to treat certain types of nerve agent and pesticide poisonings, some types of slow heart rate, and to decrease saliva production during surgery. | |
| BCN5672 | Wedelolactone |
| Wedelolactone is a potent Î2-arrestin-biased G protein-coupled receptor-35 (GPR35) agonist, GPR35 has been shown to be a target of the asthma drugs cromolyn disodium and nedocromil sodium. Wedelolactone has anti-inflammatory, growth inhibitory, anti-cancer, anti-fibrotic, and pro-apoptotic effects. Wedelolactone stimulates ER genomic and non-genomic signalling pathways; it can significantly inhibit the activation of LX-2 cells, the underlying mechanisms of which included inducing Bcl-2 family involved apoptosis, up-regulating phosphorylated status of ERK and JNK expressions, and inhibiting NF-κB mediated activity. | |
| BCN5807 | Caffeine |
| Caffeine has anxiolytic-like activity, can have both positive and negative effects on anxiety. It inhibits glucose transport by binding at the GLUT1 nucleotide-binding site. | |
| BCN5923 | Dendrobine |
| Dendrobine is an antagonist of β-alanine, taurine and of presynaptic inhibition in the frog spinal cord. Dendrobine has antiviral, and antitumor activities; it can inhibit the growth of A549 cells through inducing apoptosis, which is partially dependent on mitochondrial-mediated pathway; dendrobine treatment decreased mitochondrial membrane potential (MMP), improved the expression of Bax and inhibited the expression of Bcl-2. | |
| BCN6037 | Galanolactone |
| 1. Galanolactone shows cytotoxic activity . 2. Galanolactone has anti-5-HT effect, a diterpenoid isolated from ginger, is related to antagonism of 5-HT3 receptors. 3. Galanolactone exerts anti-obesity effect through down regulation of adipogenic transcription factors and adipogenic marker genes. 4. Galanolactone has inhibit nitric oxide production with IC(50) values ranging from 5.5 to 28.5 μM. | |
