(-)-VariabilinCAS# 370102-93-5 |
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 370102-93-5 | SDF | Download SDF |
| PubChem ID | 44428627 | Appearance | Powder |
| Formula | C17H16O5 | M.Wt | 300.3 |
| Type of Compound | Phenols | Storage | Desiccate at -20°C |
| Solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | ||
| Chemical Name | (6aS,11aS)-3,9-dimethoxy-6,11a-dihydro-[1]benzofuro[3,2-c]chromen-6a-ol | ||
| SMILES | COC1=CC2=C(C=C1)C3C(CO2)(C4=C(O3)C=C(C=C4)OC)O | ||
| Standard InChIKey | VVPGAJNPGZZNBM-DLBZAZTESA-N | ||
| Standard InChI | InChI=1S/C17H16O5/c1-19-10-3-5-12-14(7-10)21-9-17(18)13-6-4-11(20-2)8-15(13)22-16(12)17/h3-8,16,18H,9H2,1-2H3/t16-,17+/m0/s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
The roots of Angelica sinensis
| Description | 1. Variabilin, a novel inhibitor of human platelet aggregation, it is a potent RGD (Arg-Gly-Asp)-containing antagonist of the fibrinogen receptor glycoprotein IIb-IIIa (GPIIb-IIIa; αIIbβ3) and the vitronectin receptor αvβ3. 2. Variabilin is an inhibitor of human secretory and cytosolic phospholipase A2 (PLA2) activities that controls eicosanoid production in vitro and in vivo, inhibits neutrophil degranulation and superoxide generation in vitro and shows anti-inflammatory activity after topical or p.o. administration to mice. 3. Variabilin is an antimicrobial furanosesterterpene. 4. Variabilin is an important chemotaxonomic marker for the family Irciniidae. |
| Targets | Phospholipase (e.g. PLA) | Immunology & Inflammation related |
(-)-Variabilin Dilution Calculator
(-)-Variabilin Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.33 mL | 16.65 mL | 33.3 mL | 66.6001 mL | 83.2501 mL |
| 5 mM | 0.666 mL | 3.33 mL | 6.66 mL | 13.32 mL | 16.65 mL |
| 10 mM | 0.333 mL | 1.665 mL | 3.33 mL | 6.66 mL | 8.325 mL |
| 50 mM | 0.0666 mL | 0.333 mL | 0.666 mL | 1.332 mL | 1.665 mL |
| 100 mM | 0.0333 mL | 0.1665 mL | 0.333 mL | 0.666 mL | 0.8325 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
Featured Products
- Zinterol hydrochloride
Catalog No.:BCC6911
CAS No.:37000-20-7
- FCCP
Catalog No.:BCC5659
CAS No.:370-86-5
- TMPyP4 tosylate
Catalog No.:BCC7899
CAS No.:36951-72-1
- Oroxylin A 7-O-beta-D-glucuronide
Catalog No.:BCN2337
CAS No.:36948-76-2
- Icilin
Catalog No.:BCC4074
CAS No.:36945-98-9
- Hydramicromelin B
Catalog No.:BCN7560
CAS No.:369391-55-9
- 6-epi-Augustifolin
Catalog No.:BCN3233
CAS No.:369390-94-3
- Zebularine
Catalog No.:BCC1136
CAS No.:3690-10-6
- p-Coumaryl alcohol
Catalog No.:BCN3922
CAS No.:3690-05-9
- TC 14012
Catalog No.:BCC7910
CAS No.:368874-34-4
- Aucuparin
Catalog No.:BCN7450
CAS No.:3687-28-3
- Tramiprosate
Catalog No.:BCC7727
CAS No.:3687-18-1
New Products
- Carbetocin
Catalog No.:BCC6304
CAS No.:37025-55-1
- Cyclo(L-Phe-L-Pro)
Catalog No.:BCN4029
CAS No.:3705-26-8
- Cyclo(Gly-L-Pro)
Catalog No.:BCN4059
CAS No.:3705-27-9
- Z-Glu-OBzl
Catalog No.:BCC2780
CAS No.:3705-42-8
- Procyanidin C1
Catalog No.:BCN6317
CAS No.:37064-30-5
- Azlocillin sodium salt
Catalog No.:BCC4763
CAS No.:37091-65-9
- IC-87114
Catalog No.:BCC1161
CAS No.:371242-69-2
- Murrangatin
Catalog No.:BCN5426
CAS No.:37126-91-3
- 4'-Amino-3',5'-dichloroacetophenone
Catalog No.:BCC8678
CAS No.:37148-48-4
- Flavoxate hydrochloride
Catalog No.:BCC5208
CAS No.:3717-88-2
- PI-103
Catalog No.:BCC1162
CAS No.:371935-74-9
- PI-103 Hydrochloride
Catalog No.:BCC1860
CAS No.:371935-79-4
Larvicidal activity of isoflavonoids from Muellera frutescens extracts against Aedes aegypti.[Pubmed:23156998]
Nat Prod Commun. 2012 Oct;7(10):1319-22.
The biological activity of extracts from the leaves, bark and roots of Muellera frutescens, an Amazonian ichtyotoxic plant, were evaluated to find new environmentally safe insecticides. The n-hexane extracts of bark, leaf, and root showed a strong toxic activity against Aedes aegypti mosquito larvae. Bioguided fractionation of the bark extract led to the isolation of seven isoflavonoids (12a-hydroxyelliptone, elliptone, (-)-Variabilin, rotenone, rotenolone, tephrosin and deguelin). Rotenone and deguelin are responsible for the larvicidal activity of the plant. M frutescens leaves contain up to 0.6%, w/w, deguelin. These results justify the traditional ichtyotoxic use of M frutescens. The leaves contain a relatively high proportion of deguelin and, therefore, can be considered as a renewable source of this environmentally friendly insecticidal isoflavonoid.
Asymmetric total syntheses of (-)-variabilin and (-)-glycinol.[Pubmed:21667928]
Org Lett. 2011 Jul 15;13(14):3686-9.
Total syntheses of (-)-Variabilin and (-)-glycinol have been accomplished, using the catalytic, asymmetric "interrupted" Feist-Benary reaction (IFB) as the key transformation to introduce both stereogenic centers. A monoquinidine pyrimidinyl ether catalyst affords the IFB products in over 90% ee in both cases. Other key steps include an intramolecular Buchwald-Hartwig coupling and a nickel-catalyzed aryl tosylate reduction.
(-)-Variabilin,370102-93-5,Natural Products, buy (-)-Variabilin , (-)-Variabilin supplier , purchase (-)-Variabilin , (-)-Variabilin cost , (-)-Variabilin manufacturer , order (-)-Variabilin , high purity (-)-Variabilin
