Products with Anti-proliferation bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN3163 | Salvicine |
| 1. Salvicine inactivates β1 integrin and inhibits integrin-mediated cell adhesion to fibronectin. 2. Specificity of Salvicine and diversity of anticancer agents in the mechanism of interference with telomerase and the telomere system. 3. Salvicine has potent anti-angiogenic activity through the inhibition on the sequential angiogenic cascades: proliferation, migration and tube formation and is associated with influence on the expression of bFGF of tumor cell. 4. Salvicine has antimetastatic activity and shed new light on the complex roles of ROS and downstream signaling molecules, particularly p38 MAPK, in the regulation of integrin function and cell adhesion. | |
| BCN3183 | Platycodigenin |
| 1. Platycodigenin has in vitro anti-proliferative activity against the HSC-T6 cell line. | |
| BCN3234 | Effusanin E |
| 1. Effusanin E shows antibacterial activity. 2. Effusanin E significantly inhibits cell proliferation and induces apoptosis in NPC cells by suppressing p50/p65 proteins to down-regulate COX-2 expression . | |
| BCN3241 | Platycoside A |
| 1. Platycoside A induces the IgG and IgG1 antibody responses in the immunized mice. 2. Platycoside A has hemolytic activity and adjuvant potential on the immune responses to Newcastle disease virus-based recombinant avian influenza vaccine. | |
| BCN3261 | Chebulanin |
| 1. Chebulanin is a topoisomerase I inhibitor. 2. Chebulanin inhibits the calcineurin pathway in C. neoformans. 3. Chebulanin exhibits potent antifungal activity against various human pathogenic fungi with minimum inhibitory concentrations ranging from 0.25 to over 64 μg/ml. 4. Chebulanin suppresses the expression of inflammatory mediators and prevents cartilage destruction and bone erosion in mice, therefore, chebulanin is a strong therapeutic alternative for the treatment of rheumatism arthritis. 5. Chebulanin shows strong radical scavenging activity, good potency to chelate Fe2⁺ and good inhibition ability of lipid peroxidation. 6. Chebulanin has apparent capacities of inhibiting the survival of MCF-7 human cancer cell line. | |
