Products with Anti-proliferation bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN4136 | Acteoside |
| Acteoside is a lipase inhibitor, has neuroprotective, anti-obesity,anti-inflammatory, antioxidant, anticancer, cytotoxic,antihypertensive, analgesic, and antimetastatic activities. Acteoside can promote nerve growth factor and tropomycin receptor kinase A expression, inhibit arachidonic acid release and prostaglandin E2 production induced by 0.5 microM melittin. Acteoside can protect the cells from X‑ray induced damage through enhancing the scavenging activity of ROS, decreasing the Bax/Bcl-2 ratio and downregulating the activity of procaspase-3, as well as modulating the mitogen‑activated protein kinase signaling pathways. | |
| BCN4206 | Cirsimaritin |
| 1. Cirsimaritin has antibacterial, anti- inflammation, anti-tumor, antioxidant, renal protection and so on. 2. Cirsimaritin has potential use in patients with congestive heart failure, it can mitigate cardiac remodeling and left ventricular dysfunction through augmenting myocardial autophagy and decreasing matrix metalloproteinase-2&9 activities. 3. Cirsimaritin inhibits the growth of tumor cells and induced mitochondrial apoptosis in human gallbladder carcinoma cell line (GBC-SD), it triggers endoplasmic reticulum (ER) stress and down-regulates the phosphorylation of Akt. 4. Cirsimaritin increases tyrosinase activity and melanin content in murine B16F10 melanoma cells by activation of CREB as well as upregulation of MITF and tyrosinase expression in a dose-dependent manner;support the putative application of cirsimaritin in ultraviolet photoprotection and hair coloration treatments. 5. Cirsimaritin shows moderate anti-proliferative activity against COLO-205 cells with IC 50 values of 13.1uM. | |
| BCN4208 | Glochidiol |
| 1. Glochidiol exhibits strong inhibitory effects against all three human tumor cell lines (MCF-7, NCI-H-460 and SF-268), it exerts its antiproliferative activity through the involvement of apoptosis. 2. Glochidiol (IC50 = 290 mol ratio/32 pmol TPA) shows inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol 13-acetate (TPA). 3. Glochidiol exhibits a strong inhibitory effect on mouse skin tumor promotion in an in vivo mouse two-stage carcinogenesis test. | |
| BCN4227 | Spathulenol |
| 1. Spathulenol has immunomodulatory effect. 2. Spathulenol shows the capacity to inhibit proliferation in the lymphocytes and to induce apoptosis in these cells possibly through a caspase-3 independent pathway. 3. Spathulenol presents moderate or low cytotoxicity with IC50 higher than 6uM, it is a good candidate to be used in combination chemotherapy of MDR cancer and therefore is worthy for further in vivo studies. | |
| BCN4239 | Chonglou Saponin VII |
| 1. Chonglou saponin VII shows inhibitory effects on cell proliferation. | |
