Products with Anti-proliferation bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN4980 | Isorhynchophyllic acid |
| 1. Isorhynchophyllic acid can significantly inhibit the proliferation of human cancer cells(A549, HepG2 and A2780 cells) with IC50 values being 5.8, 12.8 and 11.8 umol/L, respectively. | |
| BCN4991 | Praeruptorin C |
| Praeruptorin C has been widely used as an antioxidant and a calcium antagonist to treat diseases, it partially protects cortical neurons by inhibiting the expression of GluN2B-containing NMDA receptors and regulating the Bcl-2 family. It has cardioprotective effect , it can reduce vascular hypertrophy in isolated rat hypertrophied smooth muscle cells, is important in prevention and treatment of vascular hyperplastic disease. | |
| BCN4994 | Typhaneoside |
| Typhaneoside is possibly the main active component in the bioactive fraction of Shaofu Zhuyu decoction, Shaofu Zhuyu decoction may have direct inhibitory effects on the contractility of the mice uterus. It has an inhibitory effect on the proliferation of human umbilical arterial smooth muscle cells(HUASMC) with a wide range of effective dose but the effect is started slowly. | |
| BCN5004 | Ophiopogonin D |
| 1. Ophiopogonin D plays a protective role as an effective antioxidant in H2O2-induced endothelial injury, it can be therefore developed as a novel drug for the therapy of cardiovascular disorders. 2. Ophiopogonin D can attenuate doxorubicin-induced autophagic cell death by relieving mitochondrial damage in vitro and in vivo. 3. Ophiopogonin D and spicatoside A can increase mucin production and secretion, by directly acting on airway epithelial cells, they could be as expectorants in diverse inflammatory pulmonary diseases. 4. Ophiopogonin D inhibits MCF-7 cell growth via the induction of cell cycle arrest at the G2/M phase. | |
| BCN5021 | Loureirin B |
| Loureirin B, a flavonoid extracted from Dracaena cochinchinensis, is an inhibitor of plasminogen activator inhibitor-1 (PAI-1), with an IC50 of 26.10 μM; Loureirin B also inhibits KATP, the phosphorylation of ERK and JNK, and has anti-diabetic activity.Loureirin B inhibits fibroblast proliferation and extracellular matrix deposition in hypertrophic scar via TGF-β/Smad pathway, loureirin B can suppress tetrodotoxin-sensitive (TTX-S) voltage-gated sodium currents in a dose-dependent way. | |
