Products with Anti-proliferation bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN5077 | Desmethoxycentaureidin |
| 1. Desmethoxycentaureidin shows high inhibitory activity against HeLa cell growth (GI50 9 microM). | |
| BCN5088 | Vomifoliol |
| 1. Vomifoliol is most likely the immediate precursor of dehydrovomifoliol, because of the organism converted abscisic acid (ABA), to dehydrovomifoliol as the major metabolise, and a cell-free extract exhibits vomifoliol dehydrogenase activity. 2. Vomifoliol and stigmasterol have anti-proliferative activity on human lung cancer cell lines. | |
| BCN5091 | Glochidonol |
| 1. Glochidonol exhibits strong inhibitory effects against three human tumor cell lines, MCF-7, NCI-H-460 and SF-268, the GI(50) values of 9.0 +/- 3.7, 4.9 +/- 0.2 and 9.8 +/- 0.5, respectively; it also exerts its antiproliferative activity through the involvement of apoptosis. | |
| BCN5234 | Heraclenol |
| 1. Heraclenol is a germination inhibitor in the parsley seeds. 2. Heraclenol has anti-inflammatory properties against the ear edema in mice produced by TPA. 3. Heraclenol and heraclenin inhibit the proliferation of melanoma cells and cell cycle at G2/M at concentrations of 0.1-1.0 uM. | |
| BCN5256 | Gartanin |
| 1. Gartanin possesses potent antioxidant, anti-inflammatory, antifungal and antineoplastic properties. 2. Gartanin induces protective autophagy mainly by JNK-Bcl-2 pathway. 3. Gartanin is an androgen receptor degradation enhancer. 4. Gartanin is a potential neuroprotective agent against glutamate-induced oxidative injury partially through increasing Nrf-2-independed HO-1 and AMPK/SIRT1/PGC-1αsignaling pathways. 5. Gartanin has anti-proliferation effect in T98G cells, which is most likely via cell cycle arrest modulated by autophagy, which is regulated by PI3K/Akt/mTOR signalling pathway, while its anti-migration effect is most likely via suppression of MMP-2/-9 activity which is involved in MAPK signalling pathway. | |
