Products with Anti-proliferation bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN5544 | Atranorin |
| 1. Atranorin shows significant antinociceptive and antiinflammatory activity. 2. Atranorin has a relevant redox-active action, acting as a pro-oxidant or antioxidant agent depending on the radical, also, it will exert cytoprotective effects on cells under oxidative stress induced by H(2)O(2). 3. Atranorin has suppression of viability and proliferation in tumour cell lines. | |
| BCN5551 | Isorhamnetin |
| Isorhamnetin, a natural flavonol aglycon, is a tyrosinase inhibitor and has anti-adipogenic, cardioprotective, anti-tumor, and antioxidant activities. it inhibits the H(2)O(2)-induced activation of the intrinsic apoptotic pathway via ROS scavenging and ERK inactivation, it inhibits NF-κB signaling. Isorhamnetin prevents angiotensin II (AngII)-induced endothelial dysfunction by inhibiting the overexpression of p47(phox) and the subsequent increases O2-production, resulting in increased nitric oxide bioavailability. | |
| BCN5579 | Sphondin |
| 1. Sphondin possesses an inhibitory effect on IL-1beta-induced increase in the level of COX-2 protein and PGE(2) release in A549 cells through suppression of NF-kappaB activity, it may have the therapeutic potential as an anti-inflammatory drug on airway inflammation. 2. Sphondin, 8-methoxypsoralen, and khellin have delayed phototoxic effects inAedes aegypti. 3. Sphondin has NO production inhibitory activity, due to the effect of iNOS expression, it may act as a potent inhibitor of NO production under tissue-damaging inflammatory conditions. 4. Sphondin may have anticonvulsant activity. 5. Sphondin shows anti-proliferative activity and causes G2/M arrest at concentrations of 0.05-15.0 uM, it may have anti-tumor effects. | |
| BCN5589 | Vasicinone |
| 1. Vasicinone may act as a hepatoprotective agent. 2. (±)-Vasicinone has significant antitussive, expectorant, and bronchodilating activities, which can be used to treat respiratory disease. 3. (S)-Vasicinone exhibits antiproliferative activity against human gastric cancer cells MCG-803. | |
| BCN5681 | Tryptophol |
| Tryptophol is an aromatic alcohol found as a secondary product of alcoholic fermentation that induces sleep in humans. Tryptophol can inhibit the infection/replication of GVE2 by interacting with the host's Clp protease. Tryptophol can inhibit the proliferation of U937 cells by inducing apoptosis via a pathway involving caspase-8 followed by caspase-3. Tryptophol induces apoptosis through Death Receptor (DR) 5 and that the resistance of peripheral blood lymphocytes (PBL) to tryptophol-induced apoptosis might be due to competition from decoy receptor (DcR). | |
