Products with Anti-proliferation bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN4269 | 17alpha-Neriifolin |
| 1. 17alpha-Neriifolin and 17alpha-Deacetyltanghinin have little anti-proliferative activity, indicating that the 17beta configuration is critical for the anti-proliferative activity of these compounds. | |
| BCN4333 | 9-Oxo-10,11-dehydroageraphorone |
| 1. 9-Oxo-10,11-dehydroageraphorone has acaricidal activity. 2. 9-Oxo-10,11-dehydroageraphorone induces hepatotoxicity and cholestasis in rats. 3. 9-Oxo-10,11-dehydroageraphorone effectively inhibits the proliferation of HeLa cells by arresting the cell cycle transition from S to G2/M phase. | |
| BCN4373 | Ethyl gallate |
| Ethyl gallate has anti-cancer, antioxidant activities, it may be an alternative class of vasopressors for use in septic shock. Ethyl gallate can treat acute lung injury (ALI) mainly by reducing the total cells and infiltration of activated polymorphonuclear leukocytes (PMNs). Ethyl gallate inhibits Akt , NF-κB p-65, Bcl-2/Bax, and mRNA levels of MMP-2 and MMP-9. | |
| BCN4387 | Rocaglamide |
| 1. Rocaglamide induces apoptosis through the intrinsic death pathway in various human leukemia cell lines and in acute lymphoblastic leukemia, chronic myeloid leukemia and acute myeloid leukemia cells freshly isolated from patients. 2. Rocaglamides are potent natural anticancer products that inhibit proliferation of various cancer cells at nanomolar concentrations, it prevents tumor growth and sensitize resistant cancer cells to apoptosis by blocking the MEK-ERK-eIF4 pathway. 3. Rocaglamides can suppress the PMA-induced expression of NF-kappaB target genes and sensitize leukemic T cells to apoptosis induced by TNFalpha, cisplatin, and gamma-irradiation, suggests that rocaglamide derivatives could serve as lead structures in the development of anti-inflammatory and tumoricidal drugs. 4. Rocaglamide and a XIAP inhibitor cooperatively sensitize TRAIL-mediated apoptosis in Hodgkin's lymphomas. | |
| BCN4405 | Eupatorin |
| Eupatorin has antiproliferative and antiangiogenic effects, it emerges as a promising agent in anticancer research.Eupatorin-induced cell death is mediated by both the extrinsic and the intrinsic apoptotic pathways and through a mechanism dependent on reactive oxygen species generation. Eupatorin also has meaningful anti-inflammatory property which may be utilized in the development of novel anti-inflammatory treatments. | |
