Products with Anti-proliferation bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN3825 | 2,5-Dihydroxyacetophenone |
| 2,5-Dihydroxyacetophenone is an uncompetitive inhibitor of murine tyrosinase (K(I) 0.28mm), it strongly inhibits both melanogenesis and cellular tyrosinase activity, it possesses anti-inflammatoryanti-anxiety, and neuroprotective qualities. 2,5-Dihydroxyacetophenone treatment can induce a sustained activation of JNK, ERK1/2, and p38 MAPKs, it also can potentiate the pro-apoptotic and anti-proliferative effects of bortezomib in U266 cells. | |
| BCN3833 | Panaxynol |
| Panaxynol is the most potent antiplatelet agent in ginseng and its mechanism of action is chiefly due to the inhibition of thromboxane formation. Panaxynol has neuroprotective, and anti-proliferative effects, it induces neurite outgrowth in PC12D cells via cAMP- and MAP kinase-dependent mechanisms, and protects cortical neurons from ischemia-like injury by up-regulation of HIF-1alpha expression and inhibition of apoptotic cascade. Panaxynol has inhibitory effects on the proliferation of human pancreatic cancer cell PANC-1through inhibiting cell division and down-regulating Ki67 expression. | |
| BCN3847 | Platycodin D2 |
| 1. Platycodin D2 , a less hemolytic saponin, can improve specific cellular and humoral responses to hepatitis B surface antigen in mice. 2. Platycodin D2 could be safely used as adjuvant eliciting Th1 and Th2 immune responses. 3. Polygalacin D2 exhibits significant inhibition on the proliferation of five kinds of cultured human tumor cell lines, i. e., A549 (non-small cell lung), SK-OV-3 (ovary), SK-MEL-2 (melanoma), XF498 (central nerve system) and HCT-15 (colon), in vitro. | |
| BCN3880 | alpha-Carotene |
| 1. alpha-Carotene has a stronger effect than beta-carotene in suppressing the promoting activity of 12-O-tetradecanoylphorbol-13-acetate on skin carcinogenesis in 7,12-dimethylbenz[a]anthracene-initiated mice. 2. alpha-Carotene has inhibitory effects on proliferation of the human neuroblastoma cell line GOTO. 3. alpha-Carotene inhibits metastasis in Lewis lung carcinoma in vitro, and suppresses lung metastasis and tumor growth in combination with taxol in tumor xenografted C57BL/6 mice. | |
| BCN4040 | Nagilactone C |
| 1. Nagilactone C possesses potent antiproliferative activity against human fibrosarcoma and murine colon carcinoma tumor cell lines exhibiting ED50 values of 2.3 and 1.2 microg/ml, respectively. 2. Nagilactone C and phyllanthoside are novel protein synthesis inhibitors, they are specific for the eukaryotic translation apparatus, function in vivo and in vitro, and interfere with translation elongation. 3. Nagilactone C shows high insecticidal activity against second-instar nymphs of Eocanthecona furcellata. | |
