Products with Inhibitors bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN5742 | Mollugin |
| Mollugin is a JAK2 inhibitor and inhibits LPS-induced inflammatory responses by blocking the activation of the JAK-STAT pathway. Mollugin may be a novel therapeutic candidate for bone loss-associated disorders including osteoporosis, rheumatoid arthritis, and periodontitis. Mollugin has anticancer efficacy, can modulate the HER2, HO-1, Nrf2 , and NF- κB pathways. | |
| BCN5747 | Friedelin |
| Friedelin possesses antioxidant, gastroprotective, anti-diarrhoeal, liver protective, anti-inflammatory, analgesic and antipyretic activities.Friedelin rich fraction (IND-HE) shows estrogenic activity as indicated by vaginal cornification, increase in uterine weight and rise in serum estrogen. Friedelin may be beneficial to mimic insulin action that would be useful in the treatment of diabetes type 2 patients. | |
| BCN5751 | 3-(2,4-Dihydroxyphenyl)propionic acid |
| 3-(2,4-Dihydroxyphenyl)propionic acid and l-ascorbic acid show tyrosinase inhibition activity, a synergistic effect on tyrosinase inhibition was observed when the two compounds were mixed. | |
| BCN5760 | Steppogenin |
| 1. Steppogenin exhibits significant tyrosinase inhibition activities. 2. Steppogenin shows strong mushroom tyrosinase inhibitory activity with IC(50) values lower than 50 microM, more potent than kojic acid (IC(50) = 71.6 microM), a well-known tyrosinase inhibitor. | |
| BCN5767 | Penduletin |
| 1. Penduletin shows anti- tumor cells activity. 2. Penduletin significantly reduces TGF-β1 production. 3. Penduletin has strong activity in vitro against EV71 with low cytotoxicity. 4. Penduletin inhibits growth of the Gram-negative pathogen neisseria gonorrhoeae. 5. Penduletin may have anti-inflammatory activity, it can partially inhibit synovial phospholipase A2 activity. | |
