Products with Inhibitors bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN5621 | Rosenonolactone |
| 1. Rosenonolactone shows inhibitory activity against prolyl endopeptidase and thrombin. | |
| BCN5655 | Tectochrysin |
| Tectochrysin is a promising inhibitor for the reversal of ABCG2-mediated drug transport, it leads to apoptotic cell death in NSCLC cells through activation of DR3 and Fas expression via inhibition of STAT3 phosphorylation.Tectochrysin has antioxidant effect, it also exhibits a significant hepatoprotective activity in hepatic damage induced by CCl4-intoxication in rats. | |
| BCN5656 | Tricin |
| 1. Tricin is evaluated as a type of tyrosinase inhibitor. 2. Tricin derivatives conveys allergy and inflammation treatment ability to Z. latifolia. 3. Tricin exerts anti-inflammatory effect via a mechanism involving the TLR4/NF-κB/STAT signaling cascade. 4. Tricin may be beneficial in HSC-targeting therapeutic or chemopreventive applications for hepatic fibrosis. 5. Tricin is a novel compound with potential anti-HCMV activity and that CXCL11 is one of the chemokines involved in HCMV replication. | |
| BCN5664 | Evoxine |
| 1. Evoxine is a small molecule that counteracts CO2-Induced immune suppression, it can counteract the CO2-induced transcriptional suppression of antimicrobial peptides in S2* cells. 2. Evoxine and arborinine display moderate antiplasmodial activity against the CQS D10 strain of Plasmodium falciparum, with IC(50) values of 24.5 and 12.3 microM, respectively. | |
| BCN5672 | Wedelolactone |
| Wedelolactone is a potent Î2-arrestin-biased G protein-coupled receptor-35 (GPR35) agonist, GPR35 has been shown to be a target of the asthma drugs cromolyn disodium and nedocromil sodium. Wedelolactone has anti-inflammatory, growth inhibitory, anti-cancer, anti-fibrotic, and pro-apoptotic effects. Wedelolactone stimulates ER genomic and non-genomic signalling pathways; it can significantly inhibit the activation of LX-2 cells, the underlying mechanisms of which included inducing Bcl-2 family involved apoptosis, up-regulating phosphorylated status of ERK and JNK expressions, and inhibiting NF-κB mediated activity. | |
