Products with Inhibitors bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN5571 | Tetrahydroamentoflavone |
| 1. (2S,2″S )-Tetrahydroamentoflavone exerts its antioxidant activity in vitro through metal-chelating, and radical-scavenging, which is via donating a hydrogen atom (H61) and an electron (e). 2. Tetrahydroamentoflavone is a potent XO inhibitor, may be considered as a drug candidate or chemopreventive agent. 3. Tetrahydroamentoflavone has anti-inflammatory effects, it shows in vitro cyclooxygenase (COX) inhibition activity ( an IC(50) value of 29.5 microM (COX-1) and 40.5% inhibition at 100 microg/mL (COX-2)). | |
| BCN5588 | Bergaptol |
| Bergaptol acts as a potent inhibitor of debenzylation activity of CYP3A4 enzyme with an IC50 value of 24.92 uM.Bergaptol shows very good radical scavenging activity, it induces dose-dependent cytotoxic effect on MCF-7 cell viability. | |
| BCN5592 | Butein |
| Butein is a chelator of ferrous and copper ions, is able to inhibit the activation of protein tyrosine kinase, NF-κB and STAT3, also inhibits EGFR. Butein can inactivate PMA-activated AP-1, due to the blocking of JNK-mediated c-Jun phosphorylation through the inhibition of ATP binding. Butein has potent anticancer, anti-inflammatory, antioxidant activities, it also has a hypotensive effect, at least in part, via the inhibition of angiotensin converting enzyme. | |
| BCN5594 | vibo-Quercitol |
| (-)-vibo-Quercitol is a carbaglycosylamine glycosidase inhibitor. | |
| BCN5596 | Robinetin |
| 1. Robinetin has antioxidant and antiradical activities, inhibits EYPC membrane lipid peroxidation and HbA glycosylation with high efficiency. 2. Robinetin leads to the occurrence of positive induced circular dichroism (ICD) bands in the near ultra-violet (UV) region. 3. Robinetin has anti-mutagenesis and anti-promotion effects, diminishes ornithine decarboxylase activity induction at 6 h after 12-O-tetradecanoyl phorbol-13-acetate. | |
