Products with Inhibitors bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN5463 | Lipiferolide |
| 1. Lipiferolide is an inhibitor of farnesyl protein transferase(FPTase), it inhibits the FPTase activity in a dose-dependent manner, and shows cell growth inhibitory activity against several tumor cells. 2. Liriodenine has antiplasmodial activity. 3. Lipiferolide and epitulipinolide diepoxide possess cytotoxic activity against KB cells. | |
| BCN5477 | Acuminatin |
| 1. (+)-trans-Acuminatin, and (+)-cis-acuminatin show weak activity against platelet aggregation with IC50 values of 108.5 and 90.02 uM, respectively. 2. (-)-Acuminatin, and machilin G show dose-dependent potent inhibitory activities against PLCgamma1 in vitro with IC50 values ranging from 8.8 to 26.0 microM, the inhibition of PLCgamma1 may be an important mechanism for an antiproliferative effect on the human cancer cells, therefore, these inhibitors may be utilized as cancer chemotherapeutic and chemopreventive agents. 3. (-)-Acuminatin exerts hepatoprotective activities, perhaps by serving as a potent antioxidant. | |
| BCN5498 | 2,4,5-Trimethoxybenzaldehyde |
| 2,4,5-Trimethoxybenzaldehyde (2,4,5-TMBA) has anti-adipogenic potential, is a natural cyclooxygenase II (COX-2) inhibitor, suppresses the differentiation of preadipocyts into adipocytes at the concentration of 0.5 mM. | |
| BCN5499 | Genistein |
| Genistein, a phytoestrogen found in soy products, is a highly specific inhibitor of protein tyrosine kinase (PTK) which blocks the mitogenic effect mediated by EGF on NIH-3T3 cells with IC50 of 12μM or by insulin with IC50 of 19 μM. Genistein has neuroprotective, antitumor effects, it modulates the expression of NF-κB and MAPK (p-38 and ERK1/2), thereby attenuating d-Galactosamine induced fulminant hepatic failure in Wistar rats. | |
| BCN5514 | Hederagonic acid |
| 1. Hederagonic acid ,arjunolic acid, bayogenin, and 4-epi-hederagonic acid show moderate potency of glycogen phosphorylase inhibition with IC50 of 53-103 uM. | |
