Products with Inhibitors bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN5230 | Isotachioside |
| 1. Isotachioside has15-lipoxygenase (15-LO) inhibitory activities. | |
| BCN5236 | Pinusolide |
| 1. Pinusolide is a platelet activating factor ( PAF) antagonist, it may prove of therapeutic value in the treatment of hypotension . 2. Pinusolide has antileukemic potential, it not only decreases the proliferation activity of tumor cells at relatively low concentrations but specifically induces apoptosis at 100 microM via the mitochondrial pathway in the Burkitt lymphoma cell line BJAB. 3. Pinusolide attenuates blockade of insulin signaling by enhancing IRS-1 tyrosine phosphorylation by the activating the AMPK pathway, indicates the targeting of AMPK represents a new therapeutic strategy for hyperglycemia-induced insulin resistance and type 2 diabetes. 4. Pinusolide can protect neuronal cells from staurosporine (STS) -induced apoptosis, probably by preventing the increase in [Ca2+]i and cellular oxidation caused by STS, and indicate that it could be used to treat neurodegenerative diseases. 5. Pinusolide shows potent inhibition of 5-LO dependent LTC4 generation, which requires both suppression of calcium influx and JNK phosphorylation. | |
| BCN5238 | Methyl orsellinate |
| 1. Methyl orsellinate is a phytotoxic compound, it can cause significant inhibition of radicle growth of Amaranthus hypochondriacus and Echinochloa crus-galli, interact with bovine-brain calmodulin and inhibit the activation of the calmodulin-dependent enzyme cAMP phosphodiesterase. 2. Methyl orsellinate exhibits antifungal activity. 3. Methyl orsellinate can inhibit PTP1B activity with 50% inhibitory concentration values of 277 +/- 8.6 microM, the selective inhibition of PTP1B has been widely recognized as a potential drug target for the treatment of type 2 diabetes and obesity, methyl orsellinate may can treat the type 2 diabetes and obesity. | |
| BCN5239 | Ethyl glucoside |
| 1. Ethyl glucoside is a shale inhibitor for water base drilling fluids. 2. Ethyl glucoside is a multifunctional initiator for enzyme-catalyzed regioselective lactone ring-opening polymerization. | |
| BCN5243 | Myricanone |
| 1. Myricanone has anticancer activity. 2. Myricanone has apoptosis-promoting ability by triggering caspase activation, and suppression of cell proliferation by down-regulation of NF-κB and STAT3 signalling cascades. 3. Myricanone displays significant antioxidant activity. 4. Myricanone shows in vitro testosterone 5alpha-reductase inhibitory activity and in vivo anti-androgenic activity using growth of flank organ in castrated Syrian hamsters and/or hair regrowth after shaving in testosterone-treated C57Black/6CrSlc mice. | |
