Products with Inhibitors bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN5426 | Murrangatin |
| 1. Murrangatin and murracarpin show chondroprotective activity by downregulation of interleukin-1β, tumor necrosis factorα, prostaglandins E2,and matrix metalloproteinases -13, and both of them may be a new backbone for developing inhibitors of cyclooxygenase 2. 2. Murrangatin can significantly inhibit Epstein–Barr virus early antigen (EBV–EA) activation, and preserve the high viability of Raji cells, suggests that it may be a valuable anti-tumor-promoting agent. 3. Murrangatin exhibits cytotoxicity against cholangiocarcinoma cell line, KKU-100. 4. Murrangatin exhibits antibacterial activity against P. gingivalis (ATCC 33277). 5. Murrangatin shows soluble epoxide hydrolase inhibitory activity with IC50 values 13.9±6.5uM. | |
| BCN5433 | Cimifugin |
| Cimifugin evidently inhibits FITC-induced type 2 allergic contact dermatitis,and its mechanism might related to regulating the balance of Th1 /Th2 by inhibiting type 2 cytokines. Cimifugin displayed low to moderate inhibition towards AChE and BChE (3.12 and 21.63%, respectively) at 200 ug/mL. | |
| BCN5442 | 2'-O-Methylperlatolic acid |
| 1. 2'-O-Methylperlatolic acid and confluentic acid are monoamine oxidase B inhibitors in a Brazilian plant, Himatanthus sucuuba. | |
| BCN5444 | Nuezhenide |
| Nuezhenide is the main inhibitory compound of fruits, it shows a clear inhibitory effect to the seeds of wheat and Chinese cabbage. It significantly protects human neuroblastoma SH-SY5Y cells from 6-hydroxydopamine-induced neurotoxicity. | |
| BCN5452 | Methyllinderone |
| 1. Methyllinderone has antioxidant property. 2. Methyllinderone is a human chymase inhibitor. 3. Methyllinderone shows moderate to weak antifungal activities against various pathogenic fungi. 4. Methyllinderone can inhibit farnesyl protein transferase with IC50 value of 55.3+/-4.1microM and selectively inhibit the growth of H-ras-transformed rat-2 cell lines with a GI50 value of 0.3 microM. 5. Methyllinderone shows significant cytotoxicity against mouse melanoma (B16-F10), human acetabulum fibrosarcoma (HT1080), and choronic myelogenous leukemia (K562) cancer cell lines with ED(50) values of 2.2, 2.5, 8.3 mug/ml, respectively. | |
