Products with Inhibitors bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN5539 | Damnacanthal |
| 1. Damnacanthal possesses anti-cancer property, can treat or prevent hepatocellular carcinoma through its inhibitory effects on the HGF/c-Met axis. 2. Damnacanthal inhibits mast cell activation induced by different stimuli and open a new window for the use of this compound as a mast cell stabilizer. 3. P53-mediated Damnacanthal induces apoptosis through the activation of p21 and caspase-7. 4. Damnacanthal possesses anti-inflammatory property, can inhibit the NF-κB/receptor-interacting protein-2/caspase-1 signal pathway by inhibiting p56lck tyrosine kinase . 5. Damnacanthal and noni extract supplements containing it could be potentially interesting for the treatment and/or chemoprevention of hepatocellular carcinoma through its inhibitory effects on the HGF/c-Met axis. 6. Damnacanthal has antinociceptive and anti-inflammatory actions in mice. 7. Damnacanthal can act as an immunomodulatory agent which may be very useful for maintaining a healthy immune system. | |
| BCN5543 | Berbamine |
| Berbamine is a novel inhibitor of bcr/abl fusion gene with potent anti-leukemia activity and also an inhibitor of NF-κB. Berbamine may be the first ATP-competitive inhibitor of CaMKII γ, could be as a new type of molecular targeted agent through inhibition of the CaMKII γ activity for treatment of leukemia.Berbamine confers cardioprotection against I/R injury by attenuating [Ca(2+)inf(i) overloading and preventing calpain activation through the activation of the PI3K-Akt-GSK3β pathway and, subsequently, opening of the mitoK(ATP) channel. | |
| BCN5553 | Orobol |
| 1. Isoflavonoid compounds, orobol, psi-tectorigenin and genistein have been implicated as inhibitors of tyrosine-specific protein kinase and phosphatidylinositol turnover. 2. Orobol has sensitization effect, it can produce produced cisplatin (DDP) sensitivity in human ovarian carcinoma cells by inducing apoptosis through the MT-dependent signaling pathway. 3. Orobol and platelet derived growth factor (PDGF) regulate paclitaxel (PX) sensitivity by reciprocally altering the proportion of tubulin isotype expression and PX-induced apoptotic signaling. 4. Orobol exhibits antiviral effects against some animal viruses, addition of the compound after virus entry inhibits the appearance of late viral protein synthesis in Vesicular Stomatitis Virus, influenza, or vaccinia virus-infected cells, but has no effect on poliovirus protein synthesis. | |
| BCN5562 | Lecanoric acid |
| 1. Lecanoric acid analogues antagonizes several enzymic and cellular effects of the tumour promoter. 2. Lecanoric acid analogues inhibits prostaglandin synthetase and delayed-type hypersensitivity responses against sheep red blood cells in mice. 3. Lecanoric acid shows antioxidant activity with an IC50 value of 79-95 ug/ml, it at 100 ug/ml conc. shows high growth stimulating activity in terms of increased dry matter of biomass (56.08 mg) of L. casei. | |
| BCN5568 | Isopimpinellin |
| Isopimpinellin has chemopreventive effects, it effectively inhibits mouse COH activity (IC50 values 19-40 microM).Isopimpinellin is a new inhibitor against the Leishmania APRT enzyme. | |
