Products with Inhibitors bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN5294 | Norathyriol |
| 1. Norathyriol is a potent PTP1B inhibitor with good cell permeability and oral availability. 2. Norathyriol can improve the glucose utilization and insulin sensitivity by up-regulation of the phosphorylation of AMPK. 3. Norathyriol exerts a potent chemopreventive activity by inhibiting Akt activation in neoplastic cell transformation. 4. Norathyriol as a safe new chemopreventive agent that is highly effective against development of UV-induced skin cancer. 5. Norathyriol may be a dual, yet weak, cyclooxygenase and lipoxygenase pathway blocker, it has anti-inflammatory effect, and has inhibitory effect on the A23187-induced pleurisy and acetic acid-induced writhing response in mice. 6. Norathyriol can relax the rat thoracic aorta mainly by suppressing the Ca2+ influx through both voltage-dependent and receptor-operated calcium channels. | |
| BCN5313 | 3-Acetoxy-11-ursen-28,13-olide |
| 1. 3β-Acetoxy-urs-11-en-28,13-olide exhibits significant protein tyrosine phosphatase 1B (PTP1B) inhibitory activity, it is a mixed-type PTP1B inhibitor. 2. 3β-Acetoxy-urs-11-en-28,13β-olide exhibits weak-moderate antiproliferative activity against the A2780 human ovarian cancer cell line. | |
| BCN5320 | N-p-trans-Coumaroyltyramine |
| Paprazine may have cytotoxic activity. | |
| BCN5335 | Decursin |
| Decursin has antiepileptic, hepatoprotective, anti-cancer, anti-inflammatory, and anti-amnesic activities, it is a novel candidate for inhibition of VEGF-induced angiogenesis. Decursin inhibited the TGF-β1 induced NOX activation and Smad signaling, it inhibited the PKCα, MAPK and NF-κB pathways. Decursin is also a novel inhibitor of NF-kappaB activation in signaling induced by TLR ligands and cytokines. | |
| BCN5354 | Acetate gossypol |
| Acetate gossypol has antifertility action. Acetate gossypol is a potent inhibitor of Bcl-2 and Bcl-xl, it has significant antiproliferative and antiapoptotic effects on multiple myeloma cells in vitro and in vivo, it also has apoptosis-inducing activity in primary cultured leukemia cells. | |
