Products with Inhibitors bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN5108 | 5'-S-Methyl-5'-thioadenosine |
| 1. S-Methyl-5′-thioadenosine can inhibit the activity of ThiC (4-amino-5-hydroxymethyl-2- methylpyrimidine phosphate synthase). | |
| BCN5109 | 3-Geranyl-4-methoxybenzoic acid |
| 1. 3-Geranyl-4-methoxybenzoic acid exhibits stronger inhibition effect on the activation of hyaluronidase than that of tranilast. | |
| BCN5114 | (-)-Epiafzelechin |
| 1. (-)-Epiafzelechin exhibits a dose-dependent inhibition on the COX activity with an IC50 value of 15 microM, it exhibits about 3-fold weaker inhibitory potency on the enzyme activity than indomethacin as a positive control. 2. (-)-Epiafzelechin exhibits significant anti-inflammatory activity on carrageenin-induced mouse paw edema when the compound (100 mg/kg) was orally administrated at 1 h before carrageenin treatment. 3. (-)-Epicatechin shows zero and/or the lowest activities against pancreatic lipase (IC50 > 20 microM). 4. Epiafzelechin has antioxidant properties. | |
| BCN5121 | (+)-Afzelechin |
| 1. (+)-Afzelechin has a neuroprotective effect on the glutamate-induced neurotoxicity in HT22 cells, it has ABTS cation radical scavenging effects with IC50 values of 23.7 microM, suggests that it could be neuroprotectants owing to their free radical scavenging activities. 2. (+)-Afzelechin has inhibitory compound of alpha-glucosidase activity, the ID(50) (50% inhibition dose) value is 0.13 mM. 3. (+)-Afzelechin shows moderate to strong radical scavenging properties against diphenylpicrylhydrazyl radical (DPPH) and improves the reduced glutathione levels in rat pancreatic homogenate. | |
| BCN5122 | Isoferulic acid |
| Isoferulic acid is an effective natural antioxidant in both lipid and aqueous media, it may be a new promising anti-glycation agent for the prevention of diabetic complications via inhibition of advanced glycation end products (AGEs) formation and oxidation-dependent protein damage. Isoferulic acid is a novel and potent inhibitor of murine IL-8 production, it also has inhibitory effect on mushroom tyrosinase.3-Hydroxy-4-methoxycinnamic acid shows anti-inflammatory, antiviral, antioxidant, and antidiabetic properties, it is an anti-glycation agent, inhibits fructose- and glucose-mediated protein glycation. | |
