Products with Inhibitors bioactivity
| Cat.No. | Product Name |
|---|---|
| BCN5378 | Ophiopogonin B |
| 1. Ophiopogonin B is often used in Chinese traditional medicine to treat pulmonary disease, it is a prospective inhibitor of PI3K/Akt and may be used as an alternative compound to treat NSCLC. 2. Ophiopogonin B induces apoptosis, mitotic catastrophe and autophagy , has inhibitory effect on adhesion, invasion and migration of A549 cells in vitro. 3. Ophiopogonin B may be considered a potential inhibitor of gastric cancer progression, and may be used as an alternative compound for its treatment. | |
| BCN5383 | Atractyloside A |
| 1. Atractyloside is a toxic compound from wedelia glauca. 2. Atractyloside acts as inhibitor of oxidative phosphorylation by a specific interference with energy-transfer reactions, the effect of atractyloside is due to inhibition of the ADP utilizing process in the coupling system. 3. Atractyloside, has been proposed for the antibiotic oligomycin, is an inhibitor of the energy-transfer reactions in animal mitochondria; it inhibits the phosphate uptake and the respiratory stimulation induced by P1-acceptor, but it does not interfere with the so-called resting respiration. | |
| BCN5390 | Luteosporin |
| 1. Luteosporin and xanthomegnin are pigments, they are suspected to be genotoxic carcinogens. 2. Luteosporin inhibits porcine pancreatic phospholipase A2 (PLA2) with Ki values of 12.8 microM. | |
| BCN5401 | Arenobufagin |
| Arenobufagin is a potent Na + /K + pump inhibitor, and is also a specific inhibitor of VEGF-mediated angiogenesis. Arenobufagin has antineoplastic effect that involves cross talk between apoptosis and autophagy via inhibition of the PI3K/Akt/mTOR pathway. | |
| BCN5408 | Hecogenin |
| Hecogenin, a steroid saponin isolated from Agave sisalana, is a potent and highly selective inhibitor of UGT1A4 with an IC50 value of 1.5 μM. Hecogenin has anti-cancer, antiproliferative,antioxidant and anti-inflammatory effects, it can protect gastro by K⁺(ATP) channels opening and the COX-2/PG pathway. Hecogenin has inhibition of human rheumatoid arthritis synovial cell survival, the effect is associated with increased apoptosis, p38 mitogen-activated protein kinase activity and upregulation of cyclooxygenase-2. | |
